Publications by authors named "Ray Jade Chen"

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Naphthalimide derivative attenuates tumor growth of wild-type p53-expressing U87 glioma cells in vitro and in vivo through a biphasic dose-dependent mechanism: A switch from cell cycle to apoptosis.
Kuan-Hung Lin, Jiun-Yi Li, Ray-Jade Chen, Yun-Ju Wang, Hsueh-Hsiao Wang

Biomed Pharmacother· June 2025

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A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency.
Wan-Jung Lu, Jiun-Yi Li, Tzenge-Lien Shih, Ray-Jade Chen, Ting-Yu Chen

Front Pharmacol· June 2025

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Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats.
Ray-Jade Chen, Ming-Cheng Chen, Bruce Chi-Kang Tsai, Rakesh Roy, Yi-Ru Chang, Chi-Cheng Li

Chem Biol Drug Des· December 2023

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Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis.
Kuan-Hung Lin, Jiun-Yi Li, Ray-Jade Chen, Ting-Yu Chen, Shao-Hsuan Hsu

Thromb Res· May 2023

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Tannic acid attenuate AKT phosphorylation to inhibit UMUC3 bladder cancer cell proliferation.
Ming-Cheng Chen, Selvaraj Annseles Rajula, V Bharath Kumar, Chiung-Hung Hsu, Cecilia Hsuan Day, Ray-Jade Chen, Chi-Cheng Li

Mol Cell Biochem· December 2022

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Angiotensin II prompts heart cell apoptosis via AT1 receptor-augmented phosphatase and tensin homolog and miR-320-3p functions to enhance suppression of the IGF1R-PI3K-AKT survival pathway.
Shang-Yeh Lu, Wei-Zhi Hong, Bruce Chi-Kang Tsai, Yu-Chun Chang, Chia-Hua Kuo, Ray-Jade Chen

J Hypertens· December 2022

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Low-dose rapamycin prevents Ang-II-induced toxicity in Leydig cells and testicular dysfunction in hypertensive SHR model.
Wei-Wen Kuo, Rathinasamy Baskaran, Jing-Ying Lin, Cecilia Hsuan Day, Yueh-Min Lin, Ray-Jade Chen

J Biochem Mol Toxicol· September 2022

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Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation.
Wan-Jung Lu, Chung-Hsin Tsai, Ray-Jade Chen, Li-Ting Huang, Ting-Yu Chen, Lih-Chyang Chen

Biomed Pharmacother· September 2022

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Protective effects of CHIP overexpression and Wharton's jelly mesenchymal-derived stem cell treatment against streptozotocin-induced neurotoxicity in rats.
Da-Tong Ju, Dao Van Thao, Cheng-You Lu, Ayaz Ali, Marthandam Asokan Shibu, Ray-Jade Chen, Cheng-Yen Tsai

Environ Toxicol· August 2022

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Isoliquiritigenin ameliorates advanced glycation end-products toxicity on renal proximal tubular epithelial cells.
Chin-Yi Lin, Yu-Cheng Lin, Catherine Reena Paul, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Ray-Jade Chen

Environ Toxicol· August 2022

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Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis.
Chih-Yang Huang, Yi-Chen Su, Cheng-You Lu, Ping-Ling Chiu, Yung-Ming Chang, Ray-Jade Chen

Environ Toxicol· July 2022

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Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity.
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Ray-Jade Chen

Int J Biol Sci· July 2022

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Association of Air Pollution and Weather Factors with Traffic Injury Severity: A Study in Taiwan.
Ta-Chien Chan, Chih-Wei Pai, Chia-Chieh Wu, Jason C Hsu, Ray-Jade Chen

Int J Environ Res Public Health· June 2022

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Calycosin alleviates H O -induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway.
Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Ray-Jade Chen

Environ Toxicol· April 2022

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Determining Carina and Clavicular Distance-Dependent Positioning of Endotracheal Tube in Critically Ill Patients: An Artificial Intelligence-Based Approach.
Lung-Wen Tsai, Kuo-Ching Yuan, Sen-Kuang Hou, Wei-Lin Wu, Chen-Hao Hsu, Hann-Chyun Chen, Ray-Jade Chen

Biology (Basel)· March 2022

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Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-ζ to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression.
Hung-Jen Lin, Ramasamy Mahendran, Hsiang-Yen Huang, Ping-Ling Chiu, Yung-Ming Chang, Ray-Jade Chen

J Ethnopharmacol· February 2022

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Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague-Dawley rats.
Tsung-Jung Ho, Bruce Chi-Kang Tsai, Chia-Hua Kuo, Hsiang-Ning Luk, Cecilia Hsuan Day, Ray-Jade Chen

Chem Biol Interact· February 2022

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Perturbed ER homeostasis by IGF-IIRα promotes cardiac damage under stresses.
Sudhir Pandey, Chia-Hua Kuo, William Shao-Tsu Chen, Yu-Lan Yeh, Wei-Wen Kuo, Ray-Jade Chen

Mol Cell Biochem· January 2022

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Exploring the COVID-19 Pandemic as a Catalyst for Behavior Change Among Patient Health Record App Users in Taiwan: Development and Usability Study.
Chinyang Henry Tseng, Ray-Jade Chen, Shang-Yu Tsai, Tsung-Ren Wu, Woei-Jiunn Tsaur, Cheng-Yi Yang

J Med Internet Res· January 2022

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Leu IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling.
Chin-Yi Lin, Marthandam Asokan Shibu, Renee Wen, Cecilia Hsuan Day, Ray-Jade Chen

Environ Toxicol· December 2021

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The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats.
Chang-Wen Ku, Cecilia Hsuan Day, Hsiu-Chung Ou, Tsung-Jung Ho, Ray-Jade Chen

Open Life Sci· November 2021

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A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI.
Tzenge-Lien Shih, Kuan-Hung Lin, Ray-Jade Chen, Ting-Yu Chen, Wei-Ting Kao

J Cell Mol Med· October 2021

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CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells attenuate hyperglycemia-induced oxidative stress-mediated kidney injuries in diabetic rats.
Ayaz Ali, Marthandam Asokan Shibu, Chia-Hua Kuo, Jeng-Feng Lo, Ray-Jade Chen

Free Radic Biol Med· September 2021

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Influence of Vincristine, Clinically Used in Cancer Therapy and Immune Thrombocytopenia, on the Function of Human Platelets.
Li-Ming Lien, Wan-Jung Lu, Kuan-Hung Lin, Ling-Hsuan Kang, Ting-Yu Chen, Hsuan Chen, Ray-Jade Chen

Molecules· September 2021

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Correction: A COVID-19 Pandemic Artificial Intelligence-Based System With Deep Learning Forecasting and Automatic Statistical Data Acquisition: Development and Implementation Study.
Cheng-Sheng Yu, Shy-Shin Chang, Tzu-Hao Chang, Jenny L Wu, Yu-Jiun Lin, Ray-Jade Chen

J Med Internet Res· July 2021

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