Publications by authors named "Robin D Couch"

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Inhibition of DXR in the MEP pathway with lipophilic -alkoxyaryl FR900098 analogs.
Darean Bague, Ruiqin Wang, Dana Hodge, Marwa O Mikati, Jose S Roma, Robin D Couch

RSC Med Chem· July 2024

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MEPicides: α,β-unsaturated Fosmidomycin -Acyl Analogs as Efficient Inhibitors of 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
Xu Wang, Rachel L Edwards, Haley S Ball, Kenneth M Heidel, Robert C Brothers, Robin D Couch

ACS Infect Dis· July 2023

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LC-QToF-Based Metabolomics Identifies Aberrant Tissue Metabolites Associated with a Higher-Fat Diet and Their 'Reversion to Healthy' with Dietary Probiotic Supplementation.
Allyson Dailey, Gloria Solano-Aguilar, Joseph F Urban, Robin D Couch

Metabolites· February 2023

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Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in and .
Haley S Ball, Misgina B Girma, Mosufa Zainab, Iswarduth Soojhawon, Robin D Couch

ACS Infect Dis· November 2021

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Mechanism of Action of -Acyl and -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from , a Causative Agent of Malaria.
Misgina B Girma, Haley S Ball, Xu Wang, Robert C Brothers, Emily R Jackson, Robin D Couch

ACS Omega· October 2021

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Inhibition of the Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues.
Haley S Ball, Misgina Girma, Mosufa Zainab, Honoria Riley, Christoph T Behrendt, Robin D Couch

ACS Omega· March 2020

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MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Xu Wang, Rachel L Edwards, Haley Ball, Claire Johnson, Amanda Haymond, Robin D Couch

J Med Chem· October 2018

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A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).
Amanda Haymond, Tyrone Dowdy, Chinchu Johny, Claire Johnson, Haley Ball, Robin D Couch

Anal Biochem· February 2018

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Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.
Géraldine San Jose, Emily R Jackson, Amanda Haymond, Chinchu Johny, Rachel L Edwards, Robin D Couch

ACS Infect Dis· December 2016

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Alcohol induced alterations to the human fecal VOC metabolome.
Robin D Couch, Allyson Dailey, Fatima Zaidi, Karl Navarro, Christopher B Forsyth

PLoS One· January 2016

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Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Robin D Couch

PLoS One· November 2015

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Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
René Chofor, Sanjeewani Sooriyaarachchi, Martijn D P Risseeuw, Terese Bergfors, Jenny Pouyez, Robin D Couch

J Med Chem· April 2015

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The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome.
Robin D Couch, Karl Navarro, Masoumeh Sikaroodi, Pat Gillevet, Christopher B Forsyth

PLoS One· June 2014

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Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.
René Chofor, Martijn D P Risseeuw, Jenny Pouyez, Chinchu Johny, Johan Wouters, Robin D Couch

Molecules· February 2014

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The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.
Emily R Jackson, Géraldine San Jose, Robert C Brothers, Emma K Edelstein, Zachary Sheldon, Robin D Couch

Bioorg Med Chem Lett· January 2014

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Design of Potential Bisubstrate Inhibitors against (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.
Géraldine San Jose, Emily R Jackson, Eugene Uh, Chinchu Johny, Amanda Haymond, Robin D Couch

Medchemcomm· July 2013

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Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Robin D Couch

PLoS One· March 2013

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Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis.
Robert W Li, Sitao Wu, Weizhong Li, Karl Navarro, Robin D Couch

Infect Immun· June 2012

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Personalized medicine: changing the paradigm of drug development.
Robin D Couch, Bryan T Mott

Methods Mol Biol· April 2012

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Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation.
Arthur Tsang, Heather Seidle, Safdar Jawaid, Weidong Zhou, Clint Smith, Robin D Couch

PLoS One· October 2011

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Bacteria-induced static batch fungal fermentation of the diterpenoid cyathin A(3), a small-molecule inducer of nerve growth factor.
Emma Dixon, Tatiana Schweibenz, Alison Hight, Brian Kang, Allyson Dailey, Robin D Couch

J Ind Microbiol Biotechnol· May 2011

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Solid-phase microextraction and the human fecal VOC metabolome.
Emma Dixon, Cynthia Clubb, Sara Pittman, Larry Ammann, Zeehasham Rasheed, Robin D Couch

PLoS One· April 2011

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Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.
Safdar Jawaid, Monica Gertz, Carlin Corsino, Jamie Cheung, Heather Seidle, Robin D Couch

Indian J Biochem Biophys· December 2010

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Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).
Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Robin D Couch

PLoS One· December 2009

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Characterization of a nonspecific phosphopantetheinyl transferase from Pseudomonas syringae pv. syringae FF5.
Heather F Seidle, Robin D Couch, Ronald J Parry

Arch Biochem Biophys· February 2006

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