June 2020 PMID 32416962

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease.

Jingshu Xu, Stefano Patassini, Paul Begley, Stephanie Church, Henry J Waldvogel, Richard L M Faull, Richard D Unwin, Garth J S Cooper

Mentions

12
Peak: 3 in Mar 2025
across 3 sources since May 2020

Extended reach

1,415,924
potential audience

Total likes

29,281

Video views

1,406,288

Mentions per month

May 2020 – Dec 2025

Where it's discussed

  • YouTube6 videos
  • X / Twitter4 posts
  • News2 articles

AI synopsis

What people are saying

Discussions demonstrate a balanced perspective, with posts like 'could this lead to new therapies?' reflecting curiosity and hope, while others like 'more evidence needed' show cautious appraisal. The tone shifts between optimistic and skeptical, emphasizing the perceived potential impact of this research on understanding and treating Alzheimer's disease.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with many supporting the idea that vitamin B5 deficiency could be a key factor in neurodegeneration and treatable in Alzheimer's.

InterestModerate interest

Participants show moderate curiosity, often mentioning potential for new treatments and the novelty of the findings, but some remain cautious or skeptical.

EngagementModerate engagement

The discussions include some detailed references to the study's methods and implications, suggesting a reasonable depth of engagement.

ImpactModerate impact

Many commentators believe this research could influence future approaches to dementia treatment, highlighting its possible clinical importance.

Abstract in brief

  • The study suggests that a deficiency of vitamin B5 (pantothenic acid) in the brain may be a contributing and potentially reversible factor in the neurodegeneration and dementia seen in Alzheimer's disease (AD), especially in brain regions that suffer severe damage.
  • Researchers measured vitamin B5 levels in different brain regions and found significant shortages, particularly in areas like the hippocampus and entorhinal cortex, which are crucial for memory and cognition.
  • Since vitamin B5 is essential for producing key molecules involved in brain function, such as neurotransmitters and myelin, supplementing with oral vitamin B5 could offer a new, safe option for preventing or reversing early stages of AD-related neurodegeneration.]

Top posts

Most liked on X and Bluesky
MetabolomicsBot
@MetabolomicsBot · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease https://t.co/iNC8jmgmJS

Jun 1, 2020 · 1 like · 925 followers View post →
BioMassSpec
@realBioMassSpec · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease #BBRC #MassSpec https://t.co/NdGlvBIbD3

May 18, 2020 · 5,995 followers View post →
Daughter of God
@PattyGodschild · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodege… https://t.co/VIb9XpHrPc

Mar 22, 2025 · 2,162 followers View post →
Jerry Dean Bowers
@vipertoxin · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease - PubMed https://t.co/Tlw3IZAxe3

Oct 1, 2023 · 558 followers View post →

All mentions

Daughter of God
@PattyGodschild · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodege… https://t.co/VIb9XpHrPc

Mar 22, 2025 · 2,162 followers View post →
Jerry Dean Bowers
@vipertoxin · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease - PubMed https://t.co/Tlw3IZAxe3

Oct 1, 2023 · 558 followers View post →
MetabolomicsBot
@MetabolomicsBot · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease https://t.co/iNC8jmgmJS

Jun 1, 2020 · 1 like · 925 followers View post →
BioMassSpec
@realBioMassSpec · X

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease #BBRC #MassSpec https://t.co/NdGlvBIbD3

May 18, 2020 · 5,995 followers View post →