Publications by authors named "Rob C van Wijk"

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Translational Modeling of BTZ-043 to Predict Phase 2A Efficacy and Evaluate Drug-Drug Interactions With Bedaquiline, Pretomanid, and Linezolid in Murine Models.
Bernard Ngara, Lorenzo Flori, Rob Christiaan van Wijk, Jacqueline P Ernest, Sandeep Tyagi

J Infect Dis· June 2025

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Predicting tuberculosis drug efficacy in preclinical and clinical models from data.
Janice J N Goh, Anu Patel, Bernard Ngara, Rob C van Wijk, Natasha Strydom

iScience· March 2025

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Selection and prioritization of candidate combination regimens for the treatment of tuberculosis.
Natasha Strydom, Rob C van Wijk, Qianwen Wang, Jacqueline P Ernest, Linda Chaba

Sci Transl Med· February 2025

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Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic.
Laurynas Mockeliunas, Rob C van Wijk, Caryn M Upton, Jonathan Peter, Andreas H Diacon

Vaccines (Basel)· March 2024

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Pharmacokinetic analysis across studies to drive knowledge-integration: A tutorial on individual patient data meta-analysis (IPDMA).
Rob C van Wijk, Marjorie Z Imperial, Radojka M Savic, Belén P Solans

CPT Pharmacometrics Syst Pharmacol· September 2023

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Seasonal influence on respiratory tract infection severity including COVID-19 quantified through Markov Chain modeling.
Rob C van Wijk, Laurynas Mockeliunas, Caryn M Upton, Jonathan Peter, Andreas H Diacon

CPT Pharmacometrics Syst Pharmacol· September 2023

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Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.
Rob C van Wijk, Laurynas Mockeliunas, Gerben van den Hoogen, Caryn M Upton, Andreas H Diacon

Sci Rep· September 2023

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Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs.
Jacqueline P Ernest, Janice Jia Ni Goh, Natasha Strydom, Qianwen Wang, Rob C van Wijk

Eur Respir J· August 2023

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Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy.
Alan Faraj, Rob C van Wijk, Linda Neuman, Shraddha Desai, Grant E Blouse

CPT Pharmacometrics Syst Pharmacol· July 2023

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Implementing best practices on data generation and reporting of assays within the ERA4TB consortium.
Rob C van Wijk, Ainhoa Lucía, Pavan Kumar Sudhakar, Lindsay Sonnenkalb, Cyril Gaudin

iScience· April 2023

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Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development.
Laurynas Mockeliunas, Alan Faraj, Rob C van Wijk, Caryn M Upton, Gerben van den Hoogen

Front Pharmacol· April 2023

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Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs.
Jacqueline P Ernest, Janice Jia Ni Goh, Natasha Strydom, Qianwen Wang, Rob C van Wijk

bioRxiv· January 2023

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Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application.
Rob C Van Wijk, Ulrika S H Simonsson

CPT Pharmacometrics Syst Pharmacol· August 2022

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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.
Caryn M Upton, Rob C van Wijk, Laurynas Mockeliunas, Ulrika S H Simonsson, Kirsten McHarry

EClinicalMedicine· June 2022

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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.
Veronique De Jager, Nikhil Gupte, Silvia Nunes, Grace L Barnes, Rob Christiaan van Wijk

Am J Respir Crit Care Med· May 2022

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Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans.
Rob C van Wijk, Wanbin Hu, Sharka M Dijkema, Dirk-Jan van den Berg, Jeremy Liu

Br J Pharmacol· December 2020

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Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development.
Rob C Van Wijk, Astrid M van der Sar, Elke H J Krekels, Theo Verboom, Herman P Spaink

Clin Transl Sci· November 2020

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Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.
Rob C Van Wijk, Elke H J Krekels, Vasudev Kantae, Anita Ordas, Thijs Kreling

J Pharmacol Exp Ther· October 2019

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Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.
Rob C van Wijk, Elke H J Krekels, Vasudev Kantae, Amy C Harms, Thomas Hankemeier

Sci Rep· February 2019

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Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies.
Pascal Schulthess, Rob C van Wijk, Elke H J Krekels, James W T Yates, Herman P Spaink

CPT Pharmacometrics Syst Pharmacol· May 2018

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Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.
Yin Cheong Wong, Trayana Ilkova, Rob C van Wijk, Robin Hartman, Elizabeth C M de Lange

Eur J Pharm Sci· January 2018

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Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.
Vasudev Kantae, Elke H J Krekels, Anita Ordas, Oskar González, Rob C van Wijk

Zebrafish· December 2016

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Integration of PKPD relationships into benefit-risk analysis.
Francesco Bellanti, Rob C van Wijk, Meindert Danhof, Oscar Della Pasqua

Br J Clin Pharmacol· November 2015

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