Publications by authors named "Roger D Cone"

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An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist.
Stephen T Joy, Naima S Dahir, Roger D Cone, Anna K Mapp

Pept Sci (Hoboken)· January 2025

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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice.
Naima S Dahir, Yijun Gui, Yanan Wu, Patrick R Sweeney, Alix Aj Rouault, Roger D Cone

J Clin Invest· July 2024

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Automated Patch Clamp Recordings of GPCR-Gated Ion Channels: Targeting the MC4-R/Kir7.1 Potassium Channel Complex.
Ciria C Hernandez, Luis E Gimenez, Roger D Cone

Methods Mol Biol· June 2024

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Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia.
Li Li, Ciria C Hernandez, Luis E Gimenez, Baijie Xu, Naima S Dahir, Roger D Cone

bioRxiv· June 2024

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Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States.
Alys Peisley, Ciria C Hernandez, Naima S Dahir, Laura Koepping, Ashleigh Raczkowski, Roger D Cone

bioRxiv· June 2024

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Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Luis E Gimenez, Charlotte Martin, Jing Yu, Charlie Hollanders, Ciria C Hernandez, Roger D Cone

J Med Chem· February 2024

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Aqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment.
Shuying Wang, Griffin Downing, Karl F Olsen, Tomi K Sawyer, Roger D Cone

J Control Release· December 2023

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Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.
Naima S Dahir, Yijun Gui, Yanan Wu, Patrick R Sweeney, Savannah Y Williams, Roger D Cone

bioRxiv· December 2023

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Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
Yijun Gui, Naima S Dahir, Yanan Wu, Griffin Downing, Patrick Sweeney, Roger D Cone

Cell Rep· October 2023

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Targeting the central melanocortin system for the treatment of metabolic disorders.
Patrick Sweeney, Luis E Gimenez, Ciria C Hernandez, Roger D Cone

Nat Rev Endocrinol· September 2023

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Cell autonomous regulation of the activation of AgRP neurons by the melanocortin-3 receptor.
Yijun Gui, Naima S Dahir, Griffin Downing, Patrick Sweeney, Roger D Cone

bioRxiv· June 2023

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Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis.
Zehong Wei, Amrutha Bagivalu Lakshminarasimha, Roger D Cone, Maximilian Michel

Gen Comp Endocrinol· May 2023

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The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control.
Ciria C Hernandez, Luis E Gimenez, Naima S Dahir, Alys Peisley, Roger D Cone

Am J Physiol Cell Physiol· March 2023

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Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
Michelle N Bedenbaugh, Samantha C Brener, Jose Maldonado, Rachel N Lippert, Patrick Sweeney, Roger D Cone

J Comp Neurol· November 2022

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Common Genetic Variation and Age of Onset of Anorexia Nervosa.
Hunna J Watson, Laura M Thornton, Zeynep Yilmaz, Jessica H Baker, Jonathan R I Coleman, Roger D Cone

Biol Psychiatry Glob Open Sci· October 2022

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Improved Growth and High Inheritance of Melanocortin-4 Receptor (mc4r) Mutation in CRISPR/Cas-9 Gene-Edited Channel Catfish, Ictalurus punctatus.
Michael Coogan, Veronica Alston, Baofeng Su, Karim Khalil, Ahmed Elaswad, Roger D Cone

Mar Biotechnol (NY)· October 2022

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Demonstration of a Common DPhe to DNal(2') Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.
Luis E Gimenez, Terry A Noblin, Savannah Y Williams, Satarupa Mullick Bagchi, Ren-Lei Ji, Roger D Cone

J Med Chem· April 2022

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Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.
Işın Çakır, Colleen K Hadley, Pauline Lining Pan, Rushita A Bagchi, Masoud Ghamari-Langroudi, Roger D Cone

Nat Metab· January 2022

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Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome.
Qiuyu Wang, Peng Zhang, Isin Cakir, Lin Mi, Roger D Cone

Diabetes· September 2021

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Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System.
Lia Puder, Sophie Roth, Philipp Krabusch, Susanna Wiegand, Robert Opitz, Roger D Cone

J Clin Endocrinol Metab· August 2021

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Network dynamics of hypothalamic feeding neurons.
Patrick Sweeney, Can Chen, Indika Rajapakse, Roger D Cone

Proc Natl Acad Sci U S A· April 2021

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The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
Patrick Sweeney, Michelle N Bedenbaugh, Jose Maldonado, Pauline Pan, Katelyn Fowler, Roger D Cone

Sci Transl Med· April 2021

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Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.
Charlotte Martin, Luis E Gimenez, Savannah Y Williams, Yu Jing, Yiran Wu, Roger D Cone

J Med Chem· January 2021

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Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.
Valerie Chen, Antonio E Bruno, Laura L Britt, Ciria C Hernandez, Luis E Gimenez, Roger D Cone

J Biol Chem· November 2020

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Determination of the melanocortin-4 receptor structure identifies Ca as a cofactor for ligand binding.
Jing Yu, Luis E Gimenez, Ciria C Hernandez, Yiran Wu, Ariel H Wein, Roger D Cone

Science· April 2020

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