Publications by authors named "Robert Signer"

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Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia.
Fanny J Zhou, Michelle K Le, Helen C Wang, Wei Yang, Huan-You Wang, Robert A J Signer

bioRxiv· December 2025

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The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia.
Kentson Lam, Yoon Joon Kim, Evelyn Li-Ting Tan, Carlo Miguel Ong, Andrea Zoey Liu, Robert Signer

Blood· October 2025

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RPS19 and RPL5 Haploinsufficient Models Reveal Divergent Ribosomal Subunit Controls of Fetal Hematopoiesis.
Lionel Blanc, Yuefeng Tang, Te Ling, Rashid Mehmood, Alexis Bertrand, Robert Signer

Res Sq· September 2025

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Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis.
Eleanor I Sams, Victoria K Feist, Erin M Gray, Subin S George, Charles Antony, Robert A J Signer

bioRxiv· August 2025

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Proteostasis disruption in inherited bone marrow failure syndromes.
Helena Yu, Robert A J Signer

Blood· July 2025

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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress.
Kevin Rhine, Rachel Li, Hema M Kopalle, Katherine Rothamel, Xuezhen Ge, Robert A J Signer

Nat Neurosci· June 2025

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Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells.
Luana Chiquetto, Meg Schuetz, Qian Dong, Mia Warmka, Liana Valin, Robert A J Signer

bioRxiv· March 2025

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Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice.
Isabelle C Becker, Maria N Barrachina, Joshua Lykins, Virginia Camacho, Andrew P Stone, Robert A J Signer

bioRxiv· December 2024

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The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia.
Kentson Lam, Yoon Joon Kim, Carlo M Ong, Andrea Z Liu, Fanny J Zhou, Robert A J Signer

bioRxiv· September 2024

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Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway.
Cuiping Zhang, Xiaojing Cui, Yi Liu, Fang Wang, Robert Signer

Haematologica· December 2023

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis.
Bernadette A Chua, Connor J Lennan, Mary Jean Sunshine, Daniela Dreifke, Ashu Chawla, Robert A J Signer

Cell Stem Cell· April 2023

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Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification.
Grant A Challen, Eric M Pietras, Nina Cabezas Wallscheid, Robert A J Signer

Exp Hematol· December 2021

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Miriama Kruta, Mary Jean Sunshine, Bernadette A Chua, Yunpeng Fu, Ashu Chawla, Robert A J Signer

Cell Stem Cell· November 2021

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Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis.
Jeffrey A Magee, Robert A J Signer

Stem Cell Reports· January 2021

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ERADicating stem cells from their niche.
Kentson Lam, Robert A J Signer

Nat Cell Biol· October 2020

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Hematopoietic stem cell regulation by the proteostasis network.
Bernadette A Chua, Robert A J Signer

Curr Opin Hematol· July 2020

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Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells.
Bernadette A Chua, Inge Van Der Werf, Catriona Jamieson, Robert A J Signer

Cell Stem Cell· February 2020

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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H Dillingham, Bernadette A Chua, Miriama Kruta, Robert A J Signer

Cell Rep· January 2020

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Cell-type-specific quantification of protein synthesis in vivo.
Lorena Hidalgo San Jose, Robert A J Signer

Nat Protoc· February 2019

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Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells.
Miriama Kruta, Robert A J Signer

Cell Stem Cell· March 2018

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CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.
Nadia T Sebastian, Thomas D Zaikos, Valeri Terry, Frances Taschuk, Lucy A McNamara, Robert A J Signer

PLoS Pathog· July 2017

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Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A J Signer

Nat Cell Biol· June 2017

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Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function.
Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Robert A J Signer

Nature· January 2017

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Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.
Victoria E Mgbemena, Robert A J Signer, Ranjula Wijayatunge, Travis Laxson, Sean J Morrison

Cell Rep· January 2017

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