Publications by authors named "Riley D Metcalfe"

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The Structure of the Apolipoprotein A-I Monomer Provides Insights Into Its Oligomerisation and Lipid-binding Mechanisms.
Hoi In Tou, Zachary Rosenes, Yogesh Khandokar, Courtney O Zlatic, Riley D Metcalfe

J Mol Biol· November 2025

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14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state.
Juliana A Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D Metcalfe

Nat Commun· August 2025

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The structure of the IL-11 signalling complex provides insight into receptor variants associated with craniosynostosis.
Darlene D Sentosa, Riley D Metcalfe, Natalie A Sims, Tracy L Putoczki, Michael D W Griffin

FEBS J· February 2025

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14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state.
Juliana A Martinez Fiesco, Ning Li, Astrid Alvarez de la Cruz, Riley D Metcalfe, Alexandra Beilina

bioRxiv· November 2024

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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski

Nat Commun· January 2024

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Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.
Riley D Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C Kosasih

Nat Commun· November 2023

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Structure and regulation of full-length human leucine-rich repeat kinase 1.
Riley D Metcalfe, Juliana A Martinez Fiesco, Luis Bonet-Ponce, Jillian H Kluss, Mark R Cookson

Nat Commun· August 2023

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Reaction hijacking inhibition of asparagine tRNA synthetase.
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski

Res Sq· July 2023

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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang

Science· June 2022

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Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein.
Jingyu Zhan, Ericka Watts, Aaron M Brice, Riley D Metcalfe, Ashley M Rozario

J Virol· May 2022

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Emerging roles for IL-11 in inflammatory diseases.
Ka Yee Fung, Cynthia Louis, Riley D Metcalfe, Clara C Kosasih, Ian P Wicks

Cytokine· January 2022

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Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.
Ashish Sethi, Shoni Bruell, Tim Ryan, Fei Yan, Mohammad Hossein Tanipour, Riley D Metcalfe

J Mol Biol· October 2021

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Design of proteasome inhibitors with oral efficacy in vivo against and selectivity over the human proteasome.
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen

Proc Natl Acad Sci U S A· September 2021

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Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.
Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause

J Allergy Clin Immunol· August 2021

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Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Riley D Metcalfe, Tracy L Putoczki, Michael D W Griffin

Front Immunol· April 2021

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The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.
Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton

J Biol Chem· June 2020

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The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett

Nat Microbiol· November 2019

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Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase.
Jesse I Mobbs, Alex Di Paolo, Riley D Metcalfe, Emily Selig, David I Stapleton

Chembiochem· February 2018

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