Publications by authors named "Ramkumar Kavya"

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The impact of targeting TRAF2 and NCK-interacting protein kinase (TNIK) on anti-tumor effect and tumor immune environment in c-MYC-high small cell lung cancer.
Azusa Tanimoto, Kavya Ramkumar, C Allison Stewart, Bingnan Zhang, Kyle Concannon

J Thorac Oncol· December 2025

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YAP1 defines an emergent, plastic population of relapsed small cell lung cancer.
C Allison Stewart, Kavya Ramkumar, Runsheng Wang, Yuanxin Xi, Alexa Halliday

bioRxiv· October 2025

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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer.
Ana Galan-Cobo, Natalie I Vokes, Yu Qian, David Molkentine, Kavya Ramkumar

Cancer Cell· August 2025

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DNA-PK inhibition sustains the antitumor innate immune response in small cell lung cancer.
Caterina De Rosa, Floriana Morgillo, Luisa Amato, Francesca Iommelli, Viviana De Rosa, Kavya Ramkumar

iScience· March 2025

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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer.
Benjamin B Morris, Simon Heeke, Yuanxin Xi, Lixia Diao, Qi Wang, Kavya Ramkumar

Mol Cancer· March 2025

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YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.
C Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar

Clin Cancer Res· October 2024

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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.
Clare E Murray, Anand V R Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Kavya Ramkumar

Mol Cancer· October 2024

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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer.
Benjamin B Morris, Simon Heeke, Yuanxin Xi, Lixia Diao, Qi Wang, Kavya Ramkumar

bioRxiv· July 2024

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Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer.
Kavya Ramkumar, Azusa Tanimoto, Carminia M Della Corte, C Allison Stewart, Qi Wang

Clin Cancer Res· August 2023

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Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC.
Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli

J Transl Med· November 2022

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Anti-tumor activity of cetuximab plus avelumab in non-small cell lung cancer patients involves innate immunity activation: findings from the CAVE-Lung trial.
Carminia Maria Della Corte, Morena Fasano, Vincenza Ciaramella, Flora Cimmino, Robert Cardnell, Kavya Ramkumar

J Exp Clin Cancer Res· March 2022

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Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.
C Allison Stewart, Carl M Gay, Kavya Ramkumar, Kasey R Cargill, Robert J Cardnell

J Thorac Oncol· November 2021

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A wake-up call for cancer DNA damage: the role of Schlafen 11 (SLFN11) across multiple cancers.
Bingnan Zhang, Kavya Ramkumar, Robert John Cardnell, Carl Michael Gay, C Allison Stewart

Br J Cancer· November 2021

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SLFN11 biomarker status predicts response to lurbinectedin as a single agent and in combination with ATR inhibition in small cell lung cancer.
Kiran Kundu, Robert J Cardnell, Bingnan Zhang, Li Shen, C Allison Stewart, Kavya Ramkumar

Transl Lung Cancer Res· November 2021

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Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer.
Kasey R Cargill, C Allison Stewart, Elizabeth M Park, Kavya Ramkumar, Carl M Gay

Cancer Metab· September 2021

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The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer.
Soma Samanta, Suhui Yang, Bikash Debnath, Ding Xue, Yuting Kuang, Kavya Ramkumar

Cancer Res· April 2021

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AXL Inhibition Induces DNA Damage and Replication Stress in Non-Small Cell Lung Cancer Cells and Promotes Sensitivity to ATR Inhibitors.
Kavya Ramkumar, C Allison Stewart, Kasey R Cargill, Carminia M Della Corte, Qi Wang

Mol Cancer Res· March 2021

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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.
Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Kavya Ramkumar

Cancer Cell· March 2021

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Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology.
C Allison Stewart, Carl M Gay, Kavya Ramkumar, Kasey R Cargill, Robert J Cardnell

bioRxiv· January 2021

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STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.
Carminia M Della Corte, Triparna Sen, Carl M Gay, Kavya Ramkumar, Lixia Diao

J Thorac Oncol· May 2020

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Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC.
Triparna Sen, Carminia M Della Corte, Snezana Milutinovic, Robert J Cardnell, Lixia Diao, Kavya Ramkumar

J Thorac Oncol· December 2019

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Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.
Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura

Nat Commun· October 2016

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Design, synthesis and screening studies of potent thiazol-2-amine derivatives as fibroblast growth factor receptor 1 inhibitors.
B V S Suneel Kumar, Narasu Lakshmi, M Ravi Kumar, Gundla Rambabu, Thimmappa H Manjashetty, Kavya Ramkumar

Curr Top Med Chem· June 2015

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Design, synthesis and structure-activity studies of rhodanine derivatives as HIV-1 integrase inhibitors.
Kavya Ramkumar, Vladimir N Yarovenko, Alexandra S Nikitina, Igor V Zavarzin, Mikhail M Krayushkin

Molecules· June 2010

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Raltegravir: The evidence of its therapeutic value in HIV-1 infection.
Kavya Ramkumar, Nouri Neamati

Core Evid· June 2010

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