Publications by authors named "Rene Overmeer"

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Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features.
Zhijun Yu, Merel Derksen, Brigit M Te Pas, Sabrina Ladstätter, Rene Overmeer

Int J Cancer· December 2025

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Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response.
Lidwien P Smabers, Emerens Wensink, Carla S Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, René Overmeer

J Exp Clin Cancer Res· February 2024

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Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Stephanie Kourula, Merel Derksen, Ferran Jardi, Sophie Jonkers, Marjolein van Heerden, René Overmeer

Eur J Pharm Sci· September 2023

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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.
Sander Mertens, Maarten A Huismans, Carla S Verissimo, Bas Ponsioen, Rene Overmeer

Cell Rep· April 2023

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Medium-Throughput Drug- and Radiotherapy Screening Assay using Patient-Derived Organoids.
Marrit Putker, Rosemary Millen, René Overmeer, Else Driehuis, Maurice M J M Zandvliet

J Vis Exp· April 2021

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Live imaging of cell division in 3D stem-cell organoid cultures.
Ana C F Bolhaqueiro, Richard H van Jaarsveld, Bas Ponsioen, René M Overmeer, Hugo J Snippert

Methods Cell Biol· December 2018

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Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, René Overmeer

Nat Med· November 2017

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Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, René Overmeer

Nat Med· January 2017

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Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.
Carla S Verissimo, René M Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens

Elife· November 2016

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Sequential cancer mutations in cultured human intestinal stem cells.
Jarno Drost, Richard H van Jaarsveld, Bas Ponsioen, Cheryl Zimberlin, Ruben van Boxtel, René M Overmeer

Nature· May 2015

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DNA damage response and transcription.
Saskia Lagerwerf, Mischa G Vrouwe, René M Overmeer, Maria I Fousteri, Leon H F Mullenders

DNA Repair (Amst)· July 2011

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UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways.
Mischa G Vrouwe, Alex Pines, Rene M Overmeer, Katsuhiro Hanada, Leon H F Mullenders

J Cell Sci· February 2011

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Replication protein A safeguards genome integrity by controlling NER incision events.
René M Overmeer, Jill Moser, Marcel Volker, Hanneke Kool, Alan E Tomkinson

J Cell Biol· February 2011

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Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment.
René M Overmeer, Audrey M Gourdin, Ambra Giglia-Mari, Hanneke Kool, Adriaan B Houtsmuller

Mol Cell Biol· October 2010

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RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
Martijn van Hagen, René M Overmeer, Sharareh S Abolvardi, Alfred C O Vertegaal

Nucleic Acids Res· April 2010

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Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.
Tomoo Ogi, Siripan Limsirichaikul, René M Overmeer, Marcel Volker, Katsuya Takenaka

Mol Cell· March 2010

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Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.
Wouter W Wiegant, René M Overmeer, Barbara C Godthelp, Paul P W van Buul, Małgorzata Z Zdzienicka

Mutat Res· August 2006

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The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA.
Haico van Attikum, Paul Bundock, René M Overmeer, Lan-Ying Lee, Stanton B Gelvin

Nucleic Acids Res· July 2003

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