Publications by authors named "Rick Cousins"

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Discovery and Characterization of SPL028: Deuterated ,-Dimethyltryptamine.
Marie Layzell, Peter Rands, Meghan Good, Zelah Joel, Rick Cousins

ACS Med Chem Lett· September 2023

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Hearing loss drug discovery and medicinal chemistry: Current status, challenges, and opportunities.
Rick Cousins

Prog Med Chem· June 2022

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The global hearing therapeutic pipeline: 2021.
Beverley Isherwood, Ana Cláudia Gonçalves, Rick Cousins, Ralph Holme

Drug Discov Today· March 2022

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Pharmacological validation of targets regulating CD14 during macrophage differentiation.
Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Rick Cousins

EBioMedicine· November 2020

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Medicines discovery for auditory disorders: Challenges for industry.
Rick P C Cousins

J Acoust Soc Am· November 2019

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Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.
Xin Zeng, Robert Kirkpatrick, Glenn Hofmann, Didier Grillot, Valerie Linhart, Rick Cousins

PLoS One· April 2019

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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.
Jeffrey K Kerns, Jakob Busch-Petersen, Wei Fu, Jeffrey C Boehm, Hong Nie, Rick Cousins

ACS Med Chem Lett· December 2018

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
John Liddle, Paul Bamborough, Michael D Barker, Sebastien Campos, Chun-Wa Chung, Rick P C Cousins

Bioorg Med Chem Lett· August 2012

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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
John Liddle, Paul Bamborough, Michael D Barker, Sebastien Campos, Rick P C Cousins

Bioorg Med Chem Lett· May 2009

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Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity.
Nicola Bevan, Peter R Butchers, Rick Cousins, Jill Coates, Emma V Edgar

Eur J Pharmacol· June 2007

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Enantioselective partial reduction of 2,5-disubstituted pyrroles via a chiral protonation approach.
Timothy J Donohoe, Graeme C Freestone, Catherine E Headley, Caroline L Rigby, Rick P C Cousins

Org Lett· September 2004

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Rearrangement of pyrrolines derived from the Birch reduction of electron-deficient pyrroles: radical ring-expansion to substituted tetrahydropyridines.
Peter G Turner, Timothy J Donohoe, Rick P C Cousins

Chem Commun (Camb)· June 2004

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Flexibility in the partial reduction of 2,5-disubstituted pyrroles: application to the synthesis of DMDP.
Timothy J Donohoe, Catherine E Headley, Rick P C Cousins, Andrew Cowley

Org Lett· April 2003

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