Publications by authors named "Robert Lefkowitz"

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A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia.
Alyssa Grogan, Robin M Perelli, Seungkirl Ahn, Haoran Jiang, Arun Jyothidasan, Robert J Lefkowitz

J Clin Invest· December 2025

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Tumor and Immune Dynamics Following Sequential CDK4/6 and PD-1 Inhibition: Results from a Phase 2 Study in Dedifferentiated Liposarcoma.
Evan Rosenbaum, Rodrigo Gularte-Mérida, Evan Seffar, Jasme Lee, Mathew Adamow, Robert A Lefkowitz

Cancer Res Commun· December 2025

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Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.
Natalia Pakharukova, Brittany N Thomas, Harsh Bansia, Linus Li, Dana K Bassford, Robert J Lefkowitz

bioRxiv· September 2025

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Clinicopathologic and Molecular Analysis of Primary Angiosarcoma of Bone-A Single Institution Experience.
Takeshi Hirose, Hsin-Yi Chang, Robert A Lefkowitz, John Healey, Cristina R Antonescu

Genes Chromosomes Cancer· June 2025

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Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma.
Sujana Movva, Kenneth Seier, Martina Bradic, Karmelina Charalambous, Evan Rosenbaum, Robert A Lefkowitz

J Immunother Cancer· June 2025

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Small-molecule modulation of β-arrestins.
Alem W Kahsai, Natalia Pakharukova, Henry Y Kwon, Kunal S Shah, Jason G Liang-Lin, Robert J Lefkowitz

bioRxiv· April 2025

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Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Marina Casiraghi, Haoqing Wang, Patrick C Brennan, Chris Habrian, Harald Hübner, Robert J Lefkowitz

Sci Adv· March 2025

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Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Marina Casiraghi, Haoqing Wang, Patrick Brennan, Chris Habrian, Harald Hubner, Robert J Lefkowitz

bioRxiv· January 2025

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Corrigendum to "Cabozantinib Plus Nivolumab in Patients with Non-Clear Cell Renal Cell Carcinoma: Updated Results from a Phase II Trial" [Eur. Urol. 86(2) (2024) 90-94].
Kelly N Fitzgerald, Chung-Han Lee, Martin H Voss, Maria I Carlo, Andrea Knezevic, Robert A Lefkowitz

Eur Urol· January 2025

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A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma-A Controversial and Pathologically Challenging Low-Grade Sarcoma.
Takeshi Hirose, Hsin-Yi Chang, Carla Saoud, Robert A Lefkowitz, Edward Athanasian

Genes Chromosomes Cancer· January 2025

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Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma.
Sujana Movva, Kenneth Seier, Viswatej Avutu, Lauren B Banks, Jason Chan, Robert A Lefkowitz

Clin Cancer Res· December 2024

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Cabozantinib Plus Nivolumab in Patients with Non-Clear Cell Renal Cell Carcinoma: Updated Results from a Phase 2 Trial.
Kelly N Fitzgerald, Chung-Han Lee, Martin H Voss, Maria I Carlo, Andrea Knezevic, Robert A Lefkowitz

Eur Urol· August 2024

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Reflections from Nobel laureates in chemistry.
Thomas R Cech, Emmanuelle Charpentier, Aaron Ciechanover, Robert J Lefkowitz, Kurt Wüthrich

Cell Chem Biol· August 2024

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G Protein-Coupled Receptors: A Century of Research and Discovery.
Samuel Liu, Preston J Anderson, Sudarshan Rajagopal, Robert J Lefkowitz, Howard A Rockman

Circ Res· June 2024

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G protein-coupled receptors: from radioligand binding to cellular signaling.
Howard A Rockman, Robert J Lefkowitz

J Clin Invest· March 2024

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Combined RAF and MEK Inhibition to Treat Activated Non-V600 BRAF-Altered Advanced Cancers.
Naryan Rustgi, Ann Maria, Nicolas Toumbacaris, HuiYong Zhao, Katherine Kargus, Robert A Lefkowitz

Oncologist· January 2024

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How carvedilol does not activate β-adrenoceptors.
Robert J Lefkowitz, Howard A Rockman, Paul J Shim, Samuel Liu, Seungkirl Ahn

Nat Commun· November 2023

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Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin.
Alem W Kahsai, Kunal S Shah, Paul J Shim, Mason A Lee, Bowie N Shreiber, Robert J Lefkowitz

Proc Natl Acad Sci U S A· October 2023

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Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models.
Seungkirl Ahn, Harm Maarsingh, Julia Kl Walker, Samuel Liu, Akhil Hegde, Robert J Lefkowitz

J Clin Invest· September 2023

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Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.
Angus Li, Samuel Liu, Rennica Huang, Seungkirl Ahn, Robert J Lefkowitz

PLoS One· March 2023

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Marc G. Caron (1946-2022).
Robert J Lefkowitz, Susan G Amara

Nat Neurosci· September 2022

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MRI-Detectability of Clinically Significant Prostate Cancer Relates to Oncologic Outcomes After Prostatectomy.
Andreas G Wibmer, Robert A Lefkowitz, Yulia Lakhman, Joshua Chaim, Ines Nikolovski

Clin Genitourin Cancer· August 2022

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Phase II Trial of Cabozantinib Plus Nivolumab in Patients With Non-Clear-Cell Renal Cell Carcinoma and Genomic Correlates.
Chung-Han Lee, Martin H Voss, Maria Isabel Carlo, Ying-Bei Chen, Mark Zucker, Robert A Lefkowitz

J Clin Oncol· July 2022

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Standardized Reporting of Oncologic Response: Making Every Report Count.
Richard K G Do, Robert A Lefkowitz, Vaios Hatzoglou, Weining Ma, Krishna Juluru

Radiol Imaging Cancer· June 2022

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GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
Wesley B Asher, Daniel S Terry, G Glenn A Gregorio, Alem W Kahsai, Alessandro Borgia, Robert J Lefkowitz

Cell· May 2022

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