Publications by authors named "Robert Martone"

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Combining Lumipulse p-tau217 and Aβ42/40 as confirmatory tests for Aβ positivity prior to disease-modifying therapy.
James D Doecke, Ahmed Chenna, Mintzu Lo, Youssouf Badal, Brandon Yee, Robert Martone

Alzheimers Dement· September 2025

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Dementia Can Unleash Creativity: Frontotemporal dementia can release the creative potential of the brain's visual areas.
Robert Martone

Sci Am· September 2023

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CSF biomarker concordance with amyloid PET in Phase 3 studies of aducanumab.
Laura Nisenbaum, Robert Martone, Tianle Chen, Rajasimhan Rajagovindan, Gersham Dent

Alzheimers Dement· August 2023

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Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity.
Stephen Zicha, Randall J Bateman, Leslie M Shaw, Henrik Zetterberg, Anthony W Bannon, Robert L Martone

Alzheimers Dement· March 2023

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How Our Brain Preserves Our Sense of Self: One brain region is crucial for our ability to form and maintain a consistent identity both now and when thinking about the future.
Robert Martone

Sci Am· August 2022

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Critical Need for Inclusion of Under-Served Minorities in the Emerging Clinical Landscape for Alzheimer's Disease.
Robert Martone, John R Shook

AJOB Neurosci· November 2021

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Ethical and Regulatory Concerns About Direct-to-Consumer Brain Stimulation for Athletic Enhancement.
Robert Martone, John Shook

AJOB Neurosci· March 2020

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Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.
Niklas Mattsson, Ingrid Zegers, Ulf Andreasson, Maria Bjerke, Marinus A Blankenstein, Robert L Martone

Biomark Med· August 2012

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Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
H Beal McIlvain, Linh Ma, Brian Ludwig, Melissa T Manners, Robert L Martone

Eur J Pharmacol· September 2010

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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Robert L Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z Xu

J Pharmacol Exp Ther· November 2009

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Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.
Anthony F Kreft, Robert Martone, Alexander Porte

J Med Chem· October 2009

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Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Jun Pu, Anthony F Kreft, Suzan H Aschmies, Kevin P Atchison, Joshua Berkowitz, Robert L Martone

Bioorg Med Chem· July 2009

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(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Derek C Cole, Joseph R Stock, Anthony F Kreft, Madelene Antane, Suzan H Aschmies, Robert L Martone

Bioorg Med Chem Lett· February 2009

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Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Scott C Mayer, Anthony F Kreft, Boyd Harrison, Magid Abou-Gharbia, Madelene Antane, Robert Martone

J Med Chem· December 2008

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Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
Anthony Kreft, Boyd Harrison, Suzan Aschmies, Kevin Atchison, David Casebier, Robert Martone

Bioorg Med Chem Lett· July 2008

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Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
J Steven Jacobsen, Thomas A Comery, Robert L Martone, Hassan Elokdah, David L Crandall

Proc Natl Acad Sci U S A· June 2008

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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
David R Riddell, Hua Zhou, Thomas A Comery, Evguenia Kouranova, C Frederick Lo, Robert L Martone

Mol Cell Neurosci· April 2007

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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.
J Steven Jacobsen, Chi-Cheng Wu, Jeffrey M Redwine, Thomas A Comery, Robert Arias, Robert Martone

Proc Natl Acad Sci U S A· March 2006

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
Thomas A Comery, Robert L Martone, Suzan Aschmies, Kevin P Atchison, George Diamantidis

J Neurosci· September 2005

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Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.
Eric Gundersen, Kristi Fan, Kimberly Haas, Donna Huryn, J Steven Jacobsen, Robert Martone

Bioorg Med Chem Lett· April 2005

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