Publications by authors named "Reinaldo Digigow"

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Sulfide silver autometallography to differentiate the ultrastructural localization of iron-carbohydrate complexes inside macrophages.
Anne-Marinette Cao, Jules Duruz, Mauro Sousa de Almeida, Dimitri Vanhecke, Amy E Alston, Reinaldo Digigow

Sci Rep· December 2025

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Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment.
Stephanie Eitner, Vera M Kissling, Alexandra Rippl, Leonard Krupnik, Justus J Bürgi, Reinaldo Digigow

J Control Release· November 2025

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Comparing iron sucrose and ferric carboxymaltose interactions with murine and human macrophages: Focus on the lysosomal compartment.
Mauro Sousa de Almeida, Amélie Bazzoni, Sandor Balog, Kata Dorbic, Céline Loussert-Fonta, Reinaldo Digigow

Eur J Pharm Sci· November 2025

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Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron-Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap.
Amy Barton Alston, Zhoumeng Lin, Heather Herd Gustafson, Beat Flühmann, Reinaldo Digigow

Clin Pharmacokinet· October 2025

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Tracking Intracellular Labile Iron with a Genetically Encoded Fluorescent Reporter System Based on Protein Stability.
Ali Akyol, Şeyma Çimen, Benjamin Gottschalk, Yusuf C Erdoğan, Anna Lischnig, Reinaldo Digigow

ACS Sens· August 2025

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Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of desmoglein 3-peptide-coupled tolerizing nanoparticles in pemphigus.
Dario Didona, Christoph Hudemann, Holger Garn, Daria Krzikalla, Shu-Hung Wang, Reinaldo Digigow

Br J Dermatol· August 2025

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Nanoparticle platform preferentially targeting liver sinusoidal endothelial cells induces tolerance in CD4+ T cell-mediated disease models.
Shu-Hung Wang, Isabelle Serr, Reinaldo Digigow, Barbara Metzler, Alexey Surnov

Front Immunol· May 2025

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Go with the flow: An in vitro model of a mature endothelium for the study of the bioresponse of IV injectable nanomedicines.
Niusha Nikravesh, Alexandra Rippl, Tobias Hoch, Stephanie Eitner, Amy Barton Alston, Reinaldo Digigow

Toxicol In Vitro· December 2024

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Nano-scale characterization of iron-carbohydrate complexes by cryogenic scanning transmission electron microscopy: Building the bridge to biorelevant characterization.
Reinaldo Digigow, Michael Burgert, Marco Luechinger, Alla Sologubenko, Andrzej J Rzepiela

Heliyon· September 2024

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Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation.
Leonard Krupnik, Jonathan Avaro, Marianne Liebi, Neda Iranpour Anaraki, Joachim Kohlbrecher, Reinaldo Digigow

J Control Release· April 2024

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Uncovering the dynamics of cellular responses induced by iron-carbohydrate complexes in human macrophages using quantitative proteomics and phosphoproteomics.
Jonas Bossart, Alexandra Rippl, Amy E Barton Alston, Beat Flühmann, Reinaldo Digigow

Biomed Pharmacother· October 2023

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Critical nanomaterial attributes of iron-carbohydrate nanoparticles: Leveraging orthogonal methods to resolve the 3-dimensional structure.
Leonard Krupnik, Prachi Joshi, Andreas Kappler, Beat Flühmann, Amy Barton Alston, Reinaldo Digigow

Eur J Pharm Sci· September 2023

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Putting square pegs in round holes: Why traditional pharmacokinetic principles cannot universally be applied to iron-carbohydrate complexes.
Amy Barton Alston, Reinaldo Digigow, Beat Flühmann, Matthias G Wacker

Eur J Pharm Biopharm· July 2023

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Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes.
Michael Burgert, Cintia Baptista Marques, Gerrit Borchard, Erik Philipp, Maria Wilhelm, Reinaldo Digigow

J Vis Exp· July 2023

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Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis.
Antonella Carambia, Cornelia Gottwick, Dorothee Schwinge, Stephanie Stein, Reinaldo Digigow

Immunology· April 2021

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