Publications by authors named "Ron A A Mathot"

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Pharmacokinetic-guided dose reduction of emicizumab in congenital hemophilia A: interim analysis of the DosEmi study.
Konrad van der Zwet, Amber D W de Vos, Marjon H Cnossen, Floor C J I Heubel-Moenen, Saskia E M Schols

J Thromb Haemost· November 2025

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In Silico Assessment of Limited Blood Sampling Strategies for Individualised Pharmacokinetic-guided Dosing of Efanesoctocog Alfa in Haemophilia A Patients.
Jelien den Hollander, Marjon H Cnossen, Ron A A Mathôt

Haemophilia· November 2025

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Relationship between Dose, Factor IX Activity Levels and Bleeding Probability for rIX-FP Prophylaxis in Hemophilia B: A Repeated Time-to-Event Analysis.
Sjoerd F Koopman, Marjon H Cnossen, Ron A A Mathot,

Clin Pharmacol Ther· October 2025

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Real-world population pharmacokinetics of tezacaftor-ivacaftor in children with cystic fibrosis: The SYM-CF study.
Steffie E M Vonk, Suzanne W J Terheggen-Lagro, Eric G Haarman, Hettie M Janssens, Anke-Hilse Maitland-van der Zee

Br J Clin Pharmacol· October 2025

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A repeated time-to-event model for personalized treatment of patients with hemophilia A based on individual bleeding risk.
Alexander Janssen, Frank C Bennis, Marjon H Cnossen, Ron A A Mathôt

J Thromb Haemost· September 2025

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Real-world pharmacokinetics of elexacaftor-tezacaftor-ivacaftor in children with cystic fibrosis: a prospective observational study.
Steffie E M Vonk, Suzanne W J Terheggen-Lagro, Eric G Haarman, S Hashimoto, Anke H Maitland-van der Zee

J Cyst Fibros· May 2025

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Amikacin dosing in neonates: evaluation of target attainment using a simplified and complex pharmacokinetic model-derived dosing regimen in clinical practice.
Marlotte A A van der Veer, Anne Smits, Timo R de Haan, Linda G W Franken, Anton H van Kaam

Antimicrob Agents Chemother· April 2025

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Rabies in humans: A treatment approach.
Cornelis A De Pijper, Pieter P A M van Thiel, Diederik van de Beek, Matthijs C Brouwer, Eleonora Aronica

Travel Med Infect Dis· March 2025

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Disease-Drug-Drug Interaction of Imatinib in COVID-19 ARDS: A Pooled Population Pharmacokinetic Analysis.
Medhat M Said, Job R Schippers, Leila Atmowihardjo, Yingxue Li, Mick S van der Plas

CPT Pharmacometrics Syst Pharmacol· March 2025

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Replacement therapy in pregnant women with von Willebrand disease during delivery: Factor levels and pharmacokinetics.
Wala Al Arashi, Michael E Cloesmeijer, Frank W G Leebeek, Johannes J Duvekot, Marieke J H A Kruip

Hemasphere· January 2025

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Dried Blood Spot Method Development and Clinical Validation for the Analysis of Elexacaftor, Elexacaftor-M23, Tezacaftor, Tezacaftor-M1, Ivacaftor, Ivacaftor Carboxylate, and Hydroxymethyl Ivacaftor Using LC-MS/MS.
Steffie E M Vonk, Marloes van der Meer-Vos, Renate Kos, Anne H Neerincx, Suzanne W J Terheggen-Lagro

Ther Drug Monit· December 2024

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Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximations.
Alexander Janssen, Frank C Bennis, Marjon H Cnossen, Ron A A Mathôt,

J Pharmacokinet Pharmacodyn· December 2024

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A quantitative method for the analysis of total and unbound concentrations of amoxicillin, ampicillin, ceftazidime, ceftriaxone, ertapenem, fosfomycin and penicillin G in human plasma with liquid chromatography-tandem mass spectrometry assay.
Marlotte A A van der Veer, Marloes van der Meer-Vos, Timo R de Haan, Linda G W Franken, Yuma A Bijleveld

Biomed Chromatogr· October 2024

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PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space.
Michael E Cloesmeijer, Erik Sjögren, Sjoerd F Koopman, Peter J Lenting, Marjon H Cnossen

CPT Pharmacometrics Syst Pharmacol· October 2024

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Correlation between trough concentration and AUC for elexacaftor, tezacaftor and ivacaftor.
Steffie E M Vonk, Josje Altenburg, Ron A A Mathôt, E Marleen Kemper,

J Cyst Fibros· September 2024

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On inductive biases for the robust and interpretable prediction of drug concentrations using deep compartment models.
Alexander Janssen, Frank C Bennis, Marjon H Cnossen, Ron A A Mathôt,

J Pharmacokinet Pharmacodyn· August 2024

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Saliva monitoring of prednisolone in children with first onset steroid-sensitive nephrotic syndrome: Is it possible?
Floor Veltkamp, Marcel C M Pistorius, Elske M Mak-Nienhuis, Michiel F Schreuder, Antonia H M Bouts

Br J Clin Pharmacol· July 2024

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Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data.
Amara Nassar-Sheikh Rashid, Femke Hooijberg, Sandy C Bergkamp, Mariken P Gruppen, Taco W Kuijpers

Paediatr Drugs· July 2024

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Plasma and tissue concentrations of 2 g prophylactic cefazolin prior to lower extremity surgery.
Robin Eelsing, Diederick Penning, Marloes Vos-van der Meer, Caspar J Hodiamont, Ron A A Mathôt

Antimicrob Agents Chemother· July 2024

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Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia.
Marlotte A A van der Veer, Timo R de Haan, Linda G W Franken, Reinier M van Hest, Floris Groenendaal

Br J Clin Pharmacol· June 2024

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A Generative and Causal Pharmacokinetic Model for Factor VIII in Hemophilia A: A Machine Learning Framework for Continuous Model Refinement.
Alexander Janssen, Louk Smalbil, Frank C Bennis, Marjon H Cnossen, Ron A A Mathôt

Clin Pharmacol Ther· April 2024

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Smaller nadroparin dose reductions required for patients with renal impairment: A multicenter cohort study.
Renate C A E van Uden, Tessa C C Jaspers, Karina Meijer, Karlijn J van Stralen, Barbara Maat

Thromb Res· April 2024

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Peri-operative desmopressin combined with pharmacokinetic-guided factor VIII concentrate in non-severe haemophilia A patients.
Lorenzo G R Romano, Lisette M Schütte, Reinier M van Hest, Karina Meijer, Britta A P Laros-van Gorkom

Haemophilia· March 2024

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Pharmacokinetic-Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate.
Lars L F G Valke, Michael E Cloesmeijer, Hassan Mansouritorghabeh, Wideke Barteling, Nicole M A Blijlevens

Eur J Drug Metab Pharmacokinet· March 2024

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Predictive performance of pharmacokinetic-guided prophylactic dosing of factor concentrates in hemophilia A and B.
Tine M H J Goedhart, Laura H Bukkems, Anne-Fleur Zwagemaker, Michiel Coppens, Karin Fijnvandraat

Res Pract Thromb Haemost· March 2024

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