Publications by authors named "Robert Lechler"

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Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease.
Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin Correa, Marco Romano, Silvia Cellone Trevelin, Robert I Lechler

EBioMedicine· September 2023

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Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with Zr-oxine for Medium-Term Cell Tracking.
Jacinta Jacob, Alessia Volpe, Qi Peng, Robert I Lechler, Lesley A Smyth

Molecules· February 2023

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Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival.
Qi Peng, Anna Nowocin, Kulachelvy Ratnasothy, Richard A Smith, Lesley A Smyth, Robert I Lechler

Front Immunol· February 2023

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Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
Yasmin R Mohseni, Adeel Saleem, Sim L Tung, Caroline Dudreuilh, Cameron Lang, Robert I Lechler

Eur J Immunol· October 2021

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Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance?
Niloufar Safinia, Trishan Vaikunthanathan, Robert Ian Lechler, Alberto Sanchez-Fueyo, Giovanna Lombardi

Eur J Immunol· October 2021

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Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency.
Silvia C Trevelin, Anna Zampetaki, Greta Sawyer, Aleksandar Ivetic, Alison C Brewer, Robert I Lechler

JCI Insight· September 2021

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Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients.
Marco Romano, Monica Sen, Cristiano Scottà, Rowa Y Alhabbab, Andres Rico-Armada, Robert I Lechler

Eur J Immunol· August 2021

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B lymphocytes contribute to indirect pathway T cell sensitization via acquisition of extracellular vesicles.
Pablo D Becker, Kulachelvy Ratnasothy, Monica Sen, Qi Peng, Marco Romano, Robert I Lechler

Am J Transplant· April 2021

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The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology.
Yasmin R Mohseni, Sim L Tung, Caroline Dudreuilh, Robert I Lechler, Gilbert O Fruhwirth

Front Immunol· April 2021

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Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients.
Paul N Harden, David S Game, Birgit Sawitzki, Jeroen B Van der Net, Joanna Hester, Robert I Lechler

Am J Transplant· April 2021

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PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.
Giorgia Fanelli, Marco Romano, Estefania Nova-Lamperti, Mariana Werner Sunderland, Alessandra Nerviani, Robert I Lechler

PLoS Biol· April 2021

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Spatiotemporal tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment.
Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L Tung, Robert I Lechler

Mol Ther Methods Clin Dev· March 2021

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Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.
Qi Peng, Kulachelvy Ratnasothy, Dominic A Boardman, Jacinta Jacob, Sim Lai Tung, Robert I Lechler

Front Immunol· October 2020

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Sustaining Translational Research.
Robert Lechler

Rambam Maimonides Med J· October 2020

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Translational Research in the Time of COVID-19-Dissolving Boundaries.
Jonathan D Edgeworth, Rahul Batra, Gaia Nebbia, Karen Bisnauthsing, Eithne MacMahon, Robert I Lechler

PLoS Pathog· September 2020

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Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy.
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Robert I Lechler

EBioMedicine· August 2020

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Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Birgit Sawitzki, Paul N Harden, Petra Reinke, Aurélie Moreau, James A Hutchinson, Robert I Lechler

Lancet· May 2020

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Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation.
Alberto Sánchez-Fueyo, Gavin Whitehouse, Nathali Grageda, Matthew E Cramp, Tiong Y Lim, Robert Lechler

Am J Transplant· April 2020

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Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress.
Adam G Laing, Giorgia Fanelli, Andrei Ramirez-Valdez, Robert I Lechler, Giovanna Lombardi

PLoS One· December 2019

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Regulatory B cells: Development, phenotypes, functions, and role in transplantation.
Rowa Y Alhabbab, Estefanía Nova-Lamperti, Octavio Aravena, Hannah M Burton, Robert I Lechler

Immunol Rev· November 2019

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IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival.
Kulachelvy Ratnasothy, Jacintha Jacob, Sim Tung, Dominic Boardman, Robert Ian Lechler

Am J Transplant· July 2019

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Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
Amber Emmerson, Silvia Cellone Trevelin, Heloise Mongue-Din, Pablo D Becker, Carla Ortiz, Robert I Lechler

J Clin Invest· July 2018

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Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells.
Marco Romano, Giorgia Fanelli, Nicole Tan, Estefania Nova-Lamperti, Reuben McGregor, Robert I Lechler

Front Immunol· July 2018

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Regulatory T cell-derived extracellular vesicles modify dendritic cell function.
Sim L Tung, Dominic A Boardman, Monica Sen, Marilena Letizia, Qi Peng, Robert Lechler

Sci Rep· April 2018

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A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.
Henrieta Fraser, Niloufar Safinia, Nathali Grageda, Sarah Thirkell, Katie Lowe, Robert I Lechler

Mol Ther Methods Clin Dev· March 2018

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