Publications by authors named "Rock Breton"

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Enzymatic activity of Lecithin:retinol acyltransferase: a thermostable and highly active enzyme with a likely mode of interfacial activation.
Habib Horchani, Sylvain Bussières, Line Cantin, Mustapha Lhor, Jean-Sébastien Laliberté-Gemme, Rock Breton

Biochim Biophys Acta· June 2014

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Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition.
Frédérick Faucher, Line Cantin, Van Luu-The, Fernand Labrie, Rock Breton

Biochemistry· December 2008

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The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Frédérick Faucher, Line Cantin, Van Luu-The, Fernand Labrie, Rock Breton

Biochemistry· August 2008

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Secondary structure of a truncated form of lecithin retinol acyltransferase in solution and evidence for its binding and hydrolytic action in monolayers.
Sylvain Bussières, Thierry Buffeteau, Bernard Desbat, Rock Breton, Christian Salesse

Biochim Biophys Acta· May 2008

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Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
Line Cantin, Frédérick Faucher, Jean-François Couture, Karine Pereira de Jésus-Tran, Pierre Legrand, Rock Breton

J Biol Chem· October 2007

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Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
Frédérick Faucher, Line Cantin, Karine Pereira de Jésus-Tran, Mélanie Lemieux, Van Luu-The, Rock Breton

J Mol Biol· June 2007

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Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.
Jenny Roy, Rock Breton, Céline Martel, Fernand Labrie, Donald Poirier

Bioorg Med Chem· April 2007

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Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.
Frédérick Faucher, Karine Pereira de Jésus-Tran, Line Cantin, Van Luu-The, Fernand Labrie, Rock Breton

J Mol Biol· December 2006

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Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Karine Pereira de Jésus-Tran, Pierre-Luc Côté, Line Cantin, Jonathan Blanchet, Fernand Labrie, Rock Breton

Protein Sci· May 2006

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Binding of RPE65 fragments to lipid monolayers and identification of its partners by glutathione S-transferase pull-down assays.
Eric Trudel, Sylvie Beaufils, Anne Renault, Rock Breton, Christian Salesse

Biochemistry· March 2006

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Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.
Véronique Bellemare, Frédérick Faucher, Rock Breton, Van Luu-The

BMC Biochem· July 2005

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Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
Jean-François Couture, Karine Pereira de Jésus-Tran, Anne-Marie Roy, Line Cantin, Pierre-Luc Côté, Rock Breton

Protein Sci· June 2005

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Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
Martine Dumont, David Frank, Anne-Marie Moisan, Martine Tranchant, Penny Soucy, Rock Breton

Biochim Biophys Acta· September 2004

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Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
Jean-François Couture, Pierre Legrand, Line Cantin, Fernand Labrie, Van Luu-The, Rock Breton

J Mol Biol· May 2004

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The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.
Manon Richard, Nathalie Thibault, Patricia Veilleux, Rock Breton, André D Beaulieu

Biochem Biophys Res Commun· October 2003

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Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
Jean-François Couture, Pierre Legrand, Line Cantin, Van Luu-The, Fernand Labrie, Rock Breton

J Mol Biol· August 2003

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Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates.
Jean François Couture, Line Cantin, Pierre Legrand, Van Luu-The, Fernand Labrie, Rock Breton

Acta Crystallogr D Biol Crystallogr· January 2002

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