Publications by authors named "Robert D Guzy"

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Active Antigen-Specific Adaptive Immune Responses Are Shared among Patients with Progressive Fibrotic Interstitial Lung Disease.
Tania E Velez, Young Me Yoon, Vaibhav Upadhyay, Sara E Vazquez, Cathryn T Lee, Robert D Guzy

Am J Respir Crit Care Med· October 2025

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Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation.
Nowrin U Chowdhury, Jacqueline-Yvonne Cephus, Emely Henriquez Pilier, Melissa M Wolf, Matthew Z Madden, Robert D Guzy

J Clin Invest· October 2024

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Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies.
Young Me Yoon, Tania E Velez, Vaibhav Upadhyay, Sara E Vazquez, Cathryn T Lee, Robert D Guzy

medRxiv· May 2023

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From the Gut to the Lung: Evidence of Antifibrotic Activity of Endocrine Fibroblast Growth Factor 19.
Robert D Guzy, Seth Bollenbecker, Stefanie Krick

Am J Respir Cell Mol Biol· August 2022

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SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
David Wu, Tzu-Han Lee, Ru-Ting Huang, Robert D Guzy, Nathan Schoettler

Am J Respir Cell Mol Biol· August 2021

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Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Tzu-Han Lee, Chih-Fan Yeh, Ying-Tung Lee, Ying-Chun Shih, Yen-Ting Chen, Robert D Guzy

Nat Commun· August 2020

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Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model.
Lamis M F El-Baz, Nahla M Shoukry, Hani S Hafez, Robert D Guzy, Mohamed Labib Salem

Iran J Allergy Asthma Immunol· August 2020

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FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.
Samuel J Dorry, Brandon O Ansbro, David M Ornitz, Gökhan M Mutlu, Robert D Guzy

Am J Respir Cell Mol Biol· May 2020

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Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts.
Ahmed E Hegab, Mari Ozaki, Naofumi Kameyama, Jingtao Gao, Shizuko Kagawa, Robert D Guzy

J Pathol· October 2019

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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Paul A Reyfman, James M Walter, Nikita Joshi, Kishore R Anekalla, Alexandra C McQuattie-Pimentel, Robert D Guzy

Am J Respir Crit Care Med· June 2019

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Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β.
Shawn Ard, Eleanor B Reed, Larisa V Smolyaninova, Sergei N Orlov, Gökhan M Mutlu, Robert D Guzy

Am J Respir Cell Mol Biol· March 2019

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Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
Hyun Young Koo, Lamis Mf El-Baz, StaceyL House, Sarah N Cilvik, Samuel J Dorry, Robert D Guzy

J Pathol· September 2018

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Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Robert B Hamanaka, Recep Nigdelioglu, Angelo Y Meliton, Yufeng Tian, Leah J Witt, Robert D Guzy

Am J Respir Cell Mol Biol· May 2018

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Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.
Robert D Guzy, Ling Li, Craig Smith, Samuel J Dorry, Hyun Young Koo

J Biol Chem· June 2017

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Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.
Robert D Guzy, Ivan Stoilov, Timothy J Elton, Robert P Mecham, David M Ornitz

Am J Respir Cell Mol Biol· January 2015

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YKL-40 in pediatric asthma, MUC5B promoter polymorphism in idiopathic pulmonary fibrosis, and esmolol in septic shock.
Hrishikesh S Kulkarni, Robert D Guzy, Colleen McEvoy

Am J Respir Crit Care Med· May 2014

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Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.
Gregory B Waypa, Jeremy D Marks, Robert D Guzy, Paul T Mungai, Jacqueline M Schriewer

Am J Respir Crit Care Med· February 2013

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Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.
Gabriel Loor, Jyothisri Kondapalli, Hirotaro Iwase, Navdeep S Chandel, Gregory B Waypa, Robert D Guzy

Biochim Biophys Acta· July 2011

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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Robert D Guzy, Bhumika Sharma, Eric Bell, Navdeep S Chandel, Paul T Schumacker

Mol Cell Biol· January 2008

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Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast.
Robert D Guzy, Matthew M Mack, Paul T Schumacker

Antioxid Redox Signal· September 2007

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Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes.
Hirotaro Iwase, Emmanuel Robin, Robert D Guzy, Paul T Mungai, Terry L Vanden Hoek

Free Radic Biol Med· August 2007

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Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion.
Emmanuel Robin, Robert D Guzy, Gabriel Loor, Hirotaro Iwase, Gregory B Waypa

J Biol Chem· June 2007

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Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.
Robert D Guzy, Paul T Schumacker

Exp Physiol· September 2006

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.
Kyle D Mansfield, Robert D Guzy, Yi Pan, Regina M Young, Timothy P Cash

Cell Metab· June 2005

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Robert D Guzy, Beatrice Hoyos, Emmanuel Robin, Hong Chen, Liping Liu

Cell Metab· June 2005

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