Publications by authors named "Richard D Unwin"

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Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease.
Jingshu Xu, Stefano Patassini, Paul Begley, Stephanie Church, Henry J Waldvogel, Richard L M Faull, Richard D Unwin, Garth J S Cooper

June 2020

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CTx001 for Geographic Atrophy: A Gene Therapy Expressing Soluble, Truncated Complement Receptor 1 (Mini-CR1).
Sonika Rathi, Athanasios Didangelos, Sofiya Pisarenka, Rachel Green, Stamatia Zafeiri, Richard D Unwin

Ophthalmol Sci· January 2026

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CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival.
Aseel Sharaireh, Marta Guevara-Ferrer, Anna M Ludlaim, Jonathan D Humphries, Alexander M Phillips, Richard D Unwin

Cell Death Dis· October 2025

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Cell Surface Proteomics Reveals Hypoxia-Regulated Pathways in Cervical and Bladder Cancer.
Faris Alanazi, Ammar Sharif, Melissa Kidd, Emma-Jayne Keevill, Vanesa Biolatti, Richard D Unwin

Proteomes· August 2025

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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration.
Christabel Thembela Dube, Hamish T J Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Richard D Unwin

Arthritis Res Ther· February 2025

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Intrinsic PARG inhibitor sensitivity is mimicked by haploinsufficiency and rescued by nucleoside supplementation.
Camilla Coulson-Gilmer, Samantha Littler, Bethany M Barnes, Rosie M Brady, Holda A Anagho, Richard D Unwin

NAR Cancer· September 2024

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Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial.
Subash Raj Susai, Melanie Föcking, David Mongan, Meike Heurich, Fiona Coutts, Richard D Unwin

Schizophr Bull· July 2023

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Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias.
Sasha A Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J Church, Richard D Unwin

Front Mol Neurosci· July 2023

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Development of a sensitive biochemical assay for the detection of tofacitinib adherence.
Stephanie Church, Kimme L Hyrich, Kayode Ogungbenro, Richard D Unwin, Anne Barton

Anal Methods· April 2023

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Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson's disease dementia brain.
Melissa Scholefield, Stephanie J Church, George Taylor, David Knight, Richard D Unwin

NPJ Parkinsons Dis· April 2023

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Elevated hippocampal copper in cases of type 2 diabetes.
Sasha A Philbert, Sarah J Schönberger, Jingshu Xu, Stephanie J Church, Richard D Unwin

EBioMedicine· December 2022

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Uncertainty-Aware Protein-Level Quantification and Differential Expression Analysis of Proteomics Data with seaMass.
Alexander M Phillips, Richard D Unwin, Simon J Hubbard, Andrew W Dowsey

Methods Mol Biol· November 2022

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Levels of soluble complement regulators predict severity of COVID-19 symptoms.
Anna L Tierney, Wajd Mohammed Alali, Thomas Scott, Karen S Rees-Unwin, , Richard D Unwin

Front Immunol· November 2022

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Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis.
Sasha A Philbert, Jingshu Xu, Stephanie J Church, Richard D Unwin, Federico Roncaroli

Front Aging Neurosci· July 2022

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Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer's Disease Consistent With Cerebral Pantothenate Deficiency.
Crystal Sang, Sasha A Philbert, Danielle Hartland, Richard D Unwin, Andrew W Dowsey

Front Aging Neurosci· June 2022

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Global Proteomic Profiling of Embryonic Stem Cells Using iTRAQ Isobaric Tags with LC-MS/MS Quantification.
Aseel Sharaireh, Anna L Tierney, Richard D Unwin

Methods Mol Biol· May 2022

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Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26.
Selina Mcharg, Laura Booth, Rahat Perveen, Isabel Riba Garcia, Nicole Brace, Richard D Unwin

Proc Natl Acad Sci U S A· May 2022

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Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization.
Izabela P Klaska, Anne White, Pilar Villacampa, Justin Hoke, Laura Abelleira-Hervas, Richard D Unwin

Exp Eye Res· February 2022

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A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.
Emily R Mears, Renee R Handley, Matthew J Grant, Suzanne J Reid, Benjamin T Day, Richard D Unwin

J Huntingtons Dis· January 2022

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Theranos's lesson for investors: speak to lab workers.
Richard D Unwin, Daniela S Couto, Simon J Clark

Nature· January 2022

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Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na/K-ATPase Dysfunction in Vascular Dementia.
Sasha A Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J Church, Richard D Unwin

Front Aging Neurosci· January 2022

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Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma.
Lijie Zhai, April Bell, Erik Ladomersky, Kristen L Lauing, Lakshmi Bollu, Richard D Unwin

Clin Cancer Res· December 2021

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Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis.
Hazal Haytural, Rui Benfeitas, Sophia Schedin-Weiss, Erika Bereczki, Melinda Rezeli, Richard D Unwin

Sci Data· December 2021

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Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia.
Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Richard D Unwin

Front Mol Neurosci· October 2021

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Adipocyte NR1D1 dictates adipose tissue expansion during obesity.
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Richard D Unwin

Elife· August 2021

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Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia.
Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Nigel M Hooper, Richard D Unwin

Metabolites· August 2021

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