Publications by authors named "Jon A Read"

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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.
Gavin W Collie, Matthew A Clark, Anthony D Keefe, Andrew Madin, Jon A Read

J Med Chem· January 2024

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sharan K Bagal, Clare Gregson, Daniel H O' Donovan, Kurt G Pike, Andrew Bloecher, Jon A Read

J Med Chem· December 2021

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Discovery of (2)--[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
Qibin Su, Erica Banks, Geraldine Bebernitz, Kirsten Bell, Cassandra F Borenstein, Jon A Read

J Med Chem· May 2020

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Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Jon A Read, Jonathan Tart, Philip B Rawlins, Clare Gregson, Karen Jones

ACS Chem Biol· October 2019

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AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Alice E Pollard, Luís Martins, Phillip J Muckett, Sanjay Khadayate, Aurélie Bornot, Jon A Read

Nat Metab· March 2019

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Jon A Read

J Med Chem· June 2018

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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Bin Yang, Melissa M Vasbinder, Alexander W Hird, Qibin Su, Haixia Wang, Jon A Read

J Med Chem· February 2018

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X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Michael R Witten, Lisa Wissler, Melanie Snow, Stefan Geschwindner, Jon A Read

J Med Chem· November 2017

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Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease.
Fernando Orden Rueda, Michal Bista, Matthew D Newton, Anne U Goeppert, M Emanuela Cuomo, Jon A Read

Nat Commun· November 2017

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Holly H Soutter, Paolo Centrella, Matthew A Clark, John W Cuozzo, Christoph E Dumelin, Jon A Read

Proc Natl Acad Sci U S A· December 2016

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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Anna A Marusiak, Natalie L Stephenson, Hayeon Baik, Eleanor W Trotter, Yaoyong Li, Jon A Read

Cancer Res· February 2016

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Jeffrey W Johannes, Lynsie Almeida, Kevin Daly, Andrew D Ferguson, Shaun E Grosskurth, Jon A Read

Bioorg Med Chem Lett· December 2015

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Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Ruben C Hartkoorn, Florence Pojer, Jon A Read, Helen Gingell, João Neres

Nat Chem Biol· February 2014

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Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.
Qibin Su, Stephanos Ioannidis, Claudio Chuaqui, Lynsie Almeida, Marat Alimzhanov, Jon A Read

J Med Chem· January 2014

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Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.
Pravin S Shirude, Prashanti Madhavapeddi, Maruti Naik, Kannan Murugan, Vikas Shinde, Jon A Read

J Med Chem· November 2013

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