Publications by authors named "Ramakrishna Seethala"

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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).
Jun Li, Lawrence J Kennedy, Steven J Walker, Haixia Wang, James J Li, Ramakrishna Seethala

ACS Med Chem Lett· December 2018

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Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Ramakrishna Seethala

J Med Chem· June 2017

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Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders.
David S Yoon, Shung C Wu, Ramakrishna Seethala, Rajasree Golla, Akbar Nayeem

Bioorg Med Chem Lett· November 2014

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Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).
Jun Li, Lawrence J Kennedy, Haixia Wang, James J Li, Steven J Walker, Ramakrishna Seethala

ACS Med Chem Lett· July 2014

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Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
Xiang-Yang Ye, David Yoon, Stephanie Y Chen, Akbar Nayeem, Rajasree Golla, Ramakrishna Seethala

Bioorg Med Chem Lett· January 2014

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Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.
Michael M Miller, Yalei Liu, Ji Jiang, James A Johnson, Muthoni Kamau, Ramakrishna Seethala

Bioorg Med Chem Lett· October 2012

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Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).
Xiang-Yang Ye, Stephanie Y Chen, Akbar Nayeem, Rajasree Golla, Ramakrishna Seethala

Bioorg Med Chem Lett· November 2011

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Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).
Shung C Wu, David Yoon, Janice Chin, Katy van Kirk, Ramakrishna Seethala

Bioorg Med Chem Lett· November 2011

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Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).
Haixia Wang, Jeffrey A Robl, Lawrence G Hamann, Ligaya Simpkins, Rajasree Golla, Ramakrishna Seethala

Bioorg Med Chem Lett· July 2011

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Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
Claudio Mapelli, Sesha I Natarajan, Jean-Philippe Meyer, Margarita M Bastos, Michael S Bernatowicz, Ramakrishna Seethala

J Med Chem· December 2009

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Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Tasir S Haque, Ningning Liang, Rajasree Golla, Ramakrishna Seethala, Zhengping Ma

Bioorg Med Chem Lett· October 2009

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N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
Alexandra A Nirschl, Yan Zou, Stanley R Krystek, James C Sutton, Ligaya M Simpkins, Ramakrishna Seethala

J Med Chem· May 2009

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Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists.
Wu Yang, Zheming Ruan, Yufeng Wang, Katy Van Kirk, Zhengping Ma, Ramakrishna Seethala

J Med Chem· February 2009

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A simple homogeneous scintillation proximity assay for acyl-coenzyme A:diacylglycerol acyltransferase.
Ramakrishna Seethala, Tara Peterson, Jessica Dong, Ching-Hsuen Chu, Luping Chen

Anal Biochem· December 2008

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Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.
Dong Cheng, Jahangir Iqbal, James Devenny, Ching-Hsuen Chu, Luping Chen, Ramakrishna Seethala

J Biol Chem· October 2008

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(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.
Jun Li, Stephanie Y Chen, Brian J Murphy, Neil Flynn, Ramakrishna Seethala

Bioorg Med Chem Lett· July 2008

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Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Haixia Wang, Zheming Ruan, James J Li, Ligaya M Simpkins, Rebecca A Smirk, Ramakrishna Seethala

Bioorg Med Chem Lett· June 2008

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2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.
Lalgudi S Harikrishnan, Muthoni G Kamau, Timothy F Herpin, George C Morton, Yalei Liu, Ramakrishna Seethala

Bioorg Med Chem Lett· April 2008

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Tetrazole based amides as growth hormone secretagogues.
James J Li, Haixia Wang, Jun Li, Fucheng Qu, Stephen G Swartz, Ramakrishna Seethala

Bioorg Med Chem Lett· April 2008

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Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.
Jun Li, Stephanie Y Chen, Shiwei Tao, Haixia Wang, James J Li, Ramakrishna Seethala

Bioorg Med Chem Lett· March 2008

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Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Jun Li, Stephanie Y Chen, James J Li, Haixia Wang, Andres S Hernandez, Ramakrishna Seethala

J Med Chem· November 2007

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Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.
Bhavana Sahni-Arya, Michael J Flynn, Laurie Bergeron, Mary Ellen K Salyan, Donna L Pedicord, Ramakrishna Seethala

Biochim Biophys Acta· September 2007

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Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.
Mark C Manfredi, Yingzhi Bi, Alexandra A Nirschl, James C Sutton, Ramakrishna Seethala

Bioorg Med Chem Lett· August 2007

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Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.
James J Li, James C Sutton, Alexandra Nirschl, Yan Zou, Haixia Wang, Ramakrishna Seethala

J Med Chem· June 2007

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A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
Ramakrishna Seethala, Rajasree Golla, Zhengping Ma, Hao Zhang, Kevin O'Malley

Anal Biochem· April 2007

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