Publications by authors named "Reem Arafa"

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Pyrazolo[1,5-a]pyrimidine scaffold-based small molecules: From bench to FDA-approved TRK kinase inhibitors (Part 1).
Mustafa A Al-Qadhi, Tawfeek A A Yahya, Anas A Alqadhi, Reem K Arafa

Eur J Med Chem· January 2026

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Synergistic Neuroprotection in Tauopathic Mice via Green-Synthesized Silver Nanoparticles Co-delivering Methylene Blue and Moringa oleifera.
Yasmin Elbermawy, Sara El-Desouky, Reem K Arafa, Sara Elfarrash, Ahmad Bassiouny

Mol Neurobiol· December 2025

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Discovery of indole- and quinolone-based inhibitors of the mTOR/Akt/Pi3K pathway for the potential treatment of autism and certain types of cancer.
Ahmad Elshahary, Hesham Safwan, Ahmad Abdelwaly, Reem K Arafa, Mohamed A Helal

RSC Med Chem· October 2025

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Evaluating the structure-based virtual screening performance of SARS-CoV-2 main protease: A benchmarking approach and a multistage screening example against the wild-type and Omicron variants.
Noha Galal, Botros Y Beshay, Omar Soliman, Muhammad I Ismail, Mohamed Abdelfadil, Reem K Arafa

PLoS One· May 2025

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Structure-based design of new anticancer N3-Substituted quinazolin-4-ones as type I ATP-competitive inhibitors targeting the deep hydrophobic pocket of EGFR.
Ragaa Y El-Mahdy, Noha Galal, Rahma Lotfy, Reem K Arafa

Comput Biol Med· March 2025

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Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents.
Ebtessam A Basiony, Allam A Hassan, Mohamed Elsawalhy, Adel A-H Abdel-Rahman, Hayam Mansour, Reem K Arafa

Bioorg Chem· January 2025

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Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR-2 Inhibitors Based on the Benzenesulfonamide-Bearing 4-Thiazolidinones/2,4-Thiazolidinediones Scaffold.
Merve Zengin, Oya Unsal Tan, Suna Sabuncuoglu, Reem K Arafa, Ayla Balkan

Drug Dev Res· December 2024

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Development and validation of an LC‒MS/MS method for the determination of cyclocreatine phosphate and its related endogenous biomolecules in rat heart tissues.
Ibrahim F Abo-Elmagd, Amr M Mahmoud, Medhat A Al-Ghobashy, Marianne Nebsen, Mostafa A Rabie, Reem K Arafa

BMC Chem· November 2024

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Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases (Mpro).
Florbela Pereira, Loay Bedda, Mohamed A Tammam, Abdul Kader Alabdullah, Reem Arafa

J Biomol Struct Dyn· May 2024

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Unleashing new MTDL AChE and BuChE inhibitors as potential anti-AD therapeutic agents: In vitro, in vivo and in silico studies.
Dalia Zaafar, Nehal H Elghazawy, Afnan Hassan, Mohamed Y Mahmoud, Alaa F Bakr, Reem K Arafa

Int J Biol Macromol· May 2024

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Exploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation.
Nourhan M Aboomar, Omar Essam, Afnan Hassan, Ahmad R Bassiouny, Reem K Arafa

Sci Rep· April 2024

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Metabolite Profiling of via UPLC-ESI-QTOF-MS Analysis in Correlation to the In Vitro Antioxidant and Cytotoxic Potential against A549 Non-Small Cell Lung Cancer Cell Line.
Álvaro Fernández-Ochoa, Inas Y Younis, Reem K Arafa, María de la Luz Cádiz-Gurrea, Francisco Javier Leyva-Jiménez

Plants (Basel)· March 2024

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Gamma Secretase as an Important Drug Target for Management of Alzheimer's Disease: A Comprehensive Review.
Fady Tadros Hakem, Youstina Farid Fouad, Reem K Arafa

Curr Top Med Chem· February 2024

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Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy.
Shoaib Manzoor, Moustafa T Gabr, Mohamed S Nafie, Md Kausar Raza, Ashma Khan, Reem K Arafa

ACS Chem Neurosci· February 2024

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Designing Potent Anti-Cancer Agents: Synthesis and Molecular Docking Studies of Thieno[2,3-][1,2,4]triazolo[1,5-]pyrimidine Derivatives.
Eman S M Elsenbawy, Zafer S Alshehri, Nouf A Babteen, Adel A-H Abdel-Rahman, Mai A El-Manawaty, Reem K Arafa

Molecules· February 2024

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Computer-assisted drug discovery of potential natural inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase through a multi-phase approach.
Eslam B Elkaeed, Bshra A Alsfouk, Tuqa H Ibrahim, Reem K Arafa, Hazem Elkady

Antivir Ther· October 2023

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New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition.
Zeinab S El-Fakharany, Yassin M Nissan, Nada K Sedky, Reem K Arafa, Sahar M Abou-Seri

Sci Rep· July 2023

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Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation.
Anne-Sophie Castanet, Mohamed S Nafie, Sara A Said, Reem K Arafa

Eur J Med Chem· March 2023

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Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.
Haitham Hassan, Jeanne Chiavaralli, Afnan Hassan, Loay Bedda, Tim Krischuns, Reem K Arafa

RSC Med Chem· March 2023

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Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure.
Salwa A Elgebaly, Charles Van Buren, Robert Todd, Robert Poston, Reem K Arafa

Pharmaceuticals (Basel)· March 2023

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Targeting of Fascin Protein for Cancer Therapy: Benchmarking, Virtual Screening and Molecular Dynamics Approaches.
Heba H A Hassan, Muhammad I Ismail, Mohammed A S Abourehab, Frank M Boeckler, Tamer M Ibrahim, Reem K Arafa

Molecules· January 2023

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Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M).
Alaa M Elgohary, Abdo A Elfiky, Florbela Pereira, Tarek Mohamed Abd El-Aziz, Mansour Sobeh, Reem K Arafa

Comput Biol Med· August 2022

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Antibacterial and anticancer profiling of new benzocaine derivatives: Design, synthesis, and molecular mechanism of action.
Heba S A El-Zahabi, Eman S Nossier, Safya M Mousa, Heba Hassan, Al Shimaa G Shalaby, Reem K Arafa

Arch Pharm (Weinheim)· April 2022

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Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors.
Merve Zengin, Oya Unsal Tan, Reem K Arafa, Ayla Balkan

Bioorg Chem· April 2022

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Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents.
Nehal H Elghazawy, Dalia Zaafar, Reham R Hassan, Mohamed Y Mahmoud, Loay Bedda, Reem K Arafa

ACS Chem Neurosci· April 2022

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