Publications by authors named "Rob C Roovers"

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Author Correction: Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies.
Jord C Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Rob C Roovers

Sci Rep· April 2025

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Leveraging Vγ9Vδ2 T cells against prostate cancer through a VHH-based PSMA-Vδ2 bispecific T cell engager.
Lisa A King, Myrthe Veth, Victoria Iglesias-Guimarais, Iris Blijdorp, Jan Kloosterman, Rob C Roovers

iScience· December 2024

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Structural insights into the role and targeting of EGFRvIII.
Atrish Bagchi, Steven E Stayrook, Katerina T Xenaki, Chrystal A Starbird, Sofia Doulkeridou, Rob C Roovers

Structure· September 2024

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A Bispecific γδ T-cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T cell-Mediated Immune Response against EGFR-Expressing Tumors.
Lisa A King, Elisa C Toffoli, Myrthe Veth, Victoria Iglesias-Guimarais, Manon C Slot, Rob C Roovers

Cancer Immunol Res· September 2023

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A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies.
Roeland Lameris, Jurjen M Ruben, Victoria Iglesias-Guimarais, Milon de Jong, Myrthe Veth, Rob C Roovers

Cell Rep Med· March 2023

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Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies.
Jord C Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Rob C Roovers

Sci Rep· August 2022

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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
Bram Herpers, Berina Eppink, Mark I James, Carme Cortina, Adrià Cañellas-Socias, Rob C Roovers

Nat Cancer· April 2022

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A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies.
Iris de Weerdt, Roeland Lameris, George L Scheffer, Jana Vree, Renate de Boer, Rob C Roovers

Cancer Immunol Res· January 2021

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MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis.
Pieter Fokko van Loo, Basav N Hangalapura, Soley Thordardottir, John D Gibbins, Henrike Veninga, Rob C Roovers

Expert Opin Biol Ther· July 2019

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The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Laura C Zanetti-Domingues, Dimitrios Korovesis, Sarah R Needham, Christopher J Tynan, Shiori Sagawa, Rob C Roovers

Nat Commun· October 2018

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A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells.
Renée C G de Bruin, John P Veluchamy, Sinéad M Lougheed, Famke L Schneiders, Silvia Lopez-Lastra, Rob C Roovers

Oncoimmunology· October 2017

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High affinity nanobodies against human epidermal growth factor receptor selected on cells by E. coli display.
Valencio Salema, Carmen Mañas, Lidia Cerdán, Carlos Piñero-Lambea, Elvira Marín, Rob C Roovers

MAbs· October 2016

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Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.
Renée C G de Bruin, Sinéad M Lougheed, Liza van der Kruk, Anita G Stam, Erik Hooijberg, Rob C Roovers

Clin Immunol· August 2016

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Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics.
Alex Klarenbeek, Christophe Blanchetot, Georg Schragel, Ava S Sadi, Nico Ongenae, Rob C Roovers

Protein Eng Des Sel· April 2016

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Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Alex Klarenbeek, Khalil El Mazouari, Aline Desmyter, Christophe Blanchetot, Anna Hultberg, Rob C Roovers

MAbs· March 2016

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Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles.
Raimond Heukers, Isil Altintas, Smiriti Raghoenath, Erica De Zan, Richard Pepermans, Rob C Roovers

Biomaterials· January 2014

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Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif.
Raimond Heukers, Jeroen F Vermeulen, Farzad Fereidouni, Arjen N Bader, Jarno Voortman, Rob C Roovers

J Cell Sci· November 2013

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Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains.
Karl R Schmitz, Atrish Bagchi, Rob C Roovers, Paul M P van Bergen en Henegouwen, Kathryn M Ferguson

Structure· July 2013

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Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Dietmar M W Zaiss, Jorg van Loosdregt, Andrea Gorlani, Cornelis P J Bekker, Andrea Gröne, Rob C Roovers

Immunity· February 2013

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Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects.
Jeroen A J M van de Water, Tugba Bagci-Onder, Aayush S Agarwal, Hiroaki Wakimoto, Rob C Roovers

Proc Natl Acad Sci U S A· October 2012

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Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment.
Roy van der Meel, Sabrina Oliveira, Isil Altintas, Rob Haselberg, Joris van der Veeken, Rob C Roovers

J Control Release· April 2012

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Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-epidermal growth factor receptor nanobody.
Sabrina Oliveira, Guus A M S van Dongen, Marijke Stigter-van Walsum, Rob C Roovers, Jord C Stam

Mol Imaging· February 2012

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A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.
Rob C Roovers, Maria J W D Vosjan, Toon Laeremans, Rachid el Khoulati, Renée C G de Bruin

Int J Cancer· October 2011

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ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.
Shalini T Low-Nam, Keith A Lidke, Patrick J Cutler, Rob C Roovers, Paul M P van Bergen en Henegouwen

Nat Struct Mol Biol· October 2011

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Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET.
Maria J W D Vosjan, Lars R Perk, Rob C Roovers, Gerard W M Visser, Marijke Stigter-van Walsum

Eur J Nucl Med Mol Imaging· April 2011

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