Publications by authors named "Roger B Clark"

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A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer.
Esteban Terzo, Shruti A Apte, Simran Padhye, Saleh Rashed, Wesley Austin, Roger B Clark

Cancer Res Commun· June 2023

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Novel read through agent: ZKN-0013 demonstrates efficacy in APC model of familial adenomatous polyposis.
Martin R Graf, Shruti Apte, Esteban Terzo, Simran Padhye, Shuhao Shi, Roger B Clark

J Mol Med (Berl)· April 2023

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Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens.
Andrew G Myers, Roger B Clark

Acc Chem Res· April 2021

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Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens.
Cuixiang Sun, Yonghong Deng, Diana K Hunt, Corey Fyfe, Chi-Li Chen, Roger B Clark

J Antibiot (Tokyo)· February 2018

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Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents.
Cuixiang Sun, Diana K Hunt, Chi-Li Chen, Yonghong Deng, Minsheng He, Roger B Clark

J Med Chem· June 2015

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Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.
Roger B Clark, Diana Lamppu, Lyn Libertine, Amy McDonough, Anjali Kumar

J Med Chem· May 2014

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Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents.
Roger B Clark, Minsheng He, Yonghong Deng, Cuixiang Sun, Chi-Li Chen

J Med Chem· October 2013

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Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent.
Xiao-Yi Xiao, Diana K Hunt, Jingye Zhou, Roger B Clark, Nick Dunwoody

J Med Chem· January 2012

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Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy.
Roger B Clark, Diana K Hunt, Minsheng He, Catherine Achorn, Chi-Li Chen

J Med Chem· January 2012

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Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs.
Cuixiang Sun, Diana K Hunt, Roger B Clark, Denene Lofland, William J O'Brien

J Med Chem· June 2011

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8-Azatetracyclines: synthesis and evaluation of a novel class of tetracycline antibacterial agents.
Roger B Clark, Minsheng He, Corey Fyfe, Denene Lofland, William J O'Brien

J Med Chem· March 2011

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