Publications by authors named "Rene Toes"

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Treatment outcomes stratified by interferon profile and autoantibodies in rheumatoid arthritis.
Shoichi Fukui, Tohru Michitsuji, Yushiro Endo, Ayako Nishino, Kaori Furukawa, René E M Toes

J Autoimmun· December 2025

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Inflammation rather than anticitrullinated protein antibodies is associated with cardiovascular mortality in RA: insights from rheumatoid arthritis and coronary artery disease cohorts.
Veerle F A M Derksen, Jane Lindschou, Per Winkel, Graciela E Delgado, Emma C de Moel, René E M Toes

Ann Rheum Dis· December 2025

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Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell-Targeting Treatment in Patients With Systemic Lupus Erythematosus.
Hugo J van Dooren, Mieke van Schaik, Annemarie L Dorjée, Eline J Arends, Meggan Mackay, René E M Toes

Arthritis Rheumatol· November 2025

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Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses.
Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Rene E M Toes

Nat Commun· November 2025

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Dimerization as a key feature of autoreactive IgA antibody responses.
Anouk G van Mourik, Jim B D Keijser, Myrthe A M van Delft, Sanne Reijm, Alice Bacon, René E M Toes

Ann Rheum Dis· November 2025

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Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens.
Haiyu Wang, Saskia Nugteren, Rick J Groenland, Stef van der Meulen, Hanneke Kapsenberg, Rene E M Toes

Ann Rheum Dis· October 2025

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Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis.
Katherine E van der Wouden, Saad Ahmed, Wieke M van Oostveen, Eva M Hoekstra, Sophie I E Liem, René E M Toes

RMD Open· October 2025

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Reply.
Wieke M van Oostveen, Eva M Hoekstra, E W Nivine Levarht, René E M Toes, Jeska K de Vries-Bouwstra

Arthritis Rheumatol· August 2025

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Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin-1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis.
Wieke M van Oostveen, Eva M Hoekstra, E W Nivine Levarht, Ilana B Kotliar, Thomas P Sakmar, René E M Toes

Arthritis Rheumatol· July 2025

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Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays.
Roxane Biersteker, Aegli Athanasiadou, Stef van der Meulen, Tineke J van Wesemael, Linda M Slot, René E M Toes

Arthritis Res Ther· July 2025

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Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation.
Roxane Biersteker, Leoni Abendstein, Sanne van de Bovenkamp, Hugo J van Dooren, Sebastiaan M W R Hamers, René E M Toes

PNAS Nexus· July 2025

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The Autoantibody response in rheumatoid arthritis; what makes it unique?
Rene E M Toes

Semin Arthritis Rheum· June 2025

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Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies.
Roxane Biersteker, Oliver F Larsen, Manfred Wuhrer, Tom W J Huizinga, René E M Toes

Semin Immunol· June 2025

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Interferon signatures fuel B cell hyperactivity and plasmablast expansion in systemic lupus erythematosus.
Hugo J van Dooren, Yemil Atisha-Fregoso, Annemarie L Dorjée, Tom W J Huizinga, Meggan Mackay, René E M Toes

J Autoimmun· June 2025

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Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype.
Anouk G van Mourik, Linda Johansson, Tineke J van Wesemael, Marc P Maurits, Heidi Kokkonen, René E M Toes

RMD Open· June 2025

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Autoreactive B cells in extremes of rheumatoid arthritis disease phenotypes.
Nienke J Blomberg, Hendy Kristyanto, Marloes Verstappen, Sam Neppelenbroek, Annette H M van der Helm-van Mil, René E M Toes

Ann Rheum Dis· June 2025

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Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies - comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis.
Tineke J van Wesemael, Fraser R Morton, Judith W Heutz, Marc P Maurits, Annemarie L Dorjée, Rene E M Toes

Arthritis Res Ther· May 2025

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Time sequence of autoimmune processes in the trajectory to rheumatoid arthritis development: what do we know?
Judith W Heutz, René E M Toes, Annette H M van der Helm-van Mil

RMD Open· May 2025

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Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity.
Constantin Blöchl, Eva Maria Stork, Hans Ulrich Scherer, Rene E M Toes, Manfred Wuhrer

Adv Sci (Weinh)· April 2025

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IgA2 ACPA Drives a Hyper-Inflammatory Phenotype in Macrophages via ATP Synthase and COX2.
Luís Almeida, Alice Bacon, Mohan Ghorasaini, Alwin J van der Ham, René E M Toes

Eur J Immunol· April 2025

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Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy.
Anika M Valk, Jana Koers, Ninotska I L Derksen, Laura Hogenboom, Zoé van Kempen, René E M Toes

Sci Rep· April 2025

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Multitiered Proteome Analysis Displays the Hyperpermeability of the Rheumatoid Synovial Compartment for Plasma Proteins.
Eva Maria Stork, Sofia Kalaidopoulou Nteak, Danique M H van Rijswijck, J Mirjam A Damen, Hans Ulrich Scherer, Rene E M Toes

Mol Cell Proteomics· February 2025

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A small-scale preliminary study utilizing mass cytometry to distinguish two forms of arthritis.
Hester Koppejan, Sophie-Anne I Smith, Marjolijn Hameetman, René E M Toes, Floris A van Gaalen

Clin Rheumatol· January 2025

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Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B-Cells.
Sanne Kroos, Nienke J Blomberg, Joanneke C Kwekkeboom, Rudi W Hendriks, Odilia B J Corneth, René E M Toes

Eur J Immunol· January 2025

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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study.
Shoichi Fukui, Tohru Michitsuji, Yushiro Endo, Ayako Nishino, Kaori Furukawa, René E M Toes

RMD Open· January 2025

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