Publications by authors named "Ranjitha Uppala"

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Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis.
Meritxell Oliva, Mrinal K Sarkar, Michael E March, Amir Hossein Saeidian, Frank D Mentch, Ranjitha Uppala

Nat Commun· April 2025

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Multi-ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis.
Meritxell Oliva, Mrinal K Sarkar, Michael E March, Amir Hossein Saeidian, Frank D Mentch, Ranjitha Uppala

medRxiv· June 2024

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Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
Yanyun Jiang, Dennis Gruszka, Chang Zeng, William R Swindell, Christa Gaskill, Ranjitha Uppala

JCI Insight· March 2024

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Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa.
Kelsey R van Straalen, Feiyang Ma, Pei-Suen Tsou, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Ranjitha Uppala

J Clin Invest· February 2024

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HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
Ranjitha Uppala, Mrinal K Sarkar, Kelly Z Young, Feiyang Ma, Pritika Vemulapalli

iScience· February 2024

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Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction.
Mrinal K Sarkar, Ranjitha Uppala, Chang Zeng, Allison C Billi, Lam C Tsoi

J Clin Invest· May 2023

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Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes.
Alexander A Merleev, Stephanie T Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Ranjitha Uppala

JCI Insight· August 2022

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Noninvasive Tape-Stripping with High-Resolution RNA Profiling Effectively Captures a Preinflammatory State in Nonlesional Psoriatic Skin.
Lam C Tsoi, Xianying Xing, Enze Xing, Rachael Wasikowski, Shuai Shao, Ranjitha Uppala

J Invest Dermatol· June 2022

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Cytokine responses in nonlesional psoriatic skin as clinical predictor to anti-TNF agents.
Lam C Tsoi, Matthew T Patrick, Shao Shuai, Mrinal K Sarkar, Sunyi Chi, Ranjitha Uppala

J Allergy Clin Immunol· February 2022

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IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.
Shuai Shao, Lam C Tsoi, William R Swindell, Jiaoling Chen, Ranjitha Uppala

J Invest Dermatol· October 2021

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Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris.
Shuai Shao, Jiaoling Chen, William R Swindell, Lam C Tsoi, Xianying Xing, Ranjitha Uppala

JCI Insight· October 2021

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Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.
Liviu I Moldovan, Lam C Tsoi, Uppala Ranjitha, Henrik Hager, Stephen Weidinger

Exp Dermatol· August 2021

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"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.
Ranjitha Uppala, Lam C Tsoi, Paul W Harms, Bo Wang, Allison C Billi

Cell Mol Immunol· February 2021

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NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
Cory L Simpson, Mariko K Tokito, Ranjitha Uppala, Mrinal K Sarkar, Johann E Gudjonsson

Cell Rep· February 2021

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KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Allison C Billi, Jessica E Ludwig, Yi Fritz, Richard Rozic, William R Swindell, Ranjitha Uppala

J Clin Invest· June 2020

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Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses.
Lam C Tsoi, Elke Rodriguez, Dora Stölzl, Ulrike Wehkamp, Jingru Sun, Ranjitha Uppala

J Allergy Clin Immunol· May 2020

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IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
Jeffery T Kwock, Chelsea Handfield, Jutamas Suwanpradid, Peter Hoang, Michael J McFadden, Ranjitha Uppala

Sci Adv· April 2020

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IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus.
Shuai Shao, Lam C Tsoi, Mrinal K Sarkar, Xianying Xing, Ke Xue, Ranjitha Uppala

Sci Transl Med· September 2019

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Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.
Lam C Tsoi, Elke Rodriguez, Frauke Degenhardt, Hansjörg Baurecht, Ulrike Wehkamp, Ranjitha Uppala

J Invest Dermatol· July 2019

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Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.
Lam C Tsoi, Grace A Hile, Celine C Berthier, Mrinal K Sarkar, Tamra J Reed, Ranjitha Uppala

J Immunol· April 2019

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The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.
Allison C Billi, Mehrnaz Gharaee-Kermani, Joseph Fullmer, Lam C Tsoi, Brett D Hill, Ranjitha Uppala

JCI Insight· April 2019

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Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.
Mrinal K Sarkar, Grace A Hile, Lam C Tsoi, Xianying Xing, Jianhua Liu, Ranjitha Uppala

Ann Rheum Dis· November 2018

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