Publications by authors named "Richard Pearse"

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POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population.
Courtney R Benoit, Lilia B Sattler, Aimee J Aylward, Olivia Pembridge, Bella Kim, Richard V Pearse, Tracy L Young-Pearse

Brain· December 2025

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Augmented Tendon Repair with Internal Bracing: Surgical Technique.
Nina Handzewniak, Richard Pearse, Abbie Randall, Abid Mahmood, Tanvir Khan

J Clin Med· November 2025

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Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease.
Hyo Lee, Richard V Pearse, Alexandra M Lish, Cheryl Pan, Zachary M Augur, Tracy L Young-Pearse

Glia· June 2025

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CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density.
Alexandra M Lish, Elyssa F L Grogan, Courtney R Benoit, Richard V Pearse, Sarah E Heuer, Tracy L Young-Pearse

Neuron· June 2025

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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures.
Alexandra M Lish, Nancy Ashour, Richard V Pearse, Paige C Galle, Gwendolyn A Orme, Tracy L Young-Pearse

Cell Rep· June 2025

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A proteogenomic tool uncovers protein markers for human microglial states.
Verena Haage, Alex R Bautista, John Tuddenham, Victoria Marshe, Rebecca Chiu, Richard Pearse, Tracy L Young-Pearse

bioRxiv· April 2025

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Use of Internal Bracing in Multi-ligamentous Knee Injury Reconstruction: A Systematic Review.
Abbie Randall, Richard Pearse, Shahnawaz Khan, Henry Atkinson

Indian J Orthop· November 2024

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Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease.
Hyo Lee, Richard V Pearse, Alexandra M Lish, Cheryl Pan, Zachary M Augur, Tracy L Young-Pearse

bioRxiv· July 2024

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Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons.
Yi-Chen Hsieh, Zachary M Augur, Mason Arbery, Nancy Ashour, Katharine Barrett, Richard V Pearse, Tracy L Young-Pearse

Alzheimers Dement· April 2024

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Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.
Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Richard V Pearse, Tracy Young-Pearse

Nat Genet· April 2024

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INPP5D regulates inflammasome activation in human microglia.
Vicky Chou, Richard V Pearse, Aimee J Aylward, Nancy Ashour, Mariko Taga, Tracy L Young-Pearse

Nat Commun· November 2023

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Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1.
Hyo Lee, Aimee J Aylward, Richard V Pearse, Alexandra M Lish, Yi-Chen Hsieh, Tracy L Young-Pearse

Cell Rep· August 2023

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Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease.
Julie P Merchant, Kuixi Zhu, Marc Y R Henrion, Syed S A Zaidi, Branden Lau, Richard V Pearse, Tracy L Young-Pearse

Commun Biol· May 2023

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INPP5D/SHIP1 regulates inflammasome activation in human microglia.
Vicky Chou, Seeley B Fancher, Richard V Pearse, Hyo Lee, Matti Lam, Tracy L Young-Pearse

bioRxiv· February 2023

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Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1.
Hyo Lee, Aimee J Aylward, Richard V Pearse, Yi-Chen Hsieh, Zachary M Augur, Tracy L Young-Pearse

bioRxiv· February 2023

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Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study.
Lei Yu, Yi-Chen Hsieh, Richard V Pearse, Yanling Wang, Vladislav A Petyuk, Tracy L Young-Pearse

Neurology· November 2022

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RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
Robert J van der Linden, Jacqueline S Gerritsen, Meichen Liao, Joanna Widomska, Richard V Pearse, Tracy L Young-Pearse

Prog Neurobiol· October 2022

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Mosaic loss of Chromosome Y in aged human microglia.
Michael C Vermeulen, Richard Pearse, Tracy Young-Pearse, Sara Mostafavi

Genome Res· October 2022

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Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity.
Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V Pearse, Lei Liu, Tracy L Young-Pearse

Mol Neurodegener· September 2022

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APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.
Chun-I Wu, Elizabeth A Vinton, Richard V Pearse, Keunjung Heo, Aimee J Aylward, Tracy L Young-Pearse

Mol Psychiatry· April 2022

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Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Valentina N Lagomarsino, Richard V Pearse, Lei Liu, Yi-Chen Hsieh, Marty A Fernandez, Tracy L Young-Pearse

Neuron· November 2021

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Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system.
Richard V Pearse, Tracy L Young-Pearse

Brain Res· November 2019

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Somatic mosaicism of sex chromosomes in the blood and brain.
Emma J Graham, Michael Vermeulen, Badri Vardarajan, David Bennett, Phil De Jager, Richard V Pearse, Tracy L Young-Pearse

Brain Res· October 2019

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Drug-induced paraspinal myositis mimicking acute bilateral sciatica.
Richard Pearse, Ravindran Visagan, Kiran Reddy, Shumontha Dev

BMJ Case Rep· February 2019

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Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
Priya Srikanth, Valentina N Lagomarsino, Richard V Pearse, Meichen Liao, Sulagna Ghosh, Tracy L Young-Pearse

Transl Psychiatry· November 2018

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