Publications by authors named "Robert Doot"

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PET imaging with [¹¹C]CHDI-00485180-R, designed as radioligand for aggregated mutant huntingtin, in people with Huntington's disease.
Aline Delva, Michel Koole, Kim Serdons, Guy Bormans, Mette Skinbjerg, Robert Doot

Eur J Nucl Med Mol Imaging· November 2025

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In Vivo PET Imaging of [F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease.
Franziska Zajicek, Filipe Elvas, Alan Miranda, Jordy Akkermans, Jeroen Verhaeghe, Robert Doot

J Nucl Med· November 2025

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First-in-Human Biodistribution and Dosimetry of [C]Trimethoprim.
Anthony J Young, Robert K Doot, Joshua K Cho, Jonathan M Pham, Alvaro A Ordonez

Mol Imaging Biol· November 2025

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Pharmacokinetic effects of a single-dose nutritional ketone ester supplement on brain glucose and ketone metabolism in alcohol use disorder.
Xinyi Li, Anthony J Young, Zhenhao Shi, Juliana Byanyima, Sianneh Vesslee, Robert K Doot

medRxiv· March 2025

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Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted F-Fluorthanatrace PET in Breast Cancer.
Anthony J Young, Austin R Pantel, Mahsa Kiani, Robert K Doot, Sina Bagheri

J Nucl Med· December 2024

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Biodistribution and dosimetry of the PET radioligand [F]CHDI-650 in mice for detection of mutant huntingtin aggregates.
Jordy Akkermans, Alan Miranda, Jeroen Verhaeghe, Filipe Elvas, Franziska Zajicek, Robert Doot

EJNMMI Res· December 2024

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Distinguishing Progression from Pseudoprogression in Glioblastoma Using F-Fluciclovine PET.
Ali Nabavizadeh, Stephen J Bagley, Robert K Doot, Jeffrey B Ware, Anthony J Young

J Nucl Med· June 2023

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Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study.
Reagan R Wetherill, Robert K Doot, Anthony J Young, Hsiaoju Lee, Erin K Schubert

J Nucl Med· May 2023

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[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study.
Austin R Pantel, Sarah B Gitto, Mehran Makvandi, Hyoung Kim, Sergey Medvedv, Robert K Doot

Clin Cancer Res· April 2023

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Preliminary Evaluation of Ga-P16-093, a PET Radiotracer Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
Hwan Lee, Joshua S Scheuermann, Anthony J Young, Robert K Doot, Margaret E Daube-Witherspoon

Mol Imaging Biol· October 2022

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Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim.
Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Robert K Doot

J Clin Invest· September 2022

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[F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease.
Robert K Doot, Anthony J Young, Ilya M Nasrallah, Reagan R Wetherill, Andrew Siderowf

Cells· September 2022

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Principles of Tracer Kinetic Analysis in Oncology, Part II: Examples and Future Directions.
Austin R Pantel, Varsha Viswanath, Mark Muzi, Robert K Doot, David A Mankoff

J Nucl Med· April 2022

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Principles of Tracer Kinetic Analysis in Oncology, Part I: Principles and Overview of Methodology.
Austin R Pantel, Varsha Viswanath, Mark Muzi, Robert K Doot, David A Mankoff

J Nucl Med· March 2022

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Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted F-Fluorthanatrace PET Images of Ovarian Cancer.
Anthony J Young, Austin R Pantel, Varsha Viswanath, Tiffany L Dominguez, Mehran Makvandi, Robert K Doot

J Nucl Med· January 2022

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The Development of F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1.
Hsiaoju S Lee, Sally W Schwarz, Erin K Schubert, Delphine L Chen, Robert K Doot

Radiol Imaging Cancer· January 2022

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Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology.
Michael Tran Duong, Yin Jie Chen, Robert K Doot, Anthony J Young, Hsiaoju Lee

Nucl Med Commun· November 2021

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Kinetic Modeling of F-(24)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism.
Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K Doot

J Nucl Med· August 2021

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F-fluorodeoxyglucose (FDG) PET or F-fluorothymidine (FLT) PET to assess early response to aromatase inhibitors (AI) in women with ER+ operable breast cancer in a window-of-opportunity study.
Perrin E Romine, Lanell M Peterson, Brenda F Kurland, Darrin W Byrd, Alena Novakova-Jiresova, Robert K Doot

Breast Cancer Res· August 2021

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Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies.
Robert K Doot, Anthony J Young, Margaret E Daube-Witherspoon, David Alexoff, Kyle J Labban

Nucl Med Biol· July 2021

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In vivo visualization of PARP inhibitor pharmacodynamics.
Elizabeth S McDonald, Austin R Pantel, Payal D Shah, Michael D Farwell, Amy S Clark, Robert K Doot

JCI Insight· April 2021

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Preoperative breast MR imaging in newly diagnosed breast cancer: Comparison of outcomes based on mammographic modality, breast density and breast parenchymal enhancement.
Azadeh Elmi, Emily F Conant, Andrew Kozlov, Anthony J Young, Qi Long, Robert K Doot

Clin Imaging· February 2021

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Quantifying bias and precision of kinetic parameter estimation on the PennPET Explorer, a long axial field-of-view scanner.
Varsha Viswanath, Austin R Pantel, Margaret E Daube-Witherspoon, Robert Doot, Mark Muzi

IEEE Trans Radiat Plasma Med Sci· November 2020

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Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial.
Elizabeth S McDonald, Robert K Doot, Austin R Pantel, Michael D Farwell, Robert H Mach

JAMA Oncol· June 2020

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F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling.
Fraser Henderson, Steven Brem, Donald M O'Rourke, MacLean Nasrallah, Vivek P Buch, Robert K Doot

Neurooncol Pract· March 2020

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