Publications by authors named "Rory B Conolly"

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Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat.
Rory B Conolly, Jeffry Schroeter, Julia S Kimbell, Harvey Clewell, Melvin E Andersen

Toxicol Sci· May 2023

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Case Study in 21st-Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo.
Daniel L Villeneuve, Brett R Blackwell, Chad A Blanksma, Jenna E Cavallin, Wan-Yun Cheng, Rory B Conolly

Environ Toxicol Chem· January 2023

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Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa.
Rory B Conolly, Jerry L Campbell, Harvey J Clewell, Jeffry Schroeter, Julia S Kimbell

Toxicol Sci· January 2023

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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds.
Rongrui Liu, Tim R Zacharewski, Rory B Conolly, Qiang Zhang

Toxics· November 2022

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Development of a Novel AOP for Cyp2F2-Mediated Lung Cancer in Mice.
Thomas Hill, Rory B Conolly

Toxicol Sci· November 2019

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A Quantitative Source-to-Outcome Case Study To Demonstrate the Integration of Human Health and Ecological End Points Using the Aggregate Exposure Pathway and Adverse Outcome Pathway Frameworks.
David E Hines, Rory B Conolly, Annie M Jarabek

Environ Sci Technol· September 2019

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Embracing Systems Toxicology at Single-Cell Resolution.
Qiang Zhang, W Michael Caudle, Jingbo Pi, Sudin Bhattacharya, Melvin E Andersen, Rory B Conolly

Curr Opin Toxicol· August 2019

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An updated analysis of respiratory tract cells at risk for formaldehyde carcinogenesis.
Frederick J Miller, Rory B Conolly, Julia S Kimbell

Inhal Toxicol· January 2019

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High-Throughput Video Processing of Heart Rate Responses in Multiple Wild-type Embryonic Zebrafish per Imaging Field.
W Kyle Martin, Alan H Tennant, Rory B Conolly, Katya Prince, Joey S Stevens

Sci Rep· January 2019

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Bridging the Data Gap From Toxicity Testing to Chemical Safety Assessment Through Computational Modeling.
Qiang Zhang, Jin Li, Alistair Middleton, Sudin Bhattacharya, Rory B Conolly

Front Public Health· September 2018

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Changes in Metabolites Present in Lung-Lining Fluid Following Exposure of Humans to Ozone.
WanYun Cheng, Kelly E Duncan, Andrew J Ghio, Cavin Ward-Caviness, Edward D Karoly, Rory B Conolly

Toxicol Sci· June 2018

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A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA).
David E Hines, Stephen W Edwards, Rory B Conolly, Annie M Jarabek

Environ Sci Technol· January 2018

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Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology.
Rory B Conolly, Gerald T Ankley, WanYun Cheng, Michael L Mayo, David H Miller

Environ Sci Technol· April 2017

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Computational model of the fathead minnow hypothalamic-pituitary-gonadal axis: Incorporating protein synthesis in improving predictability of responses to endocrine active chemicals.
Miyuki Breen, Daniel L Villeneuve, Gerald T Ankley, David Bencic, Michael S Breen, Rory B Conolly

Comp Biochem Physiol C Toxicol Pharmacol· December 2016

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Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses.
Qiang Zhang, Sudin Bhattacharya, Rory B Conolly, Harvey J Clewell, Norbert E Kaminski

Environ Health Perspect· December 2014

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Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages.
Jeffry D Schroeter, Jerry Campbell, Julia S Kimbell, Rory B Conolly, Harvey J Clewell

Toxicol Sci· April 2014

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A framework for fit-for-purpose dose response assessment.
M E Bette Meek, Michael Bolger, James S Bus, John Christopher, Rory B Conolly

Regul Toxicol Pharmacol· July 2013

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Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling.
Miyuki Breen, Daniel L Villeneuve, Gerald T Ankley, David C Bencic, Michael S Breen, Rory B Conolly

Toxicol Sci· June 2013

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Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I. Data generation in a small fish model.
Daniel L Villeneuve, Miyuki Breen, David C Bencic, Jenna E Cavallin, Kathleen M Jensen, Rory B Conolly

Toxicol Sci· June 2013

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All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Qiang Zhang, Douglas E Kline, Sudin Bhattacharya, Robert B Crawford, Rory B Conolly

Toxicol Appl Pharmacol· April 2013

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Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage.
Yuchao Zhao, In Chio Lou, Rory B Conolly

Dose Response· October 2012

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An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".
Thomas Hartung, Bas J Blaauboer, Sieto Bosgra, Edward Carney, Joachim Coenen, Rory B Conolly

ALTEX· February 2012

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The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis.
Frederick J Miller, Julia S Kimbell, R Julian Preston, John H Overton, Elizabeth A Gross, Rory B Conolly

Inhal Toxicol· October 2011

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Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical--metyrapone.
Miyuki Breen, Michael S Breen, Natsuko Terasaki, Makoto Yamazaki, Alun L Lloyd, Rory B Conolly

Toxicol Sci· September 2011

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A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens.
Susan P Felter, Rory B Conolly, Joel P Bercu, P Michael Bolger, Alan R Boobis

Crit Rev Toxicol· July 2011

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