Publications by authors named "Richard Lake"

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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.
Wee Loong Chin, Alistair M Cook, Jonathan Chee, Nicola Principe, Tracy S Hoang, Richard A Lake

Cell Rep Med· January 2025

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Mesothelioma survival prediction based on a six-gene transcriptomic signature.
Kiarash Behrouzfar, Steve E Mutsaers, Wee Loong Chin, Kimberley Patrick, Isaac Trinstern Ng, Richard A Lake

iScience· October 2024

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Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy.
Wee Loong Chin, Rachael M Zemek, Caitlin M Tilsed, Alistair R R Forrest, Vanessa S Fear, Richard A Lake

Sci Data· May 2024

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Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes.
Joel Kidman, Rachael M Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Richard A Lake

Oncoimmunology· April 2024

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The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop.
Scott A Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Richard A Lake

Front Toxicol· April 2024

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Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner.
Caitlin M Tilsed, M Lizeth Orozco Morales, Rachael M Zemek, Brianna A Gordon, Matthew J Piggott, Richard A Lake

BMC Cancer· February 2024

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Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.
M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Y C Gary Lee, Richard A Lake

PLoS One· May 2023

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CD4 T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy.
Caitlin M Tilsed, Nicola Principe, Joel Kidman, Wee Loong Chin, M Lizeth Orozco Morales, Richard A Lake

Cell Rep· December 2022

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Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice.
Rachael M Zemek, Wee Loong Chin, Vanessa S Fear, Ben Wylie, Thomas H Casey, Richard A Lake

Nat Commun· August 2022

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Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action.
Caitlin M Tilsed, Scott A Fisher, Anna K Nowak, Richard A Lake, W Joost Lesterhuis

Front Oncol· July 2022

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Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations.
Nicola Principe, Wayne J Aston, Danika E Hope, Caitlin M Tilsed, Scott A Fisher, Richard A Lake

Front Immunol· June 2022

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Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy.
Caitlin M Tilsed, Thomas H Casey, Emma de Jong, Anthony Bosco, Rachael M Zemek, Richard A Lake

Front Oncol· March 2022

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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Joel P A Gummer, Richard A Lake

iScience· January 2022

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Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used.
Vanessa S Fear, Catherine A Forbes, Samuel A Neeve, Scott A Fisher, Jonathan Chee, Richard Lake

Cancer Immunol Immunother· November 2021

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Correction to: Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used.
Vanessa S Fear, Catherine A Forbes, Samuel A Neeve, Scott A Fisher, Jonathan Chee, Richard Lake

Cancer Immunol Immunother· November 2021

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Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses.
Joel Kidman, Nicola Principe, Mark Watson, Timo Lassmann, Robert A Holt, Richard A Lake

Front Immunol· June 2021

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Tumor Infiltrating Effector Memory Antigen-Specific CD8 T Cells Predict Response to Immune Checkpoint Therapy.
Nicola Principe, Joel Kidman, Siting Goh, Caitlin M Tilsed, Scott A Fisher, Richard A Lake

Front Immunol· June 2021

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How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers.
Kiarash Behrouzfar, Kimberley Burton, Steve E Mutsaers, Grant Morahan, Richard A Lake

Front Oncol· June 2021

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A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers.
Alistair M Cook, Alison McDonnell, Michael J Millward, Jenette Creaney, Arman Hasani, Richard A Lake

Expert Rev Anticancer Ther· May 2021

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Malignant Pleural Effusions-A Window Into Local Anti-Tumor T Cell Immunity?
Nicola Principe, Joel Kidman, Richard A Lake, Willem Joost Lesterhuis, Anna K Nowak

Front Oncol· April 2021

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Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy.
Rachael M Zemek, Wee Loong Chin, Anna K Nowak, Michael J Millward, Richard A Lake

Front Immunol· March 2021

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Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model.
Scott A Fisher, Carolyn J Peddle-McIntyre, Kimberley Burton, Robert U Newton, Elly Marcq, Richard A Lake

BMC Res Notes· September 2020

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Bilateral murine tumor models for characterizing the response to immune checkpoint blockade.
Rachael M Zemek, Vanessa S Fear, Cath Forbes, Emma de Jong, Thomas H Casey, Richard A Lake

Nat Protoc· May 2020

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Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment.
Rachael M Zemek, Emma De Jong, Wee Loong Chin, Iona S Schuster, Vanessa S Fear, Richard A Lake

Sci Transl Med· July 2019

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Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment.
Wayne J Aston, Danika E Hope, Alistair M Cook, Louis Boon, Ian Dick, Richard A Lake

Oncoimmunology· July 2019

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