Publications by authors named "Ritsuko Iwanaga"

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Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1.
Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Mariana Fikriyanti, Ritsuko Iwanaga

Genes (Basel)· October 2025

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The Transcriptional Coactivator Gene Is a Target of the Transcription Factor E2F1 Deregulated from the Tumor Suppressor pRB.
Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Ritsuko Iwanaga

Genes (Basel)· August 2025

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EHMT1/2 Inhibition Promotes Regression of Therapy-Resistant Ovarian Cancer Tumors in a CD8 T-cell-Dependent Manner.
Lily L Nguyen, Zachary L Watson, Raquel Ortega, Elizabeth R Woodruff, Kimberly R Jordan, Ritsuko Iwanaga

Mol Cancer Res· December 2024

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DEAD/H Box 5 (DDX5) Augments E2F1-Induced Cell Death Independent of the Tumor Suppressor p53.
Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Naoyasu Nishimura, Lin Zhao, Ritsuko Iwanaga

Int J Mol Sci· December 2024

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The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2.
Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Ritsuko Iwanaga

Biomolecules· October 2024

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Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation.
Lily L Nguyen, Zachary L Watson, Raquel Ortega, Elizabeth R Woodruff, Kimberly R Jordan, Ritsuko Iwanaga

Mol Cancer Ther· September 2024

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Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma.
Ritsuko Iwanaga, Tomomi M Yamamoto, Karina Gomez, Lily L Nguyen, Elizabeth R Woodruff

Cancer Res Commun· August 2024

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Activation of the Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1.
Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Lin Zhao, Mariana Fikriyanti, Ritsuko Iwanaga

Genes (Basel)· August 2024

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Trans-Activation of the () Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1.
Rahma F Hayati, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Lin Zhao, Ritsuko Iwanaga

Genes (Basel)· May 2024

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Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression.
Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga

Biology (Basel)· December 2023

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The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F.
Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Ritsuko Iwanaga

Biochem Biophys Res Commun· June 2023

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Novel chromobox 2 inhibitory peptide decreases tumor progression.
Lindsay W Brubaker, Donald S Backos, Vu T Nguyen, Philip Reigan, Tomomi M Yamamoto, Ritsuko Iwanaga

Expert Opin Ther Targets· June 2023

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Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool.
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Ritsuko Iwanaga

Genes (Basel)· February 2023

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Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models.
Lily L Nguyen, Zachary L Watson, Raquel Ortega, Elizabeth R Woodruff, Kimberly R Jordan, Ritsuko Iwanaga

bioRxiv· February 2023

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Loss of prdm1a accelerates melanoma onset and progression.
Ritsuko Iwanaga, Brittany T Truong, Jessica Y Hsu, Karoline A Lambert, Rajesh Vyas

Mol Carcinog· September 2020

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Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.
Hideyuki Komori, Yasuko Goto, Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga

Sci Rep· May 2018

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The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity.
Kenta Kurayoshi, Junko Okuno, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford

Biochem Biophys Res Commun· January 2017

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Ectopic expression of the CDK inhibitor p21 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter.
Kenta Kurayoshi, Ayumi Shiromoto, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford

Biochem Biophys Res Commun· January 2017

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Comparative histology of mouse, rat, and human pelvic ligaments.
Ritsuko Iwanaga, David J Orlicky, Jameson Arnett, Marsha K Guess, K Joseph Hurt

Int Urogynecol J· November 2016

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Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.
Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Junko Okuno

Genes Cells· September 2015

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Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3.
Chu-An Wang, J Chuck Harrell, Ritsuko Iwanaga, Paul Jedlicka, Heide L Ford

Breast Cancer Res· October 2014

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Tumor suppressor TAp73 gene specifically responds to deregulated E2F activity in human normal fibroblasts.
Eiko Ozono, Hideyuki Komori, Ritsuko Iwanaga, Tatsuya Tanaka, Takahiro Sakae

Genes Cells· August 2012

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Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways.
Ritsuko Iwanaga, Chu-An Wang, Douglas S Micalizzi, J Chuck Harrell, Paul Jedlicka

Breast Cancer Res· July 2012

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Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer.
Lubna Qamar, Erin Deitsch, Aaron N Patrick, Miriam D Post, Monique A Spillman, Ritsuko Iwanaga

Gynecol Oncol· May 2012

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