Publications by authors named "Richard Clements"

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Enhancing heart valve disease surveillance: a quality improvement project demonstrating cost-effective triaging and Clinical Scientist-led services to improve patient care.
Emily King, Richard Clements, Nathan Proudlove

Echo Res Pract· October 2025

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Pharmacological Enhancement of Small Conductance Ca-Activated K Channels Suppresses Cardiac Arrhythmias in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
Roland Veress, Radmila Terentyeva, Andriy E Belevych, Fruzsina Perger, Zuzana Nichtova, Richard T Clements

Circ Res· July 2025

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Integration of a specialist pharmacist-led multidisciplinary team in primary care: preventing strokes in people with atrial fibrillation across North East London.
Mital Patel, Jagjot Kaur Chahal, John Robson, Shabana Ali, Richard Clements

BMJ Open Qual· January 2025

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ML-GAP: machine learning-enhanced genomic analysis pipeline using autoencoders and data augmentation.
Melih Agraz, Dincer Goksuluk, Peng Zhang, Bum-Rak Choi, Richard T Clements

Front Genet· September 2024

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Reduced exercise capacity occurs before intrinsic skeletal muscle dysfunction in experimental rat models of pulmonary hypertension.
Peng Zhang, Denielli Da Silva Goncalves Bos, Alexander Vang, Julia Feord, Danielle J McCullough, Richard T Clements

Pulm Circ· April 2024

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Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction.
Wenzhuo Ma, Peng Zhang, Alexander Vang, Alexsandra Zimmer, Scarlett Huck, Richard T Clements

bioRxiv· March 2024

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Calpain inhibition decreases oxidative stress via mitochondrial regulation in a swine model of chronic myocardial ischemia.
Brittany A Potz, Sharif A Sabe, Laura A Scrimgeour, Ashraf A Sabe, Dwight D Harris, Richard T Clements

Free Radic Biol Med· November 2023

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Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes.
Richard T Clements, Radmila Terentyeva, Shanna Hamilton, Paul M L Janssen, Karim Roder

Basic Res Cardiol· May 2023

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Calpain inhibition decreases myocardial fibrosis in chronically ischemic hypercholesterolemic swine.
Brittany A Potz, Ashraf A Sabe, Sharif A Sabe, Isabella J Lawandy, M Ruhul Abid, Richard T Clements

J Thorac Cardiovasc Surg· January 2022

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MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca release in hypertrophic rat cardiomyocytes.
Shanna Hamilton, Radmila Terentyeva, Fruzsina Perger, Benjamín Hernández Orengo, Benjamin Martin, Richard T Clements

Am J Physiol Heart Circ Physiol· October 2021

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Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.
Shanna Hamilton, Radmila Terentyeva, Richard T Clements, Andriy E Belevych, Dmitry Terentyev

J Mol Cell Cardiol· July 2021

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α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension.
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R Morrison, Richard T Clements

JCI Insight· June 2021

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PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.
Shanna Hamilton, Iuliia Polina, Radmila Terentyeva, Peter Bronk, Tae Yun Kim, Richard T Clements

J Physiol· July 2020

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Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly.
Danielle J McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T Clements

Pulm Circ· May 2020

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Diabetes quality improvement at scale: how Barking and Dagenham, Redbridge, and Havering CCGs tackled the 'Seven Spreadly Sins'.
Anju Gupta, Ann Baldwin, Jyoti Sood, Richard Clements

Br J Gen Pract· January 2020

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Treatment of Pulmonary Hypertension With Angiotensin II Receptor Blocker and Neprilysin Inhibitor Sacubitril/Valsartan.
Richard T Clements, Alexander Vang, Ana Fernandez-Nicolas, Nouaying R Kue, Thomas J Mancini

Circ Heart Fail· November 2019

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Pharmacological Modulation of Mitochondrial Ca Content Regulates Sarcoplasmic Reticulum Ca Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species.
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T Clements

Front Physiol· December 2018

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Glycogen synthase kinase 3β inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia.
Brittany A Potz, Laura A Scrimgeour, Sharif A Sabe, Richard T Clements, Neel R Sodha

J Thorac Cardiovasc Surg· June 2018

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Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis.
Ayed M Allawzi, Alexander Vang, Richard T Clements, Bong Sook Jhun, Nouaying R Kue

Am J Respir Cell Mol Biol· May 2018

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Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes.
Bong Sook Jhun, Jin O-Uchi, Stephanie M Adaniya, Thomas J Mancini, Jessica L Cao, Richard T Clements

J Physiol· March 2018

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Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia.
Brittany A Potz, Ashraf A Sabe, Nassrene Y Elmadhun, Sharif A Sabe, Benedikt J V Braun, Richard T Clements

Surgery· May 2017

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Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.
Alexander Vang, Richard T Clements, Havovi Chichger, Nouaying Kue, Ayed Allawzi

Am J Physiol Lung Cell Mol Physiol· May 2017

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SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.
Tae Yun Kim, Radmila Terentyeva, Karim H F Roder, Weiyan Li, Man Liu, Richard T Clements

Cardiovasc Res· March 2017

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Calpain inhibition modulates glycogen synthase kinase 3β pathways in ischemic myocardium: A proteomic and mechanistic analysis.
Brittany A Potz, Ashraf A Sabe, Nassrene Y Elmadhun, Richard T Clements, M Ruhul Abid

J Thorac Cardiovasc Surg· February 2017

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Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome.
Brittany A Potz, Ashraf A Sabe, Nassrene Y Elmadhun, Richard T Clements, Michael P Robich

J Am Heart Assoc· July 2016

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