Publications by authors named "Rhys M Jones"

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The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration.
Narayan Cheruvu, Esther van Duijn, Pieter A Spigt, Ioana M Barbu, Sima S Toussi, Rhys M Jones

Drug Metab Dispos· October 2023

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Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7.
Gary E Aspnes, Elnaz Menhaji-Klotz, Markus Boehm, Allyn T Londregan, Esther C Y Lee, Rhys M Jones

Bioorg Med Chem Lett· October 2021

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner

Nat Commun· October 2021

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Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner

bioRxiv· February 2021

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Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.
Elnaz Menhaji-Klotz, Kevin D Hesp, Allyn T Londregan, Amit S Kalgutkar, David W Piotrowski, Rhys M Jones

J Med Chem· April 2018

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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
Peter Jones, R Ian Storer, Yogesh A Sabnis, Florian M Wakenhut, Gavin A Whitlock, Rhys M Jones

J Med Chem· January 2017

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Effects of competition on the sleep patterns of elite rugby union players.
David A Shearer, Rhys M Jones, Liam P Kilduff, Christian J Cook

Eur J Sport Sci· September 2016

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Measuring Recovery in Elite Rugby Players: The Brief Assessment of Mood, Endocrine Changes, and Power.
David A Shearer, Liam P Kilduff, Charlotte Finn, Rhys M Jones, Richard M Bracken

Res Q Exerc Sport· August 2016

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Molecular hybridization yields triazole bronchodilators for the treatment of COPD.
Lyn H Jones, Jane Burrows, Neil Feeder, Paul Glossop, Kim James, Rhys M Jones

Bioorg Med Chem Lett· November 2015

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Relationship between repeated sprint ability and aerobic capacity in professional soccer players.
Rhys M Jones, Christian C Cook, Liam P Kilduff, Zoran Milanović, Nic James

ScientificWorldJournal· June 2014

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A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats.
Rhys M Jones, Anthony Harrison

Xenobiotica· January 2012

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Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity.
Rhys M Jones, Natasha Neef

Xenobiotica· January 2012

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Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Charles E Mowbray, Andrew S Bell, Nicholas P Clarke, Michelle Collins, Rhys M Jones

Bioorg Med Chem Lett· November 2011

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Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
M Abid Masood, Matthew D Selby, Andrew S Bell, Andrew C Mansfield, Mark Gardner, Rhys M Jones

Bioorg Med Chem Lett· November 2011

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Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
David S Millan, Stephen A Ballard, Sara Chunn, Joseph A Dybowski, Craig K Fulton, Rhys M Jones

Bioorg Med Chem Lett· October 2011

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Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.
Lyn H Jones, Helen Baldock, Mark E Bunnage, Jane Burrows, Nick Clarke, Rhys M Jones

Bioorg Med Chem Lett· May 2011

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An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Paul A Stupple, David V Batchelor, Martin Corless, Patrick K Dorr, David Ellis, Rhys M Jones

J Med Chem· January 2011

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Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.
Paul A Glossop, Charlotte A L Lane, David A Price, Mark E Bunnage, Russell A Lewthwaite, Rhys M Jones

J Med Chem· September 2010

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Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.
Simon J Mantell, Peter T Stephenson, Sandra M Monaghan, Graham N Maw, Michael A Trevethick, Rhys M Jones

Bioorg Med Chem Lett· February 2008

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The sulfonamide group as a structural alert: A distorted story?
Dennis A Smith, Rhys M Jones

Curr Opin Drug Discov Devel· January 2008

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