Publications by authors named "Richard Ludwig"

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Navigating atypical equilibrium dynamics of protein aggregates for biopharmaceutical release and stability monitoring.
Yiting Zhang, Ruojia Li, Hangtian Song, Andrew McClain, Richard Ludwig

J Chromatogr B Analyt Technol Biomed Life Sci· December 2025

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Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.
Andrew McClain, Yiting Zhang, Yan Yin, Qi Wang, Lih-Yueh Hwang, Richard Ludwig

Anal Chem· December 2022

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Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Richard Ludwig

J Am Soc Mass Spectrom· September 2022

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New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Richard Ludwig

J Am Soc Mass Spectrom· April 2021

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Enhancing Host-Cell Protein Detection in Protein Therapeutics Using HILIC Enrichment and Proteomic Analysis.
Qingyi Wang, Thomas R Slaney, Wei Wu, Richard Ludwig, Li Tao

Anal Chem· August 2020

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Structure-Function Assessment and High-Throughput Quantification of Site-Specific Aspartate Isomerization in Monoclonal Antibody Using a Novel Analytical Tool Kit.
Kaimeng Zhou, Xiang Cao, James Bautista, Zhi Chen, Neil Hershey, Richard Ludwig

J Pharm Sci· January 2020

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Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies.
Peiran Liu, Xin Zhu, Wei Wu, Richard Ludwig, Hangtian Song

Rapid Commun Mass Spectrom· January 2019

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Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance.
Tyler Hageman, Hui Wei, Patrick Kuehne, Jinmei Fu, Richard Ludwig

Pharm Res· December 2018

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Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins.
Gregory V Barnett, Gurusamy Balakrishnan, Naresh Chennamsetty, Brent Meengs, Jeffery Meyer, Richard Ludwig

J Pharm Sci· October 2018

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Early identification of unusually clustered mutations and root causes in therapeutic antibody development.
Yueming Qian, Zhiqiang Chen, Xin Huang, Xuning Wang, Xuankuo Xu, Richard Ludwig

Biotechnol Bioeng· September 2018

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Vitamin B association with mAbs: Mechanism and potential mitigation strategies.
Cheng Du, Robert Martin, Yunping Huang, Ameya Borwankar, Zhijun Tan, Richard Ludwig

Biotechnol Bioeng· April 2018

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Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process.
Cheng Du, Yunping Huang, Ameya Borwankar, Zhijun Tan, Anthony Cura, Richard Ludwig

MAbs· April 2018

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Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.
Tao Jiang, Hangtian Song, Thomas R Slaney, Wei Wu, Erik Langsdorf, Richard Ludwig

Anal Chem· December 2017

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Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.
Yuetian Yan, Hui Wei, Sutjano Jusuf, Stanley R Krystek, Jie Chen, Richard T Ludwig

J Pharm Sci· November 2017

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Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.
Yunping Huang, Jinmei Fu, Richard Ludwig, Li Tao, Jacob Bongers

J Chromatogr B Analyt Technol Biomed Life Sci· November 2017

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Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities.
Hangtian Song, Jianlin Xu, Mi Jin, Chao Huang, Jacob Bongers, Richard Ludwig

Pharm Res· April 2016

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Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.
Yuetian Yan, Hui Wei, Ya Fu, Sutjano Jusuf, Ming Zeng, Richard Ludwig

Anal Chem· February 2016

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Characterization and identification of alanine to serine sequence variants in an IgG4 monoclonal antibody produced in mammalian cell lines.
Jinmei Fu, Jacob Bongers, Li Tao, Dan Huang, Richard Ludwig

J Chromatogr B Analyt Technol Biomed Life Sci· November 2012

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Glycine to glutamic acid misincorporation observed in a recombinant protein expressed by Escherichia coli cells.
Yunping Huang, Brian O'Mara, Matthew Conover, Richard Ludwig, Jinmei Fu

Protein Sci· May 2012

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Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping.
Jacob Bongers, John Devincentis, Jinmei Fu, Peiqing Huang, David H Kirkley, Richard Ludwig

J Chromatogr A· November 2011

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