Publications by authors named "Matthew A Clark"

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A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library.
Marcos E Milla, Jonathan M Blevitt, Steven D Goldberg, Anthony A Armstrong, Katherine Y Blain, Matthew A Clark

ACS Med Chem Lett· November 2025

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Multiclass Synthetic Accessibility Prediction.
Xinqi Li, Ryan Walsh, Waseem Abbas, Sergio Pascual-Diaz, Calum Hand, Matthew A Clark

J Chem Inf Model· February 2025

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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.
Suzanne Ackloo, Fengling Li, Magda Szewczyk, Almagul Seitova, Peter Loppnau, Matthew A Clark

J Med Chem· January 2025

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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants.
Xu Wang, Dimitar Gotchev, Kristi Yi Fan, Marvin M Vega, Nagraj Mani, Matthew A Clark

J Med Chem· November 2024

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Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
Koen F W Hekking, Sergio Maroto, Kees van Kekem, Frank S Haasjes, Jack C Slootweg, Matthew A Clark

J Med Chem· February 2024

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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.
Gavin W Collie, Matthew A Clark, Anthony D Keefe, Andrew Madin, Jon A Read

J Med Chem· January 2024

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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
Shabbir Ahmad, Jin Xu, Jianwen A Feng, Ashley Hutchinson, Hong Zeng, Matthew A Clark

J Med Chem· December 2023

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Discovery of Novel UDP--Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against .
M Dominic Ryan, Alastair L Parkes, David Corbett, Anthony P Dickie, Michelle Southey, Matthew A Clark

J Med Chem· October 2021

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Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).
Yun Ding, Svetlana Belyanskaya, Jennifer L DeLorey, Jeffrey A Messer, G Joseph Franklin, Matthew A Clark

Bioorg Med Chem· July 2021

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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.
John P Guilinger, Archna Archna, Martin Augustin, Andreas Bergmann, Paolo A Centrella, Matthew A Clark

Bioorg Med Chem· July 2021

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Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
Esther C Y Lee, Andrew J McRiner, Katy E Georgiadis, Julie Liu, Zooey Wang, Matthew A Clark

J Med Chem· May 2021

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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.
Jeremy S Disch, Jennifer M Duffy, Esther C Y Lee, Diana Gikunju, Betty Chan, Matthew A Clark

J Med Chem· April 2021

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Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A Clark, Olga Collingwood

J Med Chem· March 2021

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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.
Kevin McCloskey, Eric A Sigel, Steven Kearnes, Ling Xue, Xia Tian, Matthew A Clark

J Med Chem· August 2020

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Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.
Ji Young Kim, Laura A Jayne, Yuntao Bai, Mei Ji He Ho Feng, Matthew A Clark

Biochem Pharmacol· July 2020

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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.
John W Cuozzo, Matthew A Clark, Anthony D Keefe, Anna Kohlmann, Mark Mulvihill

J Med Chem· July 2020

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Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry.
Alexander Litovchick, Xia Tian, Michael I Monteiro, Kaitlyn M Kennedy, Marie-Aude Guié, Matthew A Clark

Molecules· May 2019

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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
Dean G Brown, Giles A Brown, Paolo Centrella, Kaan Certel, Robert M Cooke, Matthew A Clark

SLAS Discov· June 2018

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Development and Synthesis of DNA-Encoded Benzimidazole Library.
Yun Ding, Jing Chai, Paolo A Centrella, Chenaimwoyo Gondo, Jennifer L DeLorey, Matthew A Clark

ACS Comb Sci· May 2018

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Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library.
John W Cuozzo, Paolo A Centrella, Diana Gikunju, Sevan Habeshian, Christopher D Hupp, Matthew A Clark

Chembiochem· December 2017

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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.
Amaury E Fernández-Montalván, Markus Berger, Benno Kuropka, Seong Joo Koo, Volker Badock, Matthew A Clark

ACS Chem Biol· November 2017

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Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".
Jeffrey W Johannes, Stephanie Bates, Carl Beigie, Matthew A Belmonte, John Breen, Matthew A Clark

ACS Med Chem Lett· November 2017

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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.
John W Cuozzo, Paolo A Centrella, Diana Gikunju, Sevan Habeshian, Christopher D Hupp, Matthew A Clark

Chembiochem· May 2017

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Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
Jeffrey W Johannes, Stephanie Bates, Carl Beigie, Matthew A Belmonte, John Breen, Matthew A Clark

ACS Med Chem Lett· February 2017

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Holly H Soutter, Paolo Centrella, Matthew A Clark, John W Cuozzo, Christoph E Dumelin

Proc Natl Acad Sci U S A· December 2016

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