Publications by authors named "Robert Gladding"

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In Vivo Evaluation of 6 Analogs of C-ER176 as Candidate F-Labeled Radioligands for 18-kDa Translocator Protein.
Jae-Hoon Lee, Fabrice G Siméon, Jeih-San Liow, Cheryl L Morse, Robert L Gladding

J Nucl Med· August 2022

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Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising F-Labeled Ligand.
Fabrice G Siméon, Jae-Hoon Lee, Cheryl L Morse, Ian Stukes, Sami S Zoghbi, Robert L Gladding

J Med Chem· November 2021

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[C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain.
Xuefeng Yan, Sanjay Telu, Rachel M Dick, Jeih-San Liow, Paolo Zanotti-Fregonara, Robert L Gladding

J Cereb Blood Flow Metab· October 2021

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Synthesis of [F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey.
Carlotta Taddei, Cheryl L Morse, Min-Jeong Kim, Jeih-San Liow, Jose Montero Santamaria, Robert L Gladding

ACS Chem Neurosci· February 2021

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Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D.
Yuichi Wakabayashi, Sanjay Telu, Rachel M Dick, Masahiro Fujita, Maarten Ooms, Robert L Gladding

ACS Chem Neurosci· May 2020

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PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study.
Stal Shrestha, Min-Jeong Kim, Mark Eldridge, Michael L Lehmann, Michael Frankland, Robert L Gladding

J Neuroinflammation· May 2020

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PET ligands [F]LSN3316612 and [C]LSN3316612 quantify -linked-β--acetyl-glucosamine hydrolase in the brain.
Shuiyu Lu, Mohammad B Haskali, Kevin M Ruley, Nicolas J-F Dreyfus, Susan L DuBois, Robert L Gladding

Sci Transl Med· May 2020

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Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT receptors.
Anton Lindberg, Shuiyu Lu, Sangram Nag, Magnus Schou, Jeih-San Liow, Robert L Gladding

Nucl Med Biol· March 2019

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Evaluation of a PET Radioligand to Image -GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse.
Soumen Paul, Mohammad B Haskali, Jeih-San Liow, Sami S Zoghbi, Vanessa N Barth, Robert L Gladding

J Nucl Med· January 2019

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Evaluation of Two Potent and Selective PET Radioligands to Image COX-1 and COX-2 in Rhesus Monkeys.
Min-Jeong Kim, Stal S Shrestha, Michelle Cortes, Prachi Singh, Cheryl Morse, Robert L Gladding

J Nucl Med· December 2018

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3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [C]PS13 for Quantitative Imaging.
Stal Shrestha, Prachi Singh, Michelle Y Cortes-Salva, Kimberly J Jenko, Masamichi Ikawa, Robert L Gladding

ACS Chem Neurosci· November 2018

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[--C]-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1-indole-2-carboxamide ([C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey.
Jeih-San Liow, Cheryl L Morse, Shuiyu Lu, Michael Frankland, George L Tye, Robert L Gladding

Molecules· October 2018

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The PET Radioligand 18F-FIMX Images and Quantifies Metabotropic Glutamate Receptor 1 in Proportion to the Regional Density of Its Gene Transcript in Human Brain.
Paolo Zanotti-Fregonara, Rong Xu, Sami S Zoghbi, Jeih-San Liow, Masahiro Fujita, Robert L Gladding

J Nucl Med· February 2016

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[carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain.
Jinsoo Hong, Shuiyu Lu, Rong Xu, Jeih-San Liow, Alicia E Woock, Robert L Gladding

Nucl Med Biol· December 2015

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Evaluation in monkey of two candidate PET radioligands, [ C]RX-1 and [ F]RX-2, for imaging brain 5-HT receptors.
Talakad G Lohith, Rong Xu, Tetsuya Tsujikawa, Cheryl L Morse, Kacey B Anderson, Robert L Gladding

Synapse· December 2014

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Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.
Paolo Zanotti-Fregonara, Yi Zhang, Kimberly J Jenko, Robert L Gladding, Sami S Zoghbi

ACS Chem Neurosci· October 2014

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Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior.
Stal Saurav Shrestha, Eric E Nelson, Jeih-San Liow, Robert Gladding, Chul Hyoung Lyoo

Am J Psychiatry· March 2014

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In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors.
Tetsuya Tsujikawa, Sami S Zoghbi, Jinsoo Hong, Sean R Donohue, Kimberly J Jenko, Robert L Gladding

Neuroimage· January 2014

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(11)C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α(1) adrenoceptors in brain.
Stal Saurav Shrestha, Jeih-San Liow, Shuiyu Lu, Kimberly Jenko, Robert L Gladding

J Nucl Med· January 2014

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Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1).
Rong Xu, Paolo Zanotti-Fregonara, Sami S Zoghbi, Robert L Gladding, Alicia E Woock

J Med Chem· November 2013

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11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains.
Paolo Zanotti-Fregonara, Vanessa N Barth, Sami S Zoghbi, Jeih-San Liow, Eric Nisenbaum, Robert L Gladding

EJNMMI Res· June 2013

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Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors.
Fabrice G Siméon, Jeih-San Liow, Yi Zhang, Jinsoo Hong, Robert L Gladding

Eur J Nucl Med Mol Imaging· December 2012

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Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.
Xiaofeng Bao, Shuiyu Lu, Jeih-San Liow, Sami S Zoghbi, Kimberly J Jenko, Robert L Gladding

J Med Chem· March 2012

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Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors.
Yasuyuki Kimura, Masahiro Fujita, Jinsoo Hong, Talakad G Lohith, Robert L Gladding

J Nucl Med· October 2011

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Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function.
Paolo Zanotti-Fregonara, Sami S Zoghbi, Jeih-San Liow, Elise Luong, Ronald Boellaard, Robert L Gladding

Neuroimage· February 2011

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