Publications by authors named "Ray Dingledine"

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Neuroinflammation and Disease: Pathways and Opportunities.
Olivia Hoffman, Nicholas H Varvel, Avtar S Roopra, Ray Dingledine

Annu Rev Pharmacol Toxicol· September 2025

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CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures.
Soheila Pourkhodadad, Wenyi Wang, Ray Dingledine, Nicholas H Varvel

bioRxiv· May 2025

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Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor.
Robert Zaczek, Stephen F Traynelis, Ray Dingledine, George W Koszalka, Daniel T Laskowitz

Clin Pharmacol Drug Dev· July 2023

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P2X7 Forges Ahead in Neonatal Hypoxia.
Ray Dingledine

Epilepsy Curr· May 2023

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Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus.
Carlos Alemán-Ruiz, Wenyi Wang, Ray Dingledine, Nicholas H Varvel

Sci Rep· April 2023

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Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Lynnea D Harris, Michael C Regan, Scott J Myers, Kelsey A Nocilla, Nicholas S Akins, Ray Dingledine

ACS Chem Neurosci· March 2023

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Inhibition of the prostaglandin EP2 receptor prevents long-term cognitive impairment in a model of systemic inflammation.
Chunxiang Jiang, Aysegul Caskurlu, Thota Ganesh, Ray Dingledine

Brain Behav Immun Health· October 2020

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An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors.
Chunxiang Jiang, Radhika Amaradhi, Thota Ganesh, Ray Dingledine

ACS Chem Neurosci· May 2020

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Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.
Radhika Amaradhi, Avijit Banik, Shabber Mohammed, Vidyavathi Patro, Asheebo Rojas, Ray Dingledine

J Med Chem· February 2020

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Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Jianxiong Jiang, Ying Yu, Erika Reime Kinjo, Yifeng Du, Hoang Phuong Nguyen, Ray Dingledine

Neuropharmacology· May 2019

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Why Is It so Hard to Do Good Science?
Ray Dingledine

eNeuro· April 2019

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Peripherally Restricted, Highly Potent, Selective, Aqueous-Soluble EP2 Antagonist with Anti-Inflammatory Properties.
Thota Ganesh, Avijit Banik, Ray Dingledine, Wenyi Wang, Radhika Amaradhi

Mol Pharm· December 2018

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A New Approach for Epilepsy.
Ray Dingledine, Bjørnar Hassel

Cerebrum· July 2016

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2014 Epilepsy Benchmarks: Progress and Opportunities.
Cara Long, Brandy Fureman, Ray Dingledine

Epilepsy Curr· June 2016

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2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions.
Rochelle Caplan, Heather Mefford, Madison Berl, Bernard Chang, Jack Lin, Ray Dingledine

Epilepsy Curr· June 2016

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2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression.
Aristea S Galanopoulou, Michael Wong, Devin Binder, Adam L Hartman, Elizabeth M Powell, Ray Dingledine

Epilepsy Curr· June 2016

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2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
Dennis Dlugos, Greg Worrell, Kathryn Davis, William Stacey, Jerzy Szaflarski, Ray Dingledine

Epilepsy Curr· June 2016

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2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across The Lifespan.
Alica M Goldman, W Curt LaFrance, Tim Benke, Miya Asato, Dan Drane, Ray Dingledine

Epilepsy Curr· June 2016

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The First 50 Years of Molecular Pharmacology.
Joan Heller Brown, William A Catterall, P Jeffrey Conn, Stuart G Cull-Candy, Ray Dingledine

Mol Pharmacol· July 2015

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When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?
Ray Dingledine, Nicholas H Varvel, F Edward Dudek

Adv Exp Med Biol· November 2014

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Development of second generation EP2 antagonists with high selectivity.
Thota Ganesh, Jianxiong Jiang, Ray Dingledine

Eur J Med Chem· July 2014

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Lead optimization studies of cinnamic amide EP2 antagonists.
Thota Ganesh, Jianxiong Jiang, Myung-Soon Yang, Ray Dingledine

J Med Chem· May 2014

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Discovery and characterization of carbamothioylacrylamides as EP selective antagonists.
Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy, Ray Dingledine

ACS Med Chem Lett· July 2013

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