Publications by authors named "Riley Perszyk"

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Inhibition of GluN2B-containing N-methyl-d-aspartate receptors by radiprodil.
Tue G Banke, Michael C Regan, Riley E Perszyk, Lu Zhang, Hao Xing

Brain· September 2025

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Selective enhancement of the interneuron network and gamma-band power via GluN2C/GluN2D NMDA receptor potentiation.
Chad R Camp, Tue G Banke, Hao Xing, Kuai Yu, Riley E Perszyk

J Physiol· July 2025

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Structural basis for channel gating and blockade in tri-heteromeric GluN1-2B-2D NMDA receptor.
Hyunook Kang, Max Epstein, Tue G Banke, Riley Perszyk, Noriko Simorowski

Neuron· April 2025

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Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.
Rui Song, Jin Zhang, Riley E Perszyk, Chad R Camp, Weiting Tang

J Neurochem· December 2024

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Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor.
Elijah Z Ullman, Riley E Perszyk, Srinu Paladugu, Russell G Fritzemeier, Nicholas S Akins

Mol Pharmacol· November 2024

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Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation.
Chad R Camp, Tue G Banke, Hao Xing, Kuai Yu, Riley E Perszyk

bioRxiv· November 2024

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De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Yuchen Xu, Rui Song, Riley E Perszyk, Wenjuan Chen, Sukhan Kim

Cell Mol Life Sci· March 2024

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Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.
James P Allen, Kathryn B Garber, Riley Perszyk, Cara T Khayat, Steven A Kell

Hum Mol Genet· February 2024

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Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.
Jesse E Hanson, Hongjie Yuan, Riley E Perszyk, Tue G Banke, Hao Xing

Neuropsychopharmacology· January 2024

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De novo CLPTM1 variants with reduced GABA R current response in patients with epilepsy.
Nana Liu, Jinliang Li, Kai Gao, Riley E Perszyk, Jing Zhang

Epilepsia· November 2023

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Clinical and functional consequences of GRIA variants in patients with neurological diseases.
Wenshu XiangWei, Riley E Perszyk, Nana Liu, Yuchen Xu, Subhrajit Bhattacharya

Cell Mol Life Sci· November 2023

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Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function.
Scott J Myers, Hongjie Yuan, Riley E Perszyk, Jing Zhang, Sukhan Kim

Hum Mol Genet· September 2023

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Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the -Methyl-d-aspartate Receptor.
Michael P D'Erasmo, Nicholas S Akins, Peipei Ma, Yao Jing, Sharon A Swanger, Riley E Perszyk

ACS Chem Neurosci· September 2023

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Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.
Lingling Xie, Miranda J McDaniel, Riley E Perszyk, Sukhan Kim, Gerarda Cappuccio

Cell Mol Life Sci· March 2023

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Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis.
Carolina Montañez-Miranda, Riley E Perszyk, Nicholas H Harbin, Jennifer Okalova, Suneela Ramineni

Mol Pharmacol· January 2023

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Opportunities for Precision Treatment of and Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors.
Wei Han, Hongjie Yuan, James P Allen, Sukhan Kim, Gil H Shaulsky, Riley E Perszyk

J Pharmacol Exp Ther· April 2022

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Kasper B Hansen, Lonnie P Wollmuth, Derek Bowie, Hiro Furukawa, Frank S Menniti, Riley E Perszyk

Pharmacol Rev· October 2021

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Three-dimensional missense tolerance ratio analysis.
Riley E Perszyk, Anders S Kristensen, Polina Lyuboslavsky, Stephen F Traynelis

Genome Res· August 2021

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Automated Intracellular Pharmacological Electrophysiology for Ligand-Gated Ionotropic Receptor and Pharmacology Screening.
Riley E Perszyk, Mighten C Yip, Ona L McConnell, Eric T Wang, Andrew Jenkins

Mol Pharmacol· July 2021

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The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca Permeability of GluN1/GluN2A -Methyl-d-Aspartate Receptors.
Riley E Perszyk, Zhaoshi Zheng, Tue G Banke, Jing Zhang, Lingling Xie

Mol Pharmacol· May 2021

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Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of -Methyl-d-aspartate Receptors.
Katie L Strong, Matthew P Epplin, Kevin K Ogden, Pieter B Burger, Thomas M Kaiser, Riley E Perszyk

ACS Chem Neurosci· January 2021

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Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif.
Riley E Perszyk, Scott J Myers, Hongjie Yuan, Alasdair J Gibb, Hiro Furukawa

J Physiol· August 2020

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Biased modulators of NMDA receptors control channel opening and ion selectivity.
Riley E Perszyk, Sharon A Swanger, Chris Shelley, Alpa Khatri, Gabriela Fernandez-Cuervo

Nat Chem Biol· February 2020

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An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.
Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin

Elife· May 2018

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