Publications by authors named "Robert Hepler"

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Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.
Chengwei Wu, Izzat T Raheem, Debbie D Nahas, Michael Citron, Peter S Kim, Robert W Hepler

Proc Natl Acad Sci U S A· May 2024

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Orthogonal Comparison of Analytical Methods by Theoretical Reconstruction from Bottom-up Assay Data.
Andrew C Nichols, Yong Joo Kil, Andrew Mahan, Bo Zhai, Robert Hepler

J Am Soc Mass Spectrom· August 2021

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Surfactant Impact on Interfacial Protein Aggregation and Utilization of Surface Tension to Predict Surfactant Requirements for Biological Formulations.
Kevin B Vargo, Patrick Stahl, Brian Hwang, Erica Hwang, Daniel Giordano, Robert Hepler

Mol Pharm· January 2021

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COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia.
Kristina Klupsch, Vanessa Baeriswyl, Roland Scholz, Joana Dannenberg, Roger Santimaria, Robert W Hepler

Leukemia· March 2019

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Spectroscopic analysis of chlamydial major outer membrane protein in support of structure elucidation.
Robert W Hepler, Debbie D Nahas, Bob Lucas, Robin Kaufhold, Jessica A Flynn

Protein Sci· November 2018

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Detection and Measurement of Methionine Oxidation in Proteins.
K Ilker Sen, Robert Hepler, Hirsh Nanda

Curr Protoc Protein Sci· February 2017

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Protection of rhesus macaques against inhalational anthrax with a Bacillus anthracis capsule conjugate vaccine.
Donald J Chabot, Wilson J Ribot, Joseph Joyce, James Cook, Robert Hepler

Vaccine· July 2016

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Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex.
Craig Przysiecki, Bob Lucas, Robert Mitchell, Daniel Carapau, Zhiyun Wen, Robert Hepler

Front Cell Infect Microbiol· December 2013

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Immunogenicity in mice and non-human primates of the Group A Streptococcal J8 peptide vaccine candidate conjugated to CRM197.
Ivette Caro-Aguilar, Elizabeth Ottinger, Robert W Hepler, Deborah D Nahas, Chengwei Wu

Hum Vaccin Immunother· March 2013

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Efficacy of a capsule conjugate vaccine against inhalational anthrax in rabbits and monkeys.
Donald J Chabot, Joseph Joyce, Michael Caulfield, James Cook, Robert Hepler

Vaccine· January 2012

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High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays.
Wei-Qin Zhao, Dawn Toolan, Robert W Hepler, Abigail L Wolfe, Yuanjiang Yu

J Alzheimers Dis· November 2011

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Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads.
Michael J Caulfield, Vadim Y Dudkin, Elizabeth A Ottinger, Krista L Getty, Paul D Zuck, Robert W Hepler

J Biol Chem· December 2010

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Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge.
Gayathri Bommakanti, Michael P Citron, Robert W Hepler, Cheryl Callahan, Gwendolyn J Heidecker

Proc Natl Acad Sci U S A· August 2010

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Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Renee C Gaspar, Stephanie A Villarreal, Nicole Bowles, Robert W Hepler, Joseph G Joyce

Exp Neurol· June 2010

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Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.
Elisabetta Bianchi, Joseph G Joyce, Michael D Miller, Adam C Finnefrock, Xiaoping Liang, Robert W Hepler

Proc Natl Acad Sci U S A· June 2010

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Staphylococcus aureus capsule type 8 antibodies provide inconsistent efficacy in murine models of staphylococcal infection.
James Cook, Robert Hepler, Greg Pancari, Nelly Kuklin, Hongxia Fan

Hum Vaccin· April 2009

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Amino acid analysis of peptide loading ratios in conjugate vaccines: a comparison of direct electrochemical detection and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate pre-column derivatization methods.
Deborah D Nahas, Jennifer S Palladino, Joseph G Joyce, Robert W Hepler

Bioconjug Chem· January 2008

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Solution state characterization of amyloid beta-derived diffusible ligands.
Robert W Hepler, Karen M Grimm, Deborah D Nahas, Robert Breese, Elizabeth Chen Dodson

Biochemistry· December 2006

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A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection.
Robert W Hepler, Rosemarie Kelly, Tessie B McNeely, Hongxia Fan, Maria C Losada

Vaccine· March 2006

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Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategy.
Joseph Joyce, James Cook, Donald Chabot, Robert Hepler, Wesley Shoop

J Biol Chem· February 2006

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Isolation, structural characterization, and immunological evaluation of a high-molecular-weight exopolysaccharide from Staphylococcus aureus.
Joseph G Joyce, Chitrananda Abeygunawardana, Qiuwei Xu, James C Cook, Robert Hepler

Carbohydr Res· April 2003

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