Publications by authors named "Robyn Meech"

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Sex-specific UGT expression and function: prevalence, potential mechanisms and significance.
Robyn Meech, Dong Gui Hu, Julie-Ann Hulin, Peter I Mackenzie

Expert Opin Drug Metab Toxicol· May 2025

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Activation of Cryptic Donor Splice Sites within the UDP-Glucuronosyltransferase (UGT)1A First-Exon Region Generates Variant Transcripts That Encode UGT1A Proteins with Truncated Aglycone-Binding Domains.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Radwan Ansaar, Peter I Mackenzie, Robyn Meech

Drug Metab Dispos· May 2024

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A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A McKinnon, Peter I Mackenzie, Robyn Meech

Cancers (Basel)· January 2024

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Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance.
John O Miners, Thomas M Polasek, Julie-Ann Hulin, Andrew Rowland, Robyn Meech

Pharmacol Ther· August 2023

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A Physiologically Based Pharmacokinetic Model to Predict Determinants of Variability in Epirubicin Exposure and Tissue Distribution.
Radwan Ansaar, Robyn Meech, Andrew Rowland

Pharmaceutics· April 2023

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Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation.
Emma N Finburgh, Olivier Mauduit, Takako Noguchi, Jennifer J Bu, Anser A Abbas, Robyn Meech

Invest Ophthalmol Vis Sci· January 2023

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Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells.
Saira R Ali, Karen J Humphreys, Kaylene J Simpson, Ross A McKinnon, Robyn Meech

Mol Ther Nucleic Acids· December 2022

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The Somatic Mutation Landscape of UDP-Glycosyltransferase () Genes in Human Cancers.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A McKinnon, Peter I Mackenzie, Robyn Meech

Cancers (Basel)· November 2022

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Regulation of human UDP-glycosyltransferase () genes by miRNAs.
Dong Gui Hu, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon, Robyn Meech

Drug Metab Rev· May 2022

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Pannexin 1 Regulates Skeletal Muscle Regeneration by Promoting Bleb-Based Myoblast Migration and Fusion Through a Novel Lipid Based Signaling Mechanism.
Katia Suarez-Berumen, Henry Collins-Hooper, Anastasia Gromova, Robyn Meech, Alessandra Sacco

Front Cell Dev Biol· October 2021

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The Expression Profiles and Deregulation of UDP-Glycosyltransferase () Genes in Human Cancers and Their Association with Clinical Outcomes.
Dong Gui Hu, Shashikanth Marri, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon, Robyn Meech

Cancers (Basel)· September 2021

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Circular RNAs of UDP-Glycosyltransferase () Genes Expand the Complexity and Diversity of the UGT Transcriptome.
Dong Gui Hu, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon, Robyn Meech

Mol Pharmacol· June 2021

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Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres.
Olga A Sukocheva, Dong Gui Hu, Robyn Meech, Anupam Bishayee

Int J Mol Sci· April 2021

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Integrative Transcriptomic Network Analysis of Butyrate Treated Colorectal Cancer Cells.
Saira R Ali, Ayla Orang, Shashikanth Marri, Ross A McKinnon, Robyn Meech

Cancers (Basel)· February 2021

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The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
Dong Gui Hu, Peter I Mackenzie, Pramod C Nair, Ross A McKinnon, Robyn Meech

Cancers (Basel)· November 2020

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The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism.
Dong Gui Hu, J Ulie-Ann Hulin, Pramod C Nair, Alex Z Haines, Ross A McKinnon, Robyn Meech

Pharmacol Ther· December 2019

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Wnt/β-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program.
Shuang Cui, Liang Li, Siti Nurul Mubarokah, Robyn Meech

J Cell Biochem· August 2019

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Isolation and Propagation of Lacrimal Gland Putative Epithelial Progenitor Cells.
Helen P Makarenkova, Robyn Meech

Methods Mol Biol· July 2019

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The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.
Robyn Meech, Dong Gui Hu, Ross A McKinnon, Siti Nurul Mubarokah, Alex Z Haines

Physiol Rev· April 2019

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Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma.
Dong Gui Hu, Shashikanth Marri, Ross A McKinnon, Peter I Mackenzie, Robyn Meech

J Pharmacol Exp Ther· March 2019

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β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.
Shuang Cui, Liang Li, Ruth T Yu, Michael Downes, Ronald M Evans, Robyn Meech

Development· March 2019

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Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.
Andrew Rowland, Warit Ruanglertboon, Madelé van Dyk, Dhilushi Wijayakumara, Linda S Wood, Robyn Meech

Br J Clin Pharmacol· January 2019

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Intergenic Splicing between Four Adjacent Genes () Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.
Dong Gui Hu, Julie-Ann Hulin, Dhilushi D Wijayakumara, Ross A McKinnon, Peter I Mackenzie, Robyn Meech

Mol Pharmacol· September 2018

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Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4 Is Mediated by a Novel Composite Regulatory Element.
Nurul Mubarokah, Julie-Ann Hulin, Peter I Mackenzie, Ross A McKinnon, Alex Z Haines, Robyn Meech

Mol Pharmacol· May 2018

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Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites.
Dhilushi D Wijayakumara, Peter I Mackenzie, Ross A McKinnon, Dong Gui Hu, Robyn Meech

J Pharmacol Exp Ther· April 2018

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