Publications by authors named "Ralph Gottschalk"

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Whole Exome Sequencing Is the Preferred Strategy to Identify the Genetic Defect in Patients With a Probable or Possible Mitochondrial Cause.
Tom E J Theunissen, Minh Nguyen, Rick Kamps, Alexandra T Hendrickx, Suzanne C E H Sallevelt, Ralph W H Gottschalk

Front Genet· October 2018

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Novel SLC25A32 mutation in a patient with a severe neuromuscular phenotype.
Debby M E I Hellebrekers, Suzanne C E H Sallevelt, Tom E J Theunissen, Alexandra T M Hendrickx, Ralph W Gottschalk

Eur J Hum Genet· June 2017

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Polyhydramnios and cerebellar atrophy: a prenatal presentation of mitochondrial encephalomyopathy caused by mutations in the FBXL4 gene.
Maartje C van Rij, Fenna A R Jansen, Debby M E I Hellebrekers, W Onkenhout, Hubert J M Smeets, Ralph W H Gottschalk

Clin Case Rep· April 2016

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Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival.
Frits H M van Osch, An M Voets, Leo J Schouten, Ralph W H Gottschalk, Colinda C J M Simons

Carcinogenesis· December 2015

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Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans.
Danyel G J Jennen, Danitsja M van Leeuwen, Diana M Hendrickx, Ralph W H Gottschalk, Joost H M van Delft

Chem Res Toxicol· October 2015

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Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.
Hans B Ketelslegers, Roger W L Godschalk, Ralph W H Gottschalk, Ad M Knaapen, Gudrun Koppen

Environ Health· October 2011

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Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer.
Brenda W C Bongaerts, Anton F P M de Goeij, Kim A D Wouters, Manon van Engeland, Ralph W H Gottschalk

Alcohol· May 2011

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Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
Stefan de Vogel, Kim A D Wouters, Ralph W H Gottschalk, Frederik J van Schooten, Anton F P M de Goeij

Cancer Causes Control· January 2011

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Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds.
Rob J Vandebriel, Jeroen L A Pennings, Kirsten A Baken, Tessa E Pronk, Andre Boorsma, Ralph Gottschalk

Toxicol Sci· September 2010

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Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells.
Jacob J Briedé, Joost M H van Delft, Theo M C M de Kok, Marcel H M van Herwijnen, Lou M Maas, Ralph W H Gottschalk

Toxicol Sci· April 2010

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Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.
Karen Mathijs, Karen J J Brauers, Danyel G J Jennen, Andre Boorsma, Marcel H M van Herwijnen, Ralph W H Gottschalk

Toxicol Sci· December 2009

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Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.
Stefan de Vogel, Kim A D Wouters, Ralph W H Gottschalk, Frederik J van Schooten, Anton F P M de Goeij

Cancer Epidemiol Biomarkers Prev· November 2009

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A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.
Anne S Kienhuis, Marcel C G van de Poll, Cornelis H C Dejong, Ralph Gottschalk, Marcel van Herwijnen

Toxicol In Vitro· September 2009

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Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.
Hans B Ketelslegers, Roger W L Godschalk, Bart J M Eskens, Jan W Dallinga, Ralph W H Gottschalk

Mol Carcinog· August 2009

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Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
Anne S Kienhuis, Marcel C G van de Poll, Heleen Wortelboer, Marcel van Herwijnen, Ralph Gottschalk

Toxicol Sci· February 2009

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Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices.
Yvonne C M Staal, Daphnee S Pushparajah, Marcel H M van Herwijnen, Ralph W H Gottschalk, Lou M Maas

Mutagenesis· November 2008

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Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies.
Danitsja M van Leeuwen, Ralph W H Gottschalk, Greet Schoeters, Nicolas A van Larebeke, Vera Nelen

Environ Health Perspect· November 2008

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Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study.
Hans B Ketelslegers, Ralph W H Gottschalk, Gudrun Koppen, Greet Schoeters, Willy F Baeyens

Cancer Epidemiol Biomarkers Prev· August 2008

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Genomic analysis suggests higher susceptibility of children to air pollution.
Danitsja M van Leeuwen, Marie Pedersen, Peter J M Hendriksen, André Boorsma, Marcel H M van Herwijnen, Ralph W H Gottschalk

Carcinogenesis· May 2008

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Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation.
Yvonne C M Staal, Dennie G A J Hebels, Marcel H M van Herwijnen, Ralph W H Gottschalk, Frederik J van Schooten

Carcinogenesis· December 2007

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Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.
Liesbeth Geraets, Harald J J Moonen, Karen Brauers, Ralph W H Gottschalk, Emiel F M Wouters

Eur J Pharmacol· November 2007

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The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.
Ad M Knaapen, Daniëlle M Curfs, Daniëlle M Pachen, Ralph W Gottschalk, Menno P J de Winther

Mutat Res· August 2007

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Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers.
Lonneke C Wilms, Agnes W Boots, Vincent C J de Boer, Lou M Maas, Daniëlle M F A Pachen, Ralph W H Gottschalk

Carcinogenesis· August 2007

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Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs.
Danitsja M van Leeuwen, Ebienus van Agen, Ralph W H Gottschalk, Robert Vlietinck, Marij Gielen

Carcinogenesis· March 2007

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The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.
Sabine A S Langie, Ad M Knaapen, Joyce M J Houben, Frederik C van Kempen, Joep P J de Hoon, Ralph W H Gottschalk

Toxicol Lett· February 2007

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