Publications by authors named "Alexander Pflug"

Claim this Profile
D
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
Avipsa Ghosh, Afshan Ahmed, Konstantina Amoiradaki, Amber Y S Balazs, Bernard Barlaam, Alexander Pflug

J Med Chem· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.
Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, Robert Casella, Steve Cook, Alexander Pflug

RSC Med Chem· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Jason D Shields, David Baker, Amber Y S Balazs, Gayathri Bommakanti, Robert Casella, Alexander Pflug

J Med Chem· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Causes of Death in the Seriously Injured -Why do Severely Injured Patients Die Today?
Arne Wilharm, Alexander Pflug, Franz Loos, Oliver Sommerfeld, Gunther O Hofmann

Z Orthop Unfall· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction: Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug

PLoS Pathog· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex.
Lucy V Edwardes, Sarah J Caswell, Mariacarmela Giurrandino, Xiang Zhai, Andrea Gohlke, Alexander Pflug

Biochemistry· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug

PLoS Pathog· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A computed tomography based survey study investigating the agreement of the therapeutic strategy for fragility fractures of the pelvis.
Philipp Pieroh, Tim Hohmann, Florian Gras, Sven Märdian, Alexander Pflug

Sci Rep· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of an Imidazo[1,2-]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with Efficacy.
William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood, Alexander Pflug

J Med Chem· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A Clark, Olga Collingwood, Alexander Pflug

J Med Chem· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.
Alexander Pflug, Marianne Schimpl, J Willem M Nissink, Ross C Overman, Philip B Rawlins

Biochem J· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Joanna M Wandzik, Tomas Kouba, Manikandan Karuppasamy, Alexander Pflug, Petra Drncova

Cell· May 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fragility Fractures of the Pelvis Classification: A Multicenter Assessment of the Intra-Rater and Inter-Rater Reliabilities and Percentage of Agreement.
Philipp Pieroh, Andreas Höch, Tim Hohmann, Florian Gras, Sven Märdian, Alexander Pflug

J Bone Joint Surg Am· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Alexander Pflug, Stephanie Gaudon, Patricia Resa-Infante, Mathilde Lethier, Stefan Reich

Nucleic Acids Res· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural insights into RNA synthesis by the influenza virus transcription-replication machine.
Alexander Pflug, Maria Lukarska, Patricia Resa-Infante, Stefan Reich, Stephen Cusack

Virus Res· April 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Maria Lukarska, Guillaume Fournier, Alexander Pflug, Patricia Resa-Infante, Stefan Reich

Nature· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Taavi Ivan, Erki Enkvist, Birgit Viira, Ganesh Babu Manoharan, Gerda Raidaru, Alexander Pflug

Bioconjug Chem· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
Eric Thierry, Delphine Guilligay, Jan Kosinski, Thomas Bock, Stephanie Gaudon, Alexander Pflug

Mol Cell· January 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure of influenza A polymerase bound to the viral RNA promoter.
Alexander Pflug, Delphine Guilligay, Stefan Reich, Stephen Cusack

Nature· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Stefan Reich, Delphine Guilligay, Alexander Pflug, Hélène Malet, Imre Berger

Nature· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.
Tommaso Tosi, Alexander Pflug, Karen F Discola, David Neves, Andréa Dessen

Res Microbiol· January 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool.
Espen Åberg, Bjarte Lund, Alexander Pflug, Osman A B S M Gani, Ulli Rothweiler

Biol Chem· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89.
Alexander Pflug, Kenneth A Johnson, Richard A Engh

Acta Crystallogr Sect F Struct Biol Cryst Commun· August 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase.
Alexander Pflug, Taianá Maia de Oliveira, Dirk Bossemeyer, Richard A Engh

Biochem J· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
Alexander Pflug, Jevgenia Rogozina, Darja Lavogina, Erki Enkvist, Asko Uri

J Mol Biol· October 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis