Publications by authors named "Roland Stragies"

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Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch.
Andreas O Frank, Elke Otto, Carlos Mas-Moruno, Herbert B Schiller, Luciana Marinelli, Roland Stragies

Angew Chem Int Ed Engl· November 2010

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Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment.
Grit Zahn, Kristine Volk, Geoffrey P Lewis, Dörte Vossmeyer, Roland Stragies

Invest Ophthalmol Vis Sci· February 2010

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Novel small molecule bradykinin B1 receptor antagonists. Part 1: benzamides and semicarbazides.
Marco Schaudt, Elsa Locardi, Gunther Zischinsky, Roland Stragies, Jochen R Pfeifer

Bioorg Med Chem Lett· February 2010

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Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles.
Gunther Zischinsky, Roland Stragies, Marco Schaudt, Jochen R Pfeifer, Christoph Gibson

Bioorg Med Chem Lett· February 2010

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Novel small molecule bradykinin B1 receptor antagonists. Part 3: hydroxyurea derivatives.
Karsten Schnatbaum, Marco Schaudt, Roland Stragies, Jochen R Pfeifer, Christoph Gibson

Bioorg Med Chem Lett· February 2010

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Discovery of orally available integrin alpha5beta1 antagonists.
Gunther Zischinsky, Frank Osterkamp, Doerte Vossmeyer, Grit Zahn, Dirk Scharn, Roland Stragies

Bioorg Med Chem Lett· January 2010

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SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.
Gunther Zischinsky, Frank Osterkamp, Doerte Vossmeyer, Grit Zahn, Dirk Scharn, Roland Stragies

Bioorg Med Chem Lett· January 2010

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Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.
Grit Zahn, Dörte Vossmeyer, Roland Stragies, Margaret Wills, Corinne G Wong

Arch Ophthalmol· October 2009

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Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity.
Dominik Heckmann, Burkhardt Laufer, Luciana Marinelli, Vittorio Limongelli, Ettore Novellino, Roland Stragies

Angew Chem Int Ed Engl· September 2009

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An alpha5beta1 integrin inhibitor attenuates glioma growth.
Katrin Färber, Michael Synowitz, Grit Zahn, Dörte Vossmeyer, Roland Stragies

Mol Cell Neurosci· December 2008

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Rational design of highly active and selective ligands for the alpha5beta1 integrin receptor.
Dominik Heckmann, Axel Meyer, Burkhardt Laufer, Grit Zahn, Roland Stragies

Chembiochem· June 2008

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The role of integrin alpha5beta1 in the regulation of corneal neovascularization.
Philipp S Muether, Susanne Dell, Norbert Kociok, Grit Zahn, Roland Stragies

Exp Eye Res· September 2007

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Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule.
Anna-Karina B Maier, Norbert Kociok, Grit Zahn, Dörte Vossmeyer, Roland Stragies

Curr Eye Res· September 2007

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Design and synthesis of a new class of selective integrin alpha5beta1 antagonists.
Roland Stragies, Frank Osterkamp, Gunther Zischinsky, Doerte Vossmeyer, Holger Kalkhof

J Med Chem· August 2007

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Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor.
Dominik Heckmann, Axel Meyer, Luciana Marinelli, Grit Zahn, Roland Stragies

Angew Chem Int Ed Engl· July 2007

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Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade.
Tina Dietrich, Jasmine Onderka, Felix Bock, Friedrich E Kruse, Dörte Vossmeyer, Roland Stragies

Am J Pathol· July 2007

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Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist.
Naoyasu Umeda, Shu Kachi, Hideo Akiyama, Grit Zahn, Doerte Vossmeyer, Roland Stragies

Mol Pharmacol· June 2006

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Remote chirality transfer in nucleophilic catalysis with N-(4-pyridinyl)-L-proline derivatives.
Takeo Kawabata, Roland Stragies, Takayuki Fukaya, Kaoru Fuji

Chirality· January 2003

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