Publications by authors named "Rick Havinga"

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Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation.
Antonia Felzen, Willemien F J Hof, Hilde de Vries, Milaine V Hovingh, Rick Havinga

Biochim Biophys Acta Mol Cell Biol Lipids· January 2026

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The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice.
Tess Yntema, Tim R Eijgenraam, Niels J Kloosterhuis, Rick Havinga, Mirjam H Koster

Sci Rep· January 2025

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Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice.
Andries Heida, Theo van Dijk, Marieke Smit, Martijn Koehorst, Mirjam Koster, Rick Havinga

Biochim Biophys Acta Mol Cell Biol Lipids· March 2024

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Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Mice with a Human-like Bile Acid Composition.
Anna Palmiotti, Hilde D de Vries, Milaine V Hovingh, Martijn Koehorst, Niels L Mulder, Rick Havinga

Biomedicines· September 2023

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The chemotherapeutic drug doxorubicin does not exacerbate p16-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice.
Andrea C Postmus, Janine K Kruit, Roos E Eilers, Rick Havinga, Mirjam H Koster

Toxicol Appl Pharmacol· June 2023

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Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model.
Angela J C Tol, Kaja Hribar, Janine Kruit, Laura Bongiovanni, Marcel A Vieira-Lara, Rick Havinga

J Physiol· May 2023

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Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy.
Hannah R Wardill, Ana Rita Da Silva Ferreira, Himanshu Kumar, Emma H Bateman, Courtney B Cross, Rick Havinga

Cell Death Dis· May 2023

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Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression.
Cristy R C Verzijl, Ivo P van de Peppel, Roos E Eilers, Vincent W Bloks, Justina C Wolters, Rick Havinga

Biomed Pharmacother· March 2023

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Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice.
Jiufang Yang, Theo H van Dijk, Martijn Koehorst, Rick Havinga, Jan Freark de Boer

Int J Mol Sci· February 2023

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T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice.
Venetia Bazioti, Anouk M La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Rick Havinga

Nat Commun· July 2022

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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a.
Anouk M La Rose, Anouk G Groenen, Benedek Halmos, Venetia Bazioti, Martijn G S Rutten, Rick Havinga

Mol Genet Metab Rep· June 2022

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The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis.
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Rick Havinga

Mol Metab· December 2021

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Antibiotic-induced disruption of the microbiome exacerbates chemotherapy-induced diarrhoea and can be mitigated with autologous faecal microbiota transplantation.
Hannah R Wardill, Stijn A R van der Aa, Ana R da Silva Ferreira, Rick Havinga, Wim J E Tissing

Eur J Cancer· August 2021

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Enantiomer-specific pharmacokinetics of D,L-3-hydroxybutyrate: Implications for the treatment of multiple acyl-CoA dehydrogenase deficiency.
Willemijn J van Rijt, Johan L K Van Hove, Frédéric M Vaz, Rick Havinga, Derk P Allersma

J Inherit Metab Dis· July 2021

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Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia.
Joanne A Hoogerland, Fabian Peeks, Brenda S Hijmans, Justina C Wolters, Sander Kooijman, Rick Havinga

J Inherit Metab Dis· July 2021

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An early-life diet containing large phospholipid-coated lipid globules programmes later-life postabsorptive lipid trafficking in high-fat diet- but not in low-fat diet-fed mice.
Onne A H O Ronda, Bert J M van de Heijning, Ingrid A Martini, Martijn Koehorst, Rick Havinga

Br J Nutr· May 2021

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Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
Lori W E van der Schoor, Henkjan J Verkade, Anna Bertolini, Sanne de Wit, Elvira Mennillo, Rick Havinga

Sci Rep· May 2021

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Prophylactic Treatment with Vitamins C and B2 for Methotrexate-Induced Gastrointestinal Mucositis.
Ana Rita da Silva Ferreira, Hannah R Wardill, Rick Havinga, Wim J E Tissing, Hermie J M Harmsen

Biomolecules· December 2020

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Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet.
Onne A H O Ronda, Bert J M van de Heijning, Alain de Bruin, Rachel E Thomas, Ingrid Martini, Rick Havinga

PLoS One· October 2020

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Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice.
Onne A H O Ronda, Bert J M van de Heijning, Ingrid Martini, Albert Gerding, Justina C Wolters, Rick Havinga

Sci Rep· September 2020

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Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development.
Enchen Zhou, Geerte Hoeke, Zhuang Li, Arthur C Eibergen, Amber W Schonk, Rick Havinga

Cardiovasc Res· August 2020

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Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.
Reinout L P Roscam Abbing, Davor Slijepcevic, Joanne M Donkers, Rick Havinga, Suzanne Duijst

Hepatology· January 2020

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LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats.
Lori W E van der Schoor, Christian V Hulzebos, Martijn H van Faassen, Ido P Kema, Alain de Bruin, Rick Havinga

Pediatr Res· June 2019

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AAV8-mediated gene transfer of microRNA-132 improves beta cell function in mice fed a high-fat diet.
Niels L Mulder, Rick Havinga, Joost Kluiver, Albert K Groen, Janine K Kruit

J Endocrinol· February 2019

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Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet.
Sereana Wan, Folkert Kuipers, Rick Havinga, Hiromi Ando, Dennis E Vance

Hepatol Commun· February 2019

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