Publications by authors named "Robert L Sprando"

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The worm Development and Activity Test (wDAT) can be used to differentiate between reversible and irreversible developmental effects.
Piper Reid Hunt, Nicholas Olejnik, Jeffrey Yourick, Robert L Sprando

Toxicol Rep· December 2025

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Safety pharmacology of sibutramine analogues evaluated by in silico and in vitro biological target screening.
Michael F Santillo, Robert L Sprando

Chem Biol Interact· October 2025

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Developmental Exposures to Three Mammalian Teratogens Produce Dysmorphic Phenotypes in Adult .
Piper Reid Hunt, Martine Ferguson, Nicholas Olejnik, Jeffrey Yourick, Robert L Sprando

Toxics· July 2025

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Assessment of intestinal absorption of five cannabinoids from an ethanolic CBD-rich hemp extract using Caco-2 cells in vitro.
Magali Araujo, Erica Stewart, Yang Zhao, Estatira Sepehr, Cory Vaught, Robert L Sprando

Toxicol In Vitro· June 2025

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Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an model for assessing population variability in hepatotoxicity testing.
Xiugong Gao, Rong Li, Kayla Campasino, Miranda R Yourick, Yang Zhao, Robert L Sprando

Curr Res Toxicol· May 2025

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An updated comparison of microarray and RNA-seq for concentration response transcriptomic study: case studies with two cannabinoids, cannabichromene and cannabinol.
Xiugong Gao, Miranda R Yourick, Kayla Campasino, Yang Zhao, Estatira Sepehr, Robert L Sprando

BMC Genomics· April 2025

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Effect of cannabidiol and hemp extract on viability and function of hepatocytes derived from human induced pluripotent stem cells.
Kayla Campasino, Miranda R Yourick, Yang Zhao, Estatira Sepehr, Cory Vaught, Robert L Sprando

Toxicol In Vitro· December 2024

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Biological Target Screening and Colloidal Aggregation of Minor Cannabinoids.
Michael F Santillo, Isabella S Glenn, Lu Paris, Robert L Sprando

J Nat Prod· December 2024

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Strengths and limitations of the worm development and activity test (wDAT) as a chemical screening tool for developmental hazards.
Piper Reid Hunt, Bonnie Welch, Jessica Camacho, Joelle K Salazar, Megan L Fay, Robert L Sprando

Toxicol Appl Pharmacol· November 2024

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Assessment of the effects of cannabidiol and a CBD-rich hemp extract in .
Jessica A Camacho, Bonnie Welch, Martine Ferguson, Estatira Sepehr, Cory Vaught, Robert L Sprando

Front Toxicol· October 2024

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Oxidative DNA damage contributes to usnic acid-induced toxicity in human induced pluripotent stem cell-derived hepatocytes.
Xiugong Gao, Kayla Campasino, Miranda R Yourick, Yu Cao, Jeffrey J Yourick, Robert L Sprando

J Appl Toxicol· September 2024

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Hepatotoxicity of silver nanoparticles: Benchmark concentration modeling of an in vitro transcriptomics study in human iPSC-derived hepatocytes.
Xiugong Gao, W Evan Johnson, Miranda R Yourick, Kayla Campasino, Robert L Sprando

Regul Toxicol Pharmacol· August 2024

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Comparison on the mechanism and potency of hepatotoxicity among hemp extract and its four major constituent cannabinoids.
Xiugong Gao, Kayla Campasino, Miranda R Yourick, Yang Zhao, Estatira Sepehr, Robert L Sprando

Toxicology· August 2024

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The worm Adult Activity Test (wAAT): A de novo mathematical model for detecting acute chemical effects in Caenorhabditis elegans.
Piper Reid Hunt, Bonnie Welch, Jessica Camacho, Priyanka N Bushana, Hugh Rand, Robert L Sprando

J Appl Toxicol· December 2023

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Predicting binding between 55 cannabinoids and 4,799 biological targets by in silico methods.
Michael F Santillo, Robert L Sprando

J Appl Toxicol· October 2023

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Toxicological applications of human induced pluripotent stem cell-derived hepatocyte-like cells: an updated review.
Xiugong Gao, Jeffrey J Yourick, Robert L Sprando

J Toxicol Sci· August 2023

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Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues.
Yitong Liu, Robert L Sprando

J Appl Toxicol· April 2023

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Picamilon, a γ-aminobutyric acid (GABA) analogue and marketed nootropic, is inactive against 50 biological targets.
Michael F Santillo, Robert L Sprando

Basic Clin Pharmacol Toxicol· April 2023

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Reproductive-Toxicity-Related Endpoints in Are Consistent with Reduced Concern for Dimethylarsinic Acid Exposure Relative to Inorganic Arsenic.
Jessica A Camacho, Bonnie Welch, Robert L Sprando, Piper R Hunt

J Dev Biol· April 2023

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Development and validation of a fit-for-purpose UHPLC-ESI-MS/MS method for the quantitation of cannabinoids in different matrices.
Yang Zhao, Estatira Sepehr, Cory Vaught, Jeffrey Yourick, Robert L Sprando

J Chromatogr B Analyt Technol Biomed Life Sci· March 2023

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A transcriptomic dataset comparing two methods of hepatocyte differentiation from human induced pluripotent stem cells.
Xiugong Gao, Rong Li, Jeffrey J Yourick, Robert L Sprando

Data Brief· August 2022

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Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells.
Rong Li, Yang Zhao, Jeffrey J Yourick, Robert L Sprando, Xiugong Gao

Biomed Rep· May 2022

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Rapid and Highly Efficient Isolation and Purification of Human Induced Pluripotent Stem Cells.
Xiugong Gao, Robert L Sprando, Jeffrey J Yourick

Methods Mol Biol· May 2022

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Homogeneous Differentiation of Functional Hepatocytes from Human Induced Pluripotent Stem Cells.
Rong Li, Yang Zhao, Jeffrey J Yourick, Robert L Sprando, Xiugong Gao

Methods Mol Biol· May 2022

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Assessment of the effects of organic vs. inorganic arsenic and mercury in .
Jessica Camacho, Aline de Conti, Igor P Pogribny, Robert L Sprando, Piper Reid Hunt

Curr Res Toxicol· May 2022

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