Publications by authors named "Richard Liggins"

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Evaluating the effectiveness of a novel somatostatin receptor 2 antagonist, ZT-01, for hypoglycemia prevention in a rodent model of type 2 diabetes.
Ninoschka C D'Souza, Julian A Aiken, Emily G Hoffman, Sara C Atherley, Sabrina Champsi, Richard L Liggins

Front Pharmacol· February 2024

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Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes.
Emily G Hoffman, Ninoschka C D'Souza, Richard T Liggins, Michael C Riddell

Front Pharmacol· January 2024

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Pharmacokinetics of small hyperbranched polyglycerols as an osmotic agent for peritoneal dialysis: Plasma exposure, organ distribution and excretion in rats.
Caigan Du, Roxana Jayo, Asher A Mendelson, Irina Chafeeva, Gerald da Roza, Richard Liggins

Perit Dial Int· July 2023

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Effects of somatostatin receptor type 2 antagonism during insulin-induced hypoglycaemia in male rats with prediabetes.
Emily G Hoffman, Ninoschka C D'Souza, Julian Aiken, Sara Atherley, Richard Liggins

Diabetes Obes Metab· June 2023

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ZT-01: A novel somatostatin receptor 2 antagonist for restoring the glucagon response to hypoglycaemia in type 1 diabetes.
Rawad Farhat, Julian Aiken, Ninoschka C D'Souza, Daniel Appadurai, Grayson Hull, Richard T Liggins

Diabetes Obes Metab· May 2022

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Somatostatin Receptor Antagonism Reverses Glucagon Counterregulatory Failure in Recurrently Hypoglycemic Male Rats.
Emily G Hoffman, Mahsa Jahangiriesmaili, Erin R Mandel, Caylee Greenberg, Julian Aiken, Richard Liggins

Endocrinology· December 2021

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Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self-propelling particles.
James R Baylis, Michael M Lee, Alexander E St John, Xu Wang, Eric Simonson, Richard T Liggins

J Thromb Haemost· October 2019

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Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution.
Bin Liu, Shijian Feng, Ghida Dairi, Qiunong Guan, Irina Chafeeva, Richard Liggins

BMC Nephrol· May 2019

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Enhanced taxane uptake into bladder tissues following co-administration with either mitomycin C, doxorubicin or gemcitabine: association to exfoliation processes.
Rakhi Pandey, John K Jackson, Richard Liggins, Clement Mugabe, Helen M Burt

BJU Int· November 2018

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Peritoneal and Systemic Responses of Obese Type II Diabetic Rats to Chronic Exposure to a Hyperbranched Polyglycerol-Based Dialysis Solution.
Bo La Han, Qiunong Guan, Irina Chafeeva, Asher A Mendelson, Gerald da Roza, Richard Liggins

Basic Clin Pharmacol Toxicol· October 2018

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Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.
Yue Shen, Matthew R Zeglinski, Christopher T Turner, Sheetal A Raithatha, Zhenguo Wu, Richard Liggins

Exp Mol Med· May 2018

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Self-Propelled Dressings Containing Thrombin and Tranexamic Acid Improve Short-Term Survival in a Swine Model of Lethal Junctional Hemorrhage.
James R Baylis, Alexander E St John, Xu Wang, Esther B Lim, Matthew L Statz, Richard T Liggins

Shock· September 2016

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Glucagon responses to exercise-induced hypoglycaemia are improved by somatostatin receptor type 2 antagonism in a rat model of diabetes.
Erwan Leclair, Richard T Liggins, Ashley J Peckett, Trevor Teich, David H Coy

Diabetologia· August 2016

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Tissue Permeability Effects Associated with the Use of Mucoadhesive Cationic Nanoformulations of Docetaxel in the Bladder.
Rakhi Pandey, John K Jackson, Clement Mugabe, Richard Liggins, Helen M Burt

Pharm Res· August 2016

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Corrigendum to "Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay" [Bioorg. Med. Chem. Lett. 25 (2015) 2505-2509].
Steve Arns, Jason Tan, Sharon Sun, Adam Galey, Natalia Zisman, Richard Liggins

Bioorg Med Chem Lett· July 2016

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Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir.
S-H Sheldon Tai, Olga Agafitei, Zhizeng Gao, Richard Liggins, Martin Petric

Virus Res· December 2015

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Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay.
Steve Arns, Jason Tan, Sharon Sun, Adam Galey, Natalia Zisman, Richard Liggins

Bioorg Med Chem Lett· June 2015

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Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.
Jin-Hyo Kim, Ricardo Resende, Tom Wennekes, Hong-Ming Chen, Nicole Bance, Richard Liggins

Science· April 2013

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Tissue uptake of docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols and their effects on the morphology of the bladder urothelium.
Clement Mugabe, Peter A Raven, Ladan Fazli, Jennifer H E Baker, John K Jackson, Richard T Liggins

Biomaterials· January 2012

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In vivo evaluation of mucoadhesive nanoparticulate docetaxel for intravesical treatment of non-muscle-invasive bladder cancer.
Clement Mugabe, Yoshiyuki Matsui, Alan I So, Martin E Gleave, Jennifer H E Baker, Richard Liggins

Clin Cancer Res· May 2011

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Synthesis and characterization of carboxylic acid conjugated, hydrophobically derivatized, hyperbranched polyglycerols as nanoparticulate drug carriers for cisplatin.
Lucy Ye, Kevin Letchford, Markus Heller, Richard Liggins, Dechi Guan

Biomacromolecules· January 2011

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In vitro human plasma distribution of nanoparticulate paclitaxel is dependent on the physicochemical properties of poly(ethylene glycol)-block-poly(caprolactone) nanoparticles.
Kevin Letchford, Richard Liggins, Kishor M Wasan, Helen Burt

Eur J Pharm Biopharm· February 2009

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Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)-block-polycaprolactone diblock copolymer micelles: theoretical and experimental data and correlations.
Kevin Letchford, Richard Liggins, Helen Burt

J Pharm Sci· March 2008

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Paclitaxel-loaded poly(L-lactic acid) microspheres 3: blending low and high molecular weight polymers to control morphology and drug release.
Richard T Liggins, Helen M Burt

Int J Pharm· September 2004

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Paclitaxel loaded poly(L-lactic acid) (PLLA) microspheres. II. The effect of processing parameters on microsphere morphology and drug release kinetics.
Richard T Liggins, Helen M Burt

Int J Pharm· August 2004

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