Publications by authors named "Raymond G Booth"

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Oxycodone self-administration and drug-primed responding in male and female squirrel monkeys: Effects of alternative reinforcer availability.
Fernando B de Moura, Raymond G Booth, Stephen J Kohut

J Pharmacol Exp Ther· November 2025

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Development of 2-Aminotetralin-Type Serotonin 5-HT Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT, 5-HT, 5-HT, and 5-HT Receptors.
Ryan P McGlynn, Meng Cui, Brittany Brems, Otto Holbrook, Raymond G Booth

ACS Chem Neurosci· January 2024

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Effects of (-)-MBP, a novel 5-HT agonist and 5-HT antagonist/inverse agonist on brain activity: A phMRI study on awake mice.
Preeti K Sathe, Gargi R Ramdasi, Kaylie Giammatteo, Harvens Beauzile, Shuyue Wang, Raymond G Booth

Pharmacol Res Perspect· October 2023

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Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.
Nicholas R Fragola, Brittany M Brems, Munmun Mukherjee, Meng Cui, Raymond G Booth

ACS Chem Neurosci· May 2023

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Oxycodone self-administration and reinstatement in male and female squirrel monkeys: Effects of alternative reinforcer availability.
Fernando B de Moura, Raymond G Booth, Stephen J Kohut

bioRxiv· January 2023

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FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT, 5-HT, and 5-HT Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Knockout Mice.
Tanishka S Saraf, Ryan P McGlynn, Omkar M Bhatavdekar, Raymond G Booth, Clinton E Canal

ACS Chem Neurosci· December 2022

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A new class of 5-HT /5-HT receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins.
Austen B Casey, Munmun Mukherjee, Ryan P McGlynn, Meng Cui, Stephen J Kohut, Raymond G Booth

Br J Pharmacol· June 2022

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"Selective" serotonin 5-HT receptor antagonists.
Austen B Casey, Meng Cui, Raymond G Booth, Clinton E Canal

Biochem Pharmacol· June 2022

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Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.
Tanishka S Saraf, Daniel E Felsing, Jessica L Armstrong, Raymond G Booth, Clinton E Canal

Epilepsy Res· September 2021

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()-5-(2'-Fluorophenyl)-,-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
Jessica L Armstrong, Austen B Casey, Tanishka S Saraf, Munmun Mukherjee, Raymond G Booth

ACS Pharmacol Transl Sci· June 2020

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Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT and 5-HT G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.
Charles K Perry, Austen B Casey, Daniel E Felsing, Rajender Vemula, Mehreen Zaka, Raymond G Booth

Bioorg Med Chem· February 2020

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Ligand-directed serotonin 5-HT receptor desensitization and sensitization.
Daniel E Felsing, Clinton E Canal, Raymond G Booth

Eur J Pharmacol· April 2019

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Mutagenesis Analysis Reveals Distinct Amino Acids of the Human Serotonin 5-HT Receptor Underlying the Pharmacology of Distinct Ligands.
Yue Liu, Clinton E Canal, Tania C Cordova-Sintjago, Wanying Zhu, Raymond G Booth

ACS Chem Neurosci· January 2017

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Correction to an orally active phenylaminotetralin-chemotype serotonin 5-HT7 and 5-HT1A receptor partial agonist that corrects motor stereotypy in mouse models.
Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Raymond G Booth

ACS Chem Neurosci· August 2015

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An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models.
Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Raymond G Booth

ACS Chem Neurosci· July 2015

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Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.
Rajeev Sakhuja, Krishnakanth Kondabolu, Tania Córdova-Sintjago, Sean Travers, Adam S Vincek, Raymond G Booth

Bioorg Med Chem· April 2015

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Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
James M Kasper, Raymond G Booth, Joanna Peris

Synapse· February 2015

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A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.
Clinton E Canal, Drake Morgan, Daniel Felsing, Krishnakanth Kondabolu, Neil E Rowland, Raymond G Booth

J Pharmacol Exp Ther· May 2014

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Aromatic interactions impact ligand binding and function at serotonin 5-HT G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies.
Tania Córdova-Sintjago, Nancy Villa, Lijuan Fang, Raymond G Booth

Mol Phys· January 2014

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Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands.
Clinton E Canal, Tania Cordova-Sintjago, Yue Liu, Myong S Kim, Drake Morgan, Raymond G Booth

J Pharmacol Exp Ther· December 2013

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Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications.
Drake Morgan, Krishnakanth Kondabolu, Allison Kuipers, Rajeev Sakhuja, Kimberly L Robertson, Raymond G Booth

Neuropharmacology· September 2013

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Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model.
Clinton E Canal, Raymond G Booth, Drake Morgan

Neuropharmacology· July 2013

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Molecular Determinants for Ligand Binding at Serotonin 5-HT and 5-HT GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies.
Tania Córdova-Sintjago, Rajeev Sakhuja, Krishnakanth Kondabolu, Clinton E Canal, Raymond G Booth

Int J Quantum Chem· December 2012

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Molecular determinants of ligand binding at the human histamine H receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H homology and crystal structure models.
Tania C Cordova-Sintjago, Lijuan Fang, Martijn Bruysters, Rob Leurs, Raymond G Booth

J Chem Pharm Res· June 2012

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Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation.
Clinton E Canal, Tania C Cordova-Sintjago, Nancy Y Villa, Li-Juan Fang, Raymond G Booth

Eur J Pharmacol· December 2011

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