Publications by authors named "Richard Engh"

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Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis.
Philip Rainsford, Fredrik G Rylandsholm, Martin Jakubec, Mitchell Silk, Eric Juskewitz, Richard A Engh

Sci Rep· August 2023

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Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics.
Robin Lorenz, Jian Wu, Friedrich W Herberg, Susan S Taylor, Richard A Engh

Biochemistry· November 2021

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Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome.
Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R Stasko, Ilya Bederman

Pharmaceuticals (Basel)· November 2021

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Inhibitor binding to mutants of protein kinase A with GGGxxG and GxGxxA glycine-rich loop motifs.
Kazi A Alam, Osman A S B M Gani, Richard A Engh

J Mol Recognit· April 2021

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Corrigendum: Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Birgit S Lauber, Leo A Hardegger, Kazi A Alam, Bjarte A Lund, Oliver Dumele, Richard A Engh

Chemistry· July 2020

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Two SnRK2-Interacting Calcium Sensor Isoforms Negatively Regulate SnRK2 Activity by Different Mechanisms.
Krzysztof Tarnowski, Maria Klimecka, Arkadiusz Ciesielski, Grażyna Goch, Anna Kulik, Richard A Engh

Plant Physiol· February 2020

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Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.
Anna Czarna, Jinhua Wang, Diana Zelencova, Yao Liu, Xianming Deng, Richard A Engh

J Med Chem· September 2018

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Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization.
Balmukund S Thakkar, John Sigurd M Svendsen, Richard A Engh

Molecules· September 2018

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Dynamical models of mutated chronic myelogenous leukemia cells for a post-imatinib treatment scenario: Response to dasatinib or nilotinib therapy.
Clemens Woywod, Franz X Gruber, Richard A Engh, Tor Flå

PLoS One· September 2017

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Cis/Trans Isomerization in Secondary Amides: Reaction Paths, Nitrogen Inversion, and Relevance to Peptidic Systems.
Balmukund S Thakkar, John-Sigurd M Svendsen, Richard A Engh

J Phys Chem A· September 2017

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Biofocussed chemoprospecting: An efficient approach for drug discovery.
Balmukund Sureshkumar Thakkar, Marte Albrigtsen, John Sigurd Svendsen, Jeanette H Andersen, Richard Alan Engh

Chem Biol Drug Des· July 2017

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Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.
Dilip Narayanan, Osman A B S M Gani, Franz X E Gruber, Richard A Engh

J Cheminform· July 2017

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Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules.
Ulli Rothweiler, Wenche Stensen, Bjørn Olav Brandsdal, Johan Isaksson, Frederick Alan Leeson, Richard Alan Engh

J Med Chem· November 2016

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Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Taavi Ivan, Erki Enkvist, Birgit Viira, Ganesh Babu Manoharan, Gerda Raidaru, Richard Alan Engh

Bioconjug Chem· August 2016

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Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Birgit S Lauber, Leo A Hardegger, Kazi A Alam, Bjarte A Lund, Oliver Dumele, Richard A Engh

Chemistry· January 2016

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Perspective on computational and structural aspects of kinase discovery from IPK2014.
Eric Martin, Stefan Knapp, Richard A Engh, Henrik Moebitz, Thibault Varin

Biochim Biophys Acta· October 2015

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Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches.
Osman A Gani, Balmukund Thakkar, Dilip Narayanan, Kazi A Alam, Peter Kyomuhendo, Richard A Engh

Biochim Biophys Acta· October 2015

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Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells.
Anna L Illert, Anna K Seitz, Christoph Rummelt, Stefanie Kreutmair, Richard A Engh

PLoS One· July 2015

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The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
Marina Alexeeva, Espen Åberg, Richard A Engh, Ulli Rothweiler

Acta Crystallogr D Biol Crystallogr· May 2015

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Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors.
Ulli Rothweiler, Jonas Eriksson, Wenche Stensen, Frederick Leeson, Richard A Engh

Eur J Med Chem· April 2015

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Evaluating the predictivity of virtual screening for ABL kinase inhibitors to hinder drug resistance.
Osman A B S M Gani, Dilip Narayanan, Richard A Engh

Chem Biol Drug Des· November 2013

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Antitumoral and mechanistic studies of ianthelline isolated from the Arctic sponge Stryphnus fortis.
Kine Ø Hanssen, Jeanette H Andersen, Trine Stiberg, Richard A Engh, Johan Svenson

Anticancer Res· October 2012

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Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool.
Espen Åberg, Bjarte Lund, Alexander Pflug, Osman A B S M Gani, Ulli Rothweiler, Richard A Engh

Biol Chem· October 2012

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Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89.
Alexander Pflug, Kenneth A Johnson, Richard A Engh

Acta Crystallogr Sect F Struct Biol Cryst Commun· August 2012

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Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib.
Rama Krishna Kancha, Nikolas von Bubnoff, Natalie Bartosch, Christian Peschel, Richard A Engh

PLoS One· March 2012

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