Publications by authors named "Roque Spinelli"

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Fighting Alzheimer's naturally: Peptides as multitarget drug leads.
Roque Spinelli, Ivan Sanchís, Alvaro Siano

Bioorg Med Chem Lett· November 2025

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Cost-effective synthesis of a chromogenic substrate for SARS-CoV-2 M and development of a miniaturized high-throughput inhibition assay.
Roque Spinelli, Maria Veronica Humpola, Ivan Sanchis, Alvaro S Siano

Methods Enzymol· November 2025

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N-methylation of bioactive peptides as a conformational constraint tool to improve enzymatic stability.
Maria Veronica Húmpola, Roque Spinelli, Alvaro S Siano

Methods Enzymol· November 2025

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Amphibian-Derived Peptides as Natural Inhibitors of SARS-CoV-2 Main Protease (M): A Combined In Vitro and In Silico Approach.
Roque Spinelli, Iván Sanchis, Álvaro Rietmann, María Verónica Húmpola, Álvaro Siano

Chem Biodivers· June 2025

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Specific Rosetta-based protein-peptide prediction protocol allows the design of novel cholinesterase inhibitor peptides.
Ivan Sanchis, Florencia Aimaretti, Matias Lupotti, Alvaro Rietmann, José Dias, Roque Spinelli

Bioorg Chem· March 2025

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Toxicity Evaluation of Anti-cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test.
Roque Spinelli, Álvaro Rietmann, Iván Sanchis, Héctor Goicoechea, Álvaro Siano

Chem Biodivers· February 2024

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Acetylcholine hydrolytic activity of fibrillated β-amyloid (1-40) peptide.
Ivan Sanchis, Roque Spinelli, Alvaro Siano

Amino Acids· December 2023

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Inhibition of Human Cholinesterases and in vitro β-Amyloid Aggregation by Rationally Designed Peptides.
Ivan Sanchis, Roque Spinelli, José Dias, Xavier Brazzolotto, Álvaro Rietmann

ChemMedChem· June 2023

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D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides.
Maria Veronica Humpola, Roque Spinelli, Melina Erben, Virginia Perdomo, Georgina Guadalupe Tonarelli

Antibiotics (Basel)· April 2023

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Development of low-cost cage-like particles to formulate veterinary vaccines.
Giuliana A Lupi, Florencia X Santiago Valtierra, Gabriel Cabrera, Roque Spinelli, Álvaro S Siano

Vet Immunol Immunopathol· September 2022

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Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the skin.
Roque Spinelli, Álvaro Rietmann, Ivan Sanchis, Álvaro Sebastián Siano

Nat Prod Res· June 2022

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Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants.
Ivan Sanchis, Roque Spinelli, Nicolas Aschemacher, Alvaro Sebastían Siano

Amino Acids· February 2022

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Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer's disease.
Roque Spinelli, Florencia María Aimaretti, Javier Alejandro López, Alvaro Sebastián Siano

Nat Prod Res· February 2021

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Cytotoxic and antiproliferative activities of amphibian (anuran) skin extracts on human acute monocytic leukemia cells.
Roque Spinelli, Laura Andrea Barrero Guevara, Javier Alejandro López, Carolina Muñoz Camargo, Helena Groot de Restrepo

Toxicon· April 2020

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Acetylcholinesterase inhibitory activity of a naturally occurring peptide isolated from Boana pulchella (Anura: Hylidae) and its analogs.
Ivan Sanchis, Roque Spinelli, Nicolas Aschemacher, Ma Veronica Humpola, Alvaro Siano

Amino Acids· March 2020

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Natural Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidase Enzymes with Antioxidant Potential from Skin Extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae).
Roque Spinelli, Ivan Sanchis, Florencia M Aimaretti, Andres M Attademo, Madelon Portela

Chem Biodivers· January 2019

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