Publications by authors named "Roderick Beijersbergen"

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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.
Rachele Niccolai, Camiel Göbel, Klevis Ndoj, Maaike Kreft, Hendrik J Kuiken, Roderick L Beijersbergen

Neoplasia· December 2025

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Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models.
Adva Kochavi, Arno Velds, Maya Suzuki, Shinichiro Akichika, Tsutomu Suzuki, Roderick L Beijersbergen

NAR Cancer· December 2025

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Inducible CRISPR-Cas9 screening platform to interrogate non-proliferative cellular states.
Gabriele Casagrande Raffi, Hendrik J Kuiken, Cor Lieftink, Rene Bernards, Roderick L Beijersbergen

Nat Protoc· October 2025

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CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma.
Wu Yang, Siying Wang, Shuyi Ji, Jian Wang, Shuo Lian, Roderick L Beijersbergen

Proc Natl Acad Sci U S A· September 2025

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Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.
Tesa M Severson, Emma Minnee, Yanyun Zhu, Karianne Schuurman, Holly M Nguyen, Roderick L Beijersbergen

Cell Rep Med· July 2025

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A functionally validated TCR-pMHC database for TCR specificity model development.
Marius Messemaker, Bjørn P Y Kwee, Živa Moravec, Daniel Álvarez-Salmoral, Jos Urbanus, Roderick L Beijersbergen

bioRxiv· May 2025

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An antibiotic that mediates immune destruction of senescent cancer cells.
Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng, Zhen Chen, Cor Lieftink, Roderick Beijersbergen

Proc Natl Acad Sci U S A· December 2024

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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.
Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Roderick L Beijersbergen

Genome Biol· December 2024

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P-stalk ribosomes act as master regulators of cytokine-mediated processes.
Anna Dopler, Ferhat Alkan, Yuval Malka, Rob van der Kammen, Kelly Hoefakker, Roderick Beijersbergen

Cell· November 2024

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ADARp150 counteracts whole genome duplication.
Frank van Gemert, Alexandra Drakaki, Isabel Morales Lozano, Daniël de Groot, Maud Schoot Uiterkamp, Roderick L Beijersbergen

Nucleic Acids Res· September 2024

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Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing.
Ruben Schep, Max Trauernicht, Xabier Vergara, Anoek Friskes, Ben Morris, Roderick L Beijersbergen

Nucleic Acids Res· August 2024

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Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy.
Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M Fernandes Neto, Frank van Gemert, Roderick L Beijersbergen

Cancer Discov· July 2024

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Widespread chromatin context-dependencies of DNA double-strand break repair proteins.
Xabier Vergara, Anna G Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Roderick L Beijersbergen

Nat Commun· June 2024

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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.
Christina Andronikou, Kamila Burdova, Diego Dibitetto, Cor Lieftink, Elke Malzer, Roderick L Beijersbergen

EMBO J· March 2024

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Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity.
Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Roderick Beijersbergen

EMBO Mol Med· December 2023

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Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.
Maria Elize van Breugel, Ila van Kruijsbergen, Chitvan Mittal, Cor Lieftink, Ineke Brouwer, Roderick L Beijersbergen

Mol Cell· December 2023

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PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.
Isabel Mayayo-Peralta, Sebastian Gregoricchio, Karianne Schuurman, Selçuk Yavuz, Anniek Zaalberg, Roderick L Beijersbergen

Nucleic Acids Res· October 2023

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A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator.
Anniek Zaalberg, Emma Minnee, Isabel Mayayo-Peralta, Karianne Schuurman, Sebastian Gregoricchio, Roderick L Beijersbergen

bioRxiv· June 2023

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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors.
Vera E van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J Kuiken, Roderick L Beijersbergen

Breast Cancer Res· May 2023

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors.
Jinhyuk Bhin, Mariana Paes Dias, Ewa Gogola, Frank Rolfs, Sander R Piersma, Roderick L Beijersbergen

Cell Rep· May 2023

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Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells.
Esmée P Hoefsmit, Paula T van Royen, Disha Rao, Johanna A Stunnenberg, P Dimitriadis, Roderick L Beijersbergen

Cancer Immunol Res· April 2023

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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer.
Joyce Y Buikhuisen, Patricia M Gomez Barila, Kate Cameron, Saskia J E Suijkerbuijk, Cor Lieftink, Roderick L Beijersbergen

J Exp Clin Cancer Res· March 2023

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Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients.
Tesa M Severson, Yanyun Zhu, Stefan Prekovic, Karianne Schuurman, Holly M Nguyen, Roderick L Beijersbergen

medRxiv· February 2023

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Mammalian life depends on two distinct pathways of DNA damage tolerance.
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Roderick L Beijersbergen

Proc Natl Acad Sci U S A· January 2023

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