Publications by authors named "Raphael Ceccaldi"

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Repair Pathway Choices and Consequences at the Double-Strand Break.
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea

Trends Cell Biol· January 2016

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Mechanisms and regulation of DNA end resection in the maintenance of genome stability.
Raphael Ceccaldi, Petr Cejka

Nat Rev Mol Cell Biol· August 2025

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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors.
Daniele Musiani, Hatice Yücel, Marie Vallette, Annapaola Angrisani, Rania El Botty, Raphael Ceccaldi

Mol Cell· March 2025

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Publisher Correction: Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
Camille Gelot, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Raphael Ceccaldi

Nature· February 2024

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DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C.
Marton Tibor Kovacs, Marie Vallette, Pauline Wiertsema, Florent Dingli, Damarys Loew, Raphael Ceccaldi

Mol Cell· October 2023

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Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
Camille Gelot, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Raphael Ceccaldi

Nature· September 2023

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A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells.
Sara Berrada, Elena Martínez-Balsalobre, Lise Larcher, Violette Azzoni, Nadia Vasquez, Raphaël Ceccaldi

Nucleic Acids Res· August 2023

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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
Jia Zhou, Camille Gelot, Constantia Pantelidou, Adam Li, Hatice Yücel, Raphael Ceccaldi

Nat Cancer· June 2021

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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.
Sara Przetocka, Antonio Porro, Hella A Bolck, Christina Walker, Aleksandra Lezaja, Raphael Ceccaldi

Mol Cell· November 2018

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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Beatrice Rondinelli, Ewa Gogola, Hatice Yücel, Alexandra A Duarte, Marieke van de Ven, Raphaël Ceccaldi

Nat Cell Biol· November 2017

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Biallelic inactivation of REV7 is associated with Fanconi anemia.
Dominique Bluteau, Julien Masliah-Planchon, Connor Clairmont, Alix Rousseau, Raphael Ceccaldi

J Clin Invest· March 2017

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Biallelic inactivation of REV7 is associated with Fanconi anemia.
Dominique Bluteau, Julien Masliah-Planchon, Connor Clairmont, Alix Rousseau, Raphael Ceccaldi

J Clin Invest· September 2016

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The Fanconi anaemia pathway: new players and new functions.
Raphael Ceccaldi, Prabha Sarangi, Alan D D'Andrea

Nat Rev Mol Cell Biol· June 2016

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FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O'Leary, David Kozono, Raphael Ceccaldi

Cell Rep· June 2016

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Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.
Panagiotis A Konstantinopoulos, Raphael Ceccaldi, Geoffrey I Shapiro, Alan D D'Andrea

Cancer Discov· November 2015

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A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance.
Raphael Ceccaldi, Kevin W O'Connor, Kent W Mouw, Adam Y Li, Ursula A Matulonis

Cancer Res· February 2015

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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack

Nature· February 2015

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Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.
Hyungjin Kim, Donniphat Dejsuphong, Guillaume Adelmant, Raphael Ceccaldi, Kailin Yang

Mol Cell· April 2014

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A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients.
Séverine Lecourt, Enguerran Mouly, Delphine Freida, Audrey Cras, Raphaël Ceccaldi

PLoS One· March 2014

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Gene polymorphisms and cytokine plasma levels as predictive factors of complications after cardiopulmonary bypass.
Jérôme Jouan, Lisa Golmard, Nadine Benhamouda, Nicolas Durrleman, Jean-Louis Golmard, Raphaël Ceccaldi

J Thorac Cardiovasc Surg· August 2012

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Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.
Raphael Ceccaldi, Kalindi Parmar, Enguerran Mouly, Marc Delord, Jung Min Kim

Cell Stem Cell· July 2012

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Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.
Samuel Quentin, Wendy Cuccuini, Raphael Ceccaldi, Olivier Nibourel, Corinne Pondarre

Blood· April 2011

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Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.
Raphael Ceccaldi, Delphine Briot, Jérôme Larghero, Nadia Vasquez, Catherine Dubois d'Enghien

J Clin Invest· January 2011

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